Clinical trials: Percutaneous Coronary Intervention (PCI)
Coronary Artery Disease
CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 4
This study is multi-center, open label, two-by-two factorial, randomized, noninferiority trial to compare the efficacy and safety of polymer-free cobalt-chromium thin drug-coated stents (BioFreedom Ultra) with biodegradable…
- Trial name
- SMART-CHOICE4 (NCT05066789)
- Testing
- Type of stent, Duration of DAPT
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Primary Percutaneous Coronary Intervention
Influence Of Incomplete Revascularization on Long-Term Outcomes After Primary Percutaneous Coronary Intervention (PPCI)
evaluate the influence of incomplete revascularization during the index hospitalization on in-hospital and long-term outcomes in STEMI patients undergoing PPCI in Assiut University heart hospital.
- Trial name
- NCT04332250
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Amany Edward Ramzy
Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction…
- Trial name
- PCAB-AMI (NCT07467213)
- Testing
- Zastaprazan, Proton Pump Inhibitors (PPI)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndrome, Myocardial Infarction
Point of Care (POC) Biomarkers of Ischemia
Acute coronary syndrome is defined as myocardial infarction or ischemia as evidenced by significant coronary artery disease on cardiac catheterization/revascularization or reversible defect seen on stress test.
- Trial name
- NCT02039882
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Acute Anterior Myocardial Infarction
Effects of Intensive Statin Treatment on Left Ventricular Function
First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left…
- Trial name
- NCT01936103
- Testing
- standard group, intensive group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenyang Northern Hospital
Angioplasty, Transluminal, Percutaneous Coronary
A Study Comparing the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Combination With Two Different Heparin Regimens in Patients Undergoing Percutaneous Coronary Intervention.
The purpose of this study is to compare the safety and effectiveness of abciximab, an anti-platelet therapy, versus placebo in patients undergoing percutaneous coronary intervention when administered in combination with two…
- Trial name
- NCT00269880
- Testing
- Heparin, Abciximab
- Volunteers
- 2,792 people
- Sponsor
- Centocor, Inc.
Coronary Heart Disease
China PEACE-Retrospective CathPCI Study
Coronary heart disease (CHD) is one of the leading causes of mortality and morbidity. PCI, as a well-proved and booming measure in CHD management, is invasive and of high cost, however the knowledge about the real-life PCI use in…
- Trial name
- NCT01624896
- Volunteers
- 12,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Type 2 Diabetes Mellitus
Comparison Between Pioglitazone and SES With type2 DM
Drug-eluting stents have been shown to decrease restenosis, but were associated with an increased rate of death, as compared with bare-metal stents.
- Trial name
- NCT00482183
- Testing
- Pioglitazone
- Volunteers
- 38 people
- Sponsor
- Showa University
Thrombosis
CASTLE (Clopidogrel And Serum Troponin Level Elevation)
Primary Objective: To test if 600 mg of clopidogrel loading dose administered ≥ 6 and ≤ 24 hours prior to PCI produce a greater decrease of periprocedural release of biochemical markers (CK, CK-MB, and troponin-T and/or I) of…
- Trial name
- CASTLE (NCT00716924)
- Testing
- Clopidogrel
- Where
- Mexico
- Volunteers
- 155 people
- Sponsor
- Sanofi
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Physical Activity
Physical Activity Telehealth Intervention After Percutaneous Coronary Procedures
The purpose of this study is to test the feasibility of using targeted daily cell phone interaction to facilitate behavior change for physical activity in previously-sedentary individuals who have recently undergone a…
- Trial name
- NCT01673100
- Testing
- Physical Activity Promotion Intervention
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
Coronary Artery Disease
Patient-reported Outcomes After Percutaneous Coronary Intervention
The main objective is to investigate i) continuity of care, ii) health literacy and self-management, iii) adherence to treatment, and iv) patient preferences, healthcare utilization and costs, and to determine associations with…
- Trial name
- CONCARD (NCT03810612)
- Where
- 7 sites in Denmark, Norway
- Volunteers
- 3,417 people
- Sponsor
- Haukeland University Hospital
Clopidogrel Non-Responsiveness
Clopidogrel Reloading in Clopidogrel Resistant Patients With ACS
Laboratory clopidogrel resistance is associated with adverse atherothrombotic events in patients with coronary artery disease. In the proposed study we wish to prospectively assess the effect of reloading with 600 mg clopidogrel…
- Trial name
- NCT00444132
- Testing
- clopidogrel
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Chronic Total Occlusion
Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery
Coronary arteries are in charge of oxygen supply for the myocardium. When coronary arteries develop stenosis the coronary blood flow (i.e. oxygen flow) is reduced.
- Trial name
- DAPT-CTO (NCT06175377)
- Testing
- Percutaneous coronary intervention, Short dual Aspirin/Clopidogrel therapy, Long dual Aspirin/Clopidogrel therapy
- Volunteers
- 660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Contrast-induced Acute Kidney Injury, ST Elevation Myocardial Infarction
A Randomized Trial of Rosuvastatin Loading Combined With Early hydrAtion Versus Standard-of-care Medications for the Prevention of CIAKI in Patient With AMI Undergoing Emergency PCI
The CIAKI,as the third complication of PCI, was associated with adverse cardiac events after procedure. Moreover, because the rate of periprocedure hydration is inadequate in STEMI patients before primary PCI, the incidence of…
- Conditions
- Contrast-induced Acute Kidney Injury, ST Elevation Myocardial Infarction, Primary PCI, Rosuvastatin
- Trial name
- TRACK-AMI (NCT03526367)
- Testing
- hydration plus rosuvastatin therapy, Standard therapy
- Where
- China
- Sponsor
- Shenyang Northern Hospital
Coronary Artery Disease
Comparing Bivalirudin Versus Heparin/ GP IIB/IIA in Patients Undergoing PCI
The purpose of this study is to compare the rates of vascular related complications in patients undergoing percutaneous coronary intervention assigned to one of two arms: 1) bivalirudin + provisional Gp IIB/IIIA use versus 2)…
- Trial name
- NCT00476944
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- United States
- Sponsor
- Gold, Herman K., MD
Coronary Disease, Percutaneous Coronary Intervention
Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women
A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).
- Conditions
- Coronary Disease, Percutaneous Coronary Intervention, Exercise Test, Myocardial Perfusion Imaging
- Trial name
- FiRST (NCT04599192)
- Testing
- No study intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Yale University
Myocardial Infarction
Timing of Complete Revascularization for Multivessel Coronary Artery Disease in STEMI
The study will compare clinical outcomes between complete revascularization during hospitalization for ST elevation myocardial infarction (STEMI) and intervention after 30 days and intervention based on outpatient non-invasive…
- Trial name
- MVD (NCT02756000)
- Testing
- PCI, dobutamine stress echocardiography
- Where
- 4 sites in Serbia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Center Zemun
Acute Myocardial Infarction
Ischemic Time and Extent of Myocardial Infarction (MI) With Cardiac Magnetic Resonance Imaging (CMRI) in Patients With ST Elevation Myocardial Infarction (STEMI) and Primary Percutaneous Coronary Intervention (PCI) Study
This study will assess relationship between ischemic time and the extent of myocardial infarction with cardiac magnetic resonance image in patients with STEMI (ST elevation myocardial infarction) and primary percutaneous coronary…
- Trial name
- ITEMMRI (NCT01401881)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medstar Health Research Institute
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