Clinical trials: Periapical Healing
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Endodontic Disease, Endodontically Treated Teeth
Outcome of Endodontic Retreatment in One or Two Visits
This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease.
- Conditions
- Endodontic Disease, Endodontically Treated Teeth, Root Canal Infection
- Trial name
- NCT04527705
- Testing
- Non-surgical root canal retreatment
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Universitat Internacional de Catalunya
Retreatment, Asymptomatic Apical Periodontitis
Effects of Irrigation Activation Systems on Postoperative Pain and Lesion Healing in Single-Visit Retreatment
In this superiority randomized clinical trial with a parallel design, 75 asymptomatic maxillary anterior teeth with 2-5 mm periapical lesions and a history of primary root canal treatment (PRCT) at least four years earlier were…
- Trial name
- NCT07150585
- Testing
- Ultrasonic Activation Group, Sonic Activation Group, Laser Activation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ege University
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periapical Diseases
Efficiency of Diode Laser Activated Irrigation on Healing of Periapical Tissues
Study is a Randomized clinical trial conducted at Endodontic department- Ain Shams university Cairo. Egypt. 24 eligible patients were selected and included in the study to compare healing ability of diode laser activated…
- Trial name
- NCT04311905
- Testing
- Diode laser
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periapical Healing
Evaluation of Three Different Intra-canal Medicaments
Periapical lesions are the commonly occurring pathologic lesions that affect the periradicular tissues of the tooth . This lesion can be classified as granuloma, cystic, or abscess .The pathologic changes seen in some…
- Trial name
- NCT07892703
- Testing
- Metapaste Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Minia University
Periapical Lesions
Guided Tissue Regeneration in the Healing of Through and Through Lesions
Study Title: Effects of Guided Tissue Regeneration on the Healing of Through \& Through Periradicular Lesions - A Randomized Controlled Study Rationale: Through and through defects found to be difficult to heal without GTR…
- Trial name
- NCT03284736
- Testing
- Resorbable membrane, periapical surgery without membrane
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Lesion, Apical Periodontitis
Effect of Apical Patency on Periapical Lesion Healing
This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth.
- Conditions
- Periapical Lesion, Apical Periodontitis, Dental Pulp Necroses, Mouth Diseases
- Trial name
- NCT07867314
- Testing
- Apical Patency During Root Canal Treatment, Root Canal Treatment Without Apical Patency
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people
- Sponsor
- Recep Tayyip Erdogan University
Immature Teeth, Periapical Lesion
Three Techniques in Bioceramic Apexification for Necrotic Immature Incisors
The goal of this randomized clinical trial is to find the most effective Bioceramic-based apexification procedures in children with immature necrotic maxillary incisors.
- Trial name
- NCT06119477
- Testing
- Bioceramic Putty Apical Plugs, Single Cone Gutta-percha with Bioceramic Sealer, Combination of Bioceramic Putty and Sealer
- Where
- Syria
- Volunteers
- 45 people
- Sponsor
- Damascus University
Endodontic Inflammation
Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment
The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth.
- Trial name
- NCT07779148
- Testing
- Xp Finisher R file
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Minia University
Persistent Infection, Periapical Lesion
The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants in Endodontic Retreament in RCT
Endodontic treatment aims to eliminate pathogenic microbes from the root canal. Hyperpure chlorine dioxide is an endodontic irrigant.
- Trial name
- NCT04954638
- Testing
- endodontic desinfection
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Eniko Vaszine Szabo
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Periapical Diseases, Bioceramic Sealers
Survival and Success of Two Different Filling Techniques
This randomized clinical study analysed the clinical use of a new bioceramic premixed CaSi-containing sealer in association with a warm carrier-based technique or a traditional epoxy resin based sealer.
- Conditions
- Periapical Diseases, Bioceramic Sealers, Survival Rate, Healing Rate
- Trial name
- ROOTCANAL (NCT06252337)
- Testing
- bioceramic sealer group
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Periapical Lesion
A Comparative Analysis of Biomaterials for Retrograde Filling in Apical Surgery.
The aim of this study is to compare two biomaterials used for retrograde obturation during apical surgery. This surgery is indicated in healthy patients when root canal treatment (endodontics) has failed to eliminate a periapical…
- Trial name
- NCT07246512
- Testing
- Mineral Trioxide Aggregate, BioCeramic Root Repair Material Fast Set Putty.
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Valencia
Root Canal Obturation, Apical Periodontitis
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers
The root canal treatment of volunteers with asymptomatic apical periodontitis will be completed using TotalFill BC and AH Plus root canal sealers, and postoperative pain as well as healing will be comparatively evaluated through…
- Trial name
- NCT07307807
- Testing
- AH Plus and PAI 2-3, AH Plus and PAI 4, TotalFill BC Sealer and PAI 2-3
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ankara Yildirim Beyazıt University
Periapical Disease
Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing
The goal of this clinical trial is to compare the effects of different intracanal medication between endodontic retreatment visits in previously failed root canal treatment patients (single root canal anteriors or premolars…
- Trial name
- NCT06342830
- Testing
- nanocurcumin gel, Curcumin Gel, Ciprofloxacin 500 mg +ibuprofen 400mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periapical Diseases, Endodontic Disease
Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication
The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided…
- Trial name
- NCT06643663
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Asymptomatic Irreversible Pulpitis
Effect of Apical Third Enlargement to Different Taper and Master Apical Preparation Size on Periapical Healing and Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment
To Determine Effect Of Apical Third enlargement To Different Taper And Master Apical Preparation Size On Periapical Healing And Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment : A Randomized…
- Trial name
- NCT07166679
- Testing
- root canal treatment with 2% taper, root canal treatment with 4% taper, root canal treatment with 6 %taper
- Where
- India
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Periodontitis, Irrigation Activation
Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions
The primary goal of endodontic treatment is to treat the infection by optimally cleaning the root canal system and precentig reinfection.
- Conditions
- Periapical Periodontitis, Irrigation Activation, Lasers
- Trial name
- NCT06991803
- Testing
- root canal treatment and irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Recep Tayyip Erdogan University
Apical Periodontitis
Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement
The goal of this clinical trial is to conduct an in vivo study that allows to compare the periapical healing process of 3 different sealing cements through CBCT, as well as implement the evaluation of these lesions through…
- Trial name
- NCT06482593
- Testing
- Zinc-Oxide Eugenol Sealer, AH-Plus Epoxy Resin Sealer, Bio-C Sealer
- Where
- Colombia
- Volunteers
- 72 people
- Sponsor
- Institucion Universitaria Colegios de Colombia