Clinical trials: Pelvic Cancer
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Cancer
Cone Beam Computed Tomography (CT) (CBCT) With and Without a Customized Vacuum Immobilization Device (CVID)
This study is designed to investigate whether or not the use of a customized vacuum immobilization device (CVID) to immobilize rectal cancer patients undergoing preoperative pelvic radiation therapy improves the positional…
- Trial name
- NCT00937248
- Testing
- prone pillow and simple ankle fixation device, Customized Vacuum Immobilization Device (CVID)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Cervical Cancer, Endometrial Cancer
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management
This study compared the efficacy and safety of superior hypogastric plexus block and ganglion impar block procedures on the management of pelvic and perineal cancer pain in patients with cervical and endometrial cancer
- Trial name
- NCT05427058
- Testing
- Superior Hypogastric Plexus Block, Ganglion Impar Block
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- University of Brawijaya
Carcinoma, Transitional Cell, Urinary Bladder Neoplasms
A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer
This is a study that will test how an experimental drug (enfortumab vedotin) affects patients with cancer of the urinary system (urothelial cancer).
- Conditions
- Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Urologic Neoplasms, Renal Pelvis Neoplasms
- Trial name
- EV-201 (NCT03219333)
- Testing
- Enfortumab vedotin
- Where
- 81 sites in United States, France and 6 more
- Volunteers
- 219 people
- Sponsor
- Astellas Pharma Inc
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Radiotherapy Side Effect, Pelvic Cancer
AI as an Aid for Weekly Symptom Intake in Radiotherapy
The study investigates the use of artificial intelligence (AI) and large language models (LLMs) to enhance the efficiency and accuracy of weekly treatment consultations (OTVs) in radiotherapy.
- Conditions
- Radiotherapy Side Effect, Pelvic Cancer, Patient
- Trial name
- NCT06525181
- Testing
- Generative Artificial Intelligence, Standard weekly symptom intake
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- jaide
Adenocarcinoma of the Prostate
Stereotactic Boost and Long-Term Androgen Deprivation for Adenocarcinoma of the Prostate
We hypothesize that Stereotactic Body Radiotherapy Boost (SBRT) as a boost to the prostate following whole pelvic intensity modulated radiotherapy (IMRT) can be delivered effectively and safely in a population of men with…
- Trial name
- CCRO025 (NCT02064036)
- Testing
- Stereotactic Radiosurgical Boost, Casodex, Leuprolide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Davis
Prostate Cancer
Radiation Therapy After Prostatectomy in Treating Patients With Stage III Prostate Cancer
Randomized phase III trial to compare treatment with or without adjuvant radiation therapy in men with stage III prostate cancer who have had radical prostatectomy and lymphadenectomy recently.
- Trial name
- NCT00394511
- Testing
- low-LET photon therapy
- Volunteers
- 408 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma
Radiation Therapy and Chemotherapy in Treating Patients With Locally Advanced Cervical Cancer
This phase I trial is studying the side effects and best way to give radiation therapy when given together with topotecan and cisplatin in treating patients with locally advanced cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma, Stage IB Cervical Cancer, Stage IIA Cervical Cancer
- Trial name
- NCT00054444
- Testing
- Topotecan Hydrochloride Liposomes, 3-Dimensional Conformal Radiation Therapy, Cisplatin
- Where
- 10 sites in United States
- Volunteers
- 11 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Cancer
Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer
This study will investigate if a shorter treatment course (known as "hypofractionation") for pelvic radiation is safe for women with endometrial cancer.
- Trial name
- NCT04683653
- Testing
- Hypofractionated Radiation, Clinical Follow-Up and Assessments
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Endometrium Cancer
Endometrial Cancer and Robotic-assisted Versus Traditional Laparoscopy
The aim of this study is to compare the robotic-assisted laparoscopic surgery to the traditional laparoscopic surgery in endometrial cancer patients.
- Trial name
- NCT01466777
- Testing
- Traditional surgery type, Robotic assisted laparoscopic surgery
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Head and Neck Cancer, Lung Cancer
Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
- Conditions
- Head and Neck Cancer, Lung Cancer, Breast Cancer, Abdominal Cancer
- Trial name
- CONFIGURE (NCT05524454)
- Testing
- Novel CBCT Imaging
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Varian, a Siemens Healthineers Company
Oligometastatic Hormone-Sensitive Prostate Cancer, Prostate Adenocarcinoma
Prospective Study on the Role of Radical Prostatectomy in Oligo-metastatic Hormone-sensitive Prostate Cancer in Patients on Androgen Deprivation Therapy
MAZINGA is a prospective, single-group pilot study evaluating disease control after robot-assisted radical prostatectomy with extended pelvic lymph-node dissection in men with oligometastatic hormone-sensitive prostate…
- Trial name
- MAZINGA (NCT07766486)
- Testing
- Robot-Assisted Radical Prostatectomy With Extended Pelvic Lymph-Node Dissection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Carcinoma, Transitional Cell, Transitional Cell Carcinoma of Renal Pelvis
The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study
The study is investigating the ability of UroGen's UGN-101 to treat urothelial carcinoma tumors from the upper urinary tract.
- Trial name
- Olympus (NCT02793128)
- Testing
- UGN-101 instillations
- Where
- 24 sites in United States, Israel
- Volunteers
- 71 people
- Sponsor
- UroGen Pharma Ltd.
Uterine Fibroids (UF), Menstrual Disorders
Hugo™ Robotic-Assisted Surgery (RAS) System in Gynecological Subjects (Embrace Gynecology)
The purpose of this research is to evaluate the safety and performance of the investigational Medtronic Hugo™ Robotic Assisted Surgery (RAS) system when used during hysterectomy procedures, including patients being treated for…
- Conditions
- Uterine Fibroids (UF), Menstrual Disorders, Adenomyosis of Uterus, Endometriosis
- Trial name
- Embrace Gyn (NCT07120945)
- Testing
- Robotic Assisted-Surgery (RAS) Hysterectomy
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- Medtronic - MITG
Cervical Cancer, Radiation Therapy Complication
Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies
This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation…
- Conditions
- Cervical Cancer, Radiation Therapy Complication, Pelvic Floor Disorders
- Trial name
- NCT07447895
- Testing
- Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Cincinnati
Ovarian Cancer (OvCa)
Rectosigmoid Lesion Excision vs. Resection: A Non-Inferiority Randomized Comparison in Advanced Ovarian Cancer
Colorectum is the most common site of metastasis in ovarian cancer. Regarding intestinal surgery, there is controversy over whether to choose bowel resection or tumor removal, and currently, there are no prospective randomized…
- Trial name
- RSEnTrail (NCT07616310)
- Testing
- Rectosigmoid Lesion Excision +tumor cell debulking surgery, Rectosigmoid Resection +tumor cell debulking surgery
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer, Rectum Neoplasm
Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial
Study Purpose: This study aims to understand how pelvic floor rehabilitation (PFR) after low anterior resection (LAR) surgery for rectal cancer affects bowel control and quality of life compared to usual care.
- Conditions
- Rectal Cancer, Rectum Neoplasm, Rectal Neoplasms, Rectal Adenocarcinoma
- Trial name
- PERECARE (NCT06524362)
- Testing
- Pelvic Floor Physiotherapy (PFR), Conventional group
- Where
- India
- Volunteers
- 77 people
- Sponsor
- GEM Hospital & Research Center
Prostate Carcinoma, Rectum Carcinoma
Effect of Irradiation Doses < 10 Gy and of Irradiated Bone Volume on the Variation of Blood Elements of the Complete Blood Count During and After Pelvic Irradiation
Bone marrow is one of the organs at risk of complications during irradiation due to its radiosensitivity. Hematopoietic toxicity remains one of the main toxicities during irradiation of pelvic lymph node areas, especially when…
- Conditions
- Prostate Carcinoma, Rectum Carcinoma, Anal Canal Carcinoma, Endometrium Carcinoma
- Trial name
- MIFADORESOL (NCT04626466)
- Testing
- Biological investigations
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut de cancérologie Strasbourg Europe