Clinical trials: Penile Squamous Cell Carcinoma (PSCC), open to volunteers
Penile Squamous Cell Carcinoma (PSCC)
DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma
The DEPECA-1 trial is the first systematic Phase II trial to evaluate response and survival to a combination of antibody-drug conjugate enfortumab vedotin plus the PD-L1 inhibitor avelumab in patients with locally advanced and…
- Trial name
- NCT07110038
- Testing
- Avelumab, enfortumab vedotin
- Where
- 9 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Penile Squamous Cell Carcinoma (PSCC), Advanced Penile Cancer
Sacituzumab Tirumotecan Plus Toripalimab for Advanced Penile Cancer After Platinum Chemotherapy
This is a single-center, single-arm, open-label, Phase 2 clinical trial (the SCOPE study) evaluating the efficacy, safety, and tolerability of sacituzumab tirumotecan (SKB264) combined with toripalimab as a second-line…
- Conditions
- Penile Squamous Cell Carcinoma (PSCC), Advanced Penile Cancer, Metastatic Penile Cancer, Locally Advanced Penile Cancer
- Trial name
- SCOPE (NCT07907861)
- Testing
- Sacituzumab Tirumotecan (SKB264), Toripalimab
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Anhui Provincial Hospital
Penile Cancer, Penile Squamous Cell Carcinoma (PSCC)
Neoadjuvant Pucotenlimab and Becotatug Vedotin for Locally Advanced Penile Cancer
This is an open-label, multicenter, single-arm Phase 2 clinical trial evaluating neoadjuvant pucotenlimab (anti-PD-1 immunotherapy) combined with becotatug vedotin (EGFR-targeted antibody-drug conjugate, ADC) for adults with…
- Trial name
- NCT07767266
- Testing
- Pucotenlimab plus Becotatug Vedotin
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Sun Yat-sen University