Clinical trials: Pemphigus
Pemphigus
Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus
The purpose of this research is to study alternative treatments for the skin disease pemphigus (a rare autoimmune blistering disorder of the skin) by using sirolimus, an immunosuppressive drug.
- Trial name
- NCT01313923
- Testing
- Sirolimus (formerly known as Rapamycin)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, Irvine
Pemphigus Disease, Pemphigus Vulgaris (PV)
A Randomized Study on Pemphigus Treatment With Humanized CD38 Antibody CM313.
Pemphigus is characterized by the presence of IgG antibodies that lead to the loss of keratinocyte adhesion, resulting in blister formation.
- Trial name
- NCT06663943
- Testing
- CM313 (SC), Glucocorticoids
- Volunteers
- 100 people
- Sponsor
- Chao Ji
Pemphigus Vulgaris, Rituximab (RTx)
Rituximab With Corticosteroids Versus Corticosteroids Plus Azathioprine for Moderate-to-Severe Pemphigus Vulgaris
This quasi-experimental study aims to compare the effectiveness and safety of rituximab combined with corticosteroids versus the standard regimen of oral corticosteroids plus azathioprine in patients with moderate to severe…
- Trial name
- NCT07769333
- Testing
- Rituxan (rituximab), Azathioprine (AZA)' plus corticosteroids
- Volunteers
- 92 people
- Sponsor
- Khyber Teaching Hospital
Pemphigus
Validation of 5-Point Investigator Global Assessments for Pemphigus
This study aims to explore the reliability and validity of newly developed Investigator Global Assessments (IGAs) in scoring the severity of pemphigus.
- Trial name
- NCT05534776
- Testing
- Investigator Global Assessments (IGAs)
- Where
- 7 sites in Australia, Bulgaria and 5 more
- Volunteers
- 40 people
- Sponsor
- Premier Specialists, Australia
Pemphigus, Pemphigus Vulgaris (PV)
Efficacy and Safety Evaluation of Anti-CD20 Monoclonal Antibody Combined with Azathioprine and Corticosteroids in the Treatment of Pemphigus Vulgaris
A prospective cohort study was conducted, following patients for 36 weeks from January 1, 2023, to April 30, 2024. Patients meeting the diagnostic criteria were nonrandomly grouped based on screening results.
- Trial name
- NCT06654817
- Testing
- Ofatumumab subcutaneous injection
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Chao Ji
Pemphigus Vulgaris, Skin Erosion
Effect of Topical Insulin on Healing Rate of Pemphigus Lesions
This study investigates the efficacy of topical insulin in promoting healing of pemphigus vulgaris erosions. Twenty patients with pemphigus vulgaris were enrolled, each contributing three comparable lesions randomly allocated to…
- Conditions
- Pemphigus Vulgaris, Skin Erosion, Autoimmune Blistering Disease
- Trial name
- NCT07461103
- Testing
- insulin glargine, human insulin, 0.9% Normal Saline
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Pemphigus Vulgaris
Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris
The purpose of the study is to find out about the effectiveness and the safety of an investigational drug called etanercept (Enbrel) to treat pemphigus vulgaris.
- Trial name
- NCT00135720
- Testing
- Enbrel (Etanercept)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Pemphigus Vulgaris
Role of Tzanck Smear in Determining Pemphigus Vulgaris Disease Activity
Aim: Pemphigus vulgaris (PV) is a rare, life-threatening autoimmune bullous disease that can involve the skin and mucous membranes, characterized by intraepidermal bullae and eroded lesions caused by rupture of the bullae.
- Trial name
- NCT05338112
- Testing
- Tzanck smear
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medeniyet University
Pemphigus Vulgaris
Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris
The study evaluated the efficacy, safety and pharmacokinetics of VAY736 in the treatment of patients with pemphigus vulagaris (PV).
- Trial name
- NCT01930175
- Testing
- VAY736
- Where
- 5 sites in United States, Austria and 2 more
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Pemphigus Vulgaris (PV)
Trichoscopy as a Monitoring Tool for Activity and Remission in Pemphigus Vulgaris: A Clinical Study Supported by Immunological Evaluation.
Pemphigus vulgaris (PV) is a potential life-threatening autoimmune bullous disorder presenting with multiple erosions and flaccid blisters that can involve both mucous membrane and skin.
- Trial name
- NCT06863454
- Testing
- Trichoscopy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pemphigus, Pemphigoid
Wound Dressings for Pemphigus and Pemphigoid
The purpose of this study is to compare the efficacy of four dressings (covers) namely: gauze with petrolatum , cellulose acetate with petrolatum , pure carboxymethylcellulose with silver and nanocrystalline silver to improve the…
- Trial name
- NCT02365675
- Testing
- Cotton gauze with petrolatum, Cellulose acetate with petrolatum, Nanocrystalline silver (Acticoat)
- Where
- 2 sites in Mexico
- Volunteers
- 12 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Hailey Hailey Disease
Efficacy of Guselkumab in Treating Hailey Hailey Disease
Hailey-Hailey disease (HHD) is a debilitating genetic skin disorder, affecting mainly body folds with erythema and painful erosions and blisters.
- Trial name
- NCT06651489
- Testing
- Guselkumab
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Pemphigus Disease, Rituximab (RTx)
A Single Cycle of Intravenous Immunoglobulin as Adjuvant to Rituximab in Patients With Pemphigus: A Retrospective Cohort Study at a Tertiary Referral Center
Pemphigus is a critical autoimmune skin condition mediated by pathogenic autoantibodies mainly against desmoglein (Dsg)1 and Dsg3, and is traditionally managed with systemic corticosteroids and immunosuppressants.The…
- Conditions
- Pemphigus Disease, Rituximab (RTx), Intravenous Immunoglobulin
- Trial name
- NCT06949241
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Ruijin Hospital
Pemphigus Vulgaris
A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
Open-label cohort study in adult patients with newly diagnosed or relapsing pemphigus vulgaris, with intra-patient dose-adjustment based on clinical response and BTK occupancy, and with conventional immunosuppressive "rescue…
- Trial name
- NCT02704429
- Testing
- PRN1008
- Where
- 13 sites in Australia, Croatia and 3 more
- Volunteers
- 42 people
- Sponsor
- Principia Biopharma, a Sanofi Company
Pemphigus, Dermatologic Disease
Comparison of a Personalized Maintenance Therapy With the Standard Treatment in Pemphigus
Pemphigus diseases are life-threatening chronic autoimmune blistering diseases characterized by split formation within the epidermis and surface-close epithelia accompanied by acantholysis.
- Trial name
- RITUX4 (NCT05898308)
- Testing
- RiTUXimab Injection
- Where
- 34 sites in France, Guadeloupe
- Volunteers
- 133 people
- Sponsor
- University Hospital, Rouen
Pemphigus Disease, Rituximab (RTx)
Efficacy and Safety of Different Doses of Rituximab Therapy in Pemphigus Patients
Investigating the clinical efficacy of different doses of rituximab in patients with pemphigus
- Trial name
- NCT07457944
- Where
- China
- Volunteers
- 275 people
- Sponsor
- Ruijin Hospital
Hailey-Hailey Disease
Skin Microbiome Profile in Hailey-Hailey Disease
"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion.
- Trial name
- NCT05007223
- Testing
- Doxycycline
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Pemphigus Vulgaris, Bullous Pemphigoid
Ozonated Olive Oil in Treatment of Pemphigus Vulgaris and Bullous Pemphigoid
This study assesses the disinfectant and healing promoting effect of ozonated olive oil in treatment of pemphigus vulgaris and bullous pemphigoid in comparison to conventional topical treatment with topical antibiotic.
- Trial name
- NCT05594472
- Testing
- Ozonated olive oil, Topical garamycin cream
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Pemphigus
Long-term Clinical and Biological Evaluation of Patients With Severe Forms of Pemphigus Treated by Rituximab
The purpose of this study is to study the midterm clinical evaluation, biological parameters and immune reconstitution after Rituximab treatment for Pemphigus.
- Trial name
- Suiviritux (NCT01299857)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Rouen
Pemphigoid, Bullous, Pemphigus
Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid
The primary objective of this study is to describe and compare plasmatic anti-proteasome auto-antibody concentrations among three distinct groups: (1) patients suffering from bullous pemphigoide; (2) patients suffering from other…
- Conditions
- Pemphigoid, Bullous, Pemphigus, Lupus Erythematosus, Cutaneous
- Trial name
- NCT01559155
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes