Clinical trials: Pelvic Floor Prolapse
Pelvic Organ Prolapse (POP), Cystocele
Poly-L-Lactic Acid for Vulvovaginal Tissue Regeneration
Pelvic organ prolapse (POP) is a condition characterized by descent of vaginal walls, uterus and cervix, or the perineum and causes a sensation of vaginal bulge and pelvic pressure.
- Conditions
- Pelvic Organ Prolapse (POP), Cystocele, Pelvic Floor Disorder
- Trial name
- NCT07544667
- Testing
- Poly-L-Lactic Acid (Sculptra) injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cassandra Kisby
Pelvic Organ Prolapse
ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study
The primary objective of this study is to assess the safety and effectiveness of MatriStem Pelvic Floor Matrix as compared to native tissue repair for the treatment of pelvic organ prolapse.
- Trial name
- NCT02021279
- Testing
- MatriStem Pelvic Floor Matrix, native tissue repair
- Where
- 13 sites in United States
- Volunteers
- 161 people
- Sponsor
- Integra LifeSciences Corporation
Pelvic Organ Prolapse, Stage II-III
Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse
The purpose of this study is to evaluate the safety and effectiveness of the GYNECARE PROSIMA* Pelvic Floor Repair System as a Device in Women with Symptomatic Pelvic Organ Prolapse.
- Trial name
- NCT01396122
- Testing
- Procedure: GYNECARE PROSIMA* Pelvic Floor Repair System
- Where
- 25 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Floor Disorders
Pelvic Floor Function Evaluation of Singleton Primiparae After Vaginal Delivery and Cesarean Section
Objective of this longitudinal observational cohort study was to analyze incidence of pelvic floor dysfunction (PFD) symptoms, including pelvic organ prolapse (POP), urinary incontinence (UI), and fecal incontinence (FI), seven…
- Trial name
- NCT02661867
- Testing
- delivery
- Volunteers
- 865 people
- Sponsor
- Brno University Hospital
Pelvic Organ Prolapse
Smartmesh Technology in Pelvic Floor Repair Procedures
Pelvic organ prolapse repair involves conservative treatments and surgical treatments. Conservative treatments are for patients with moderate prolapse. Treatment of symptomatic prolapse remains essentially surgical.
- Trial name
- Restorelle (NCT03098641)
- Testing
- pelvic organ prolapse repair
- Where
- 16 sites in France
- Volunteers
- 272 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Pelvic Organ Prolapse
Prolapse and Pregnancy Assessment
Pelvic organ prolapse (POP) is one of the most common indications for gynaecological surgery. In 1997, more than 225000 inpatient surgical procedures for POP were undertaken in USA (22.7 per 10000 women) at an estimated cost of…
- Trial name
- PAPA (NCT01321762)
- Where
- United Kingdom
- Volunteers
- 403 people
- Sponsor
- Croydon University Hospital
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse
Efficacy of Platelet Rich Plasma on Pelvic Floor Muscle Strength and Recurrence Rate in Pelvic Organ Prolapse Surgery
Pelvic organ prolapse (POP) is a common pelvic floor disorder associated with impaired quality of life and considerable postoperative recurrence following native tissue repair.
- Conditions
- Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse, Platelet Rich Plasma Injection
- Trial name
- NCT07746739
- Testing
- POP surgery adjunctive PRP
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Andalas University
Pelvic Organ Prolapse
The Efficacy of Transcutaneous Electrical Nerve Stimulation on LUTS: One Prospective Study.
The study is a prospective study at a single institution. Investigators create strict inclusion and exclusion criteria, selecting 126 patients who undergo the pelvic reconstructive surgery.
- Trial name
- NCT03634722
- Testing
- PHENIX4-8-8 PLUS
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking University People's Hospital
Rectocele, Pelvic Organ Prolapse
Fat Injection for Rectocele Treatment: A Novel Approach
This clinical trial aims to evaluate the effectiveness of autologous fat grafting as a novel treatment for rectocele, a condition characterized by the herniation of rectal tissue into the posterior vaginal wall.
- Conditions
- Rectocele, Pelvic Organ Prolapse, Obstructive Defecation Syndrome
- Trial name
- NCT06604702
- Testing
- Autologous Fat Injection for Rectocele
- Volunteers
- 25 people
- Sponsor
- Cairo University
Pelvic Organ Prolapse (POP), Genital Prolapse
Safety and Performance of a Pelvic Floor Mesh Implant (LatGYNious)
The purpose of the clinical investigation is to verify that the investigational device (LatGYNious) is appropriate to significantly improve the pelvic organ prolapse in patients.
- Conditions
- Pelvic Organ Prolapse (POP), Genital Prolapse, Uterus Prolapse, Laparoscopic Surgery
- Trial name
- NCT07066761
- Testing
- Laparoscopic lateral suspension with surgical mesh (LatGYNious)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 85 people
- Sponsor
- A.M.I. Agency for Medical Innovations GmbH
Pelvic Floor Prolapse
The Effect of Intra-vaginal Conjugated Estrogen Cream on Ring Pessary Use for Pelvic Organ Prolapse
The primary purpose of this two-arm randomized clinical trial is to determine if in women desiring use of a pessary for pelvic organ prolapse (POP) and are successfully fit, if 1-year use and patient impression of improvement is…
- Trial name
- NCT04393194
- Testing
- Vaginal Cream with Applicator [Dose Form]
- Volunteers
- 420 people
- Sponsor
- Peking Union Medical College Hospital
Pelvic Organ Prolapse
GYNECARE PROSIMA* Pelvic Floor Repair System for Pelvic Organ Prolapse
The purpose of this study is to is to evaluate the success of the GYNECARE PROSIMA* system in women with symptoms for pelvic organ prolapse (POP) requiring surgical correction of POP. (*TRADEMARK)
- Trial name
- NCT00521066
- Testing
- GYNECARE PROSIMA* Pelvic Floor Repair System
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 150 people
- Sponsor
- Ethicon, Inc.
Pelvic Floor Dysfunction, Postpartum Care
Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction
The main goal of this study to compare self-training postpartum and training with a specialist support (physiotherapist and physical medicine and rehabilitation doctor) effect on pelvic floor dysfunction prevention and treatment…
- Conditions
- Pelvic Floor Dysfunction, Postpartum Care, Postpartum Comfort, Female Urinary Incontinence and Pelvic Organ Prolapse
- Trial name
- DDDPREV (NCT07426770)
- Testing
- Rehabilitation postpartum, Self-training
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Pelvic Organ Prolapse
Multi-centre Randomised Controlled Trial of Pelvic Floor Muscle Training for Prolapse
The aim of this study is to determine the effectiveness and cost-effectiveness of pelvic floor muscle training in the management of pelvic organ prolapse in women.
- Trial name
- POPPY (NCT00476892)
- Testing
- Pelvic Floor Muscle Training
- Where
- 28 sites in Australia, Ireland and 2 more
- Volunteers
- 448 people
- Sponsor
- Glasgow Caledonian University
Urinary Incontinence,Stress, Stress Urinary Incontinence
Synchronized Core-Pelvic Floor Activation in Urinary Incontinence
This study aims to investigate whether co-activation of the pelvic floor and core muscles improves treatment outcomes in individuals with urinary incontinence.
- Conditions
- Urinary Incontinence,Stress, Stress Urinary Incontinence, Mixed Incontinence Due to Prolapse of Female Genital Organ, Urinary Incontinence
- Trial name
- NCT07387640
- Testing
- Conventional Pelvic Floor Muscle Training, Pelvic Floor and Core Muscle Co-activation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Uterine Prolapse, Stage III
GYNECARE PROSIMA* Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Uterine Prolapse Stage III
Pelvic Organ prolapse (a feeling of bulge in the vagina) may cause some distressing symptoms such as loss of control of the bowel or bladder, and may also cause problems with patient's sex life.
- Trial name
- NCT01396109
- Testing
- Procedure: TVH and GYNECARE PROSIMA* Pelvic Floor Repair System, Procedure: TVH and Modified Pelvic Floor Reconstruction Surgery with mesh
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Quality of Life, Urinary Incontinence
The Pelvic Floor Function and Sexual Life of the Women After Different Type of Hysterectomy
In this prospective, comparative non-randomized multiple teaching hospitals study, the investigators try to determine the relationship of total hysterectomy and Taiwanese female pelvic floor and sexual function from the view of…
- Conditions
- Quality of Life, Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- HYS-PF-QOL (NCT02841059)
- Testing
- LSH, CLSH, LAVH
- Where
- 4 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Pelvic Organ Prolapse
Vaginal Tactile Imaging in Assessment of Pelvic Floor Conditions
The clinical study includes investigation of the outcomes of surgery for biomechanical restoration of pelvic floor conditions, monitoring pelvic floor conditions under conservative treatment/management, identification and…
- Trial name
- NCT02294383
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Artann Laboratories
Pelvic Organ Prolapse, Urinary Incontinence
Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures
This is a randomized controlled trial to determine if there is a difference between chlorhexidine gluconate and povidone iodine vaginal preparations for urogynecological surgery post operative infections.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pelvic Floor Disorders, Gynecologic Disease
- Trial name
- CLNUP (NCT04048356)
- Testing
- Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pelvic Organ Prolapse
Pelvic Floor Support After Laparoscopic Hysterectomy for Benign Conditions: A Randomized Controlled Trial Comparing Vaginal Cuff Closure Techniques
The purpose of this study is to learn about the effect of different vaginal cuff closure techniques on pelvic support after laparoscopic hysterectomy and robotic assisted laparoscopic hysterectomy for benign gynecologic…
- Trial name
- NCT03753516
- Testing
- Laparoscopic - Vaginal Cuff Closure, Vaginal- Vaginal Cuff Closure
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Walter Reed National Military Medical Center