Clinical trials: Patients Outcomes
Multiple Sclerosis
Therapy Optimization in Multiple Sclerosis (MS)
The purpose of this study is to determine if higher compliance and adherence rates to drug therapy for MS result in better health outcomes than lower rates of therapy compliance and adherence.
- Trial name
- TOP MS (NCT00819000)
- Testing
- Glatiramer Acetate, IFN-beta 1a (IM), IFN-beta 1a (Subcutaneous), and IFN-beta 1b
- Where
- 3 sites in United States
- Volunteers
- 2,878 people
- Sponsor
- Teva Neuroscience, Inc.
Major Abdominal/GI Surgery
Effects of Nutritional Preconditioning on the Patient's Outcomes After Surgery
Malnutrition is a serious problem in patients undergoing major surgeries and has a direct association with increased morbidity, mortality, length of stay (LOS), increased readmissions and cost of care.
- Trial name
- NCT03692507
- Testing
- HMB, Protein and HMB, ERAS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Idiopathic Carpal Tunnel Syndrome
Comparison of Subjective Outcomes and Changes of Ultrasonographic Morphology of Median Nerves of Mini-open and Endoscopic Carpal Tunnel Release in Patients With Idiopathic Carpal Tunnel Syndrome
A few studies have shown that the mini-incision release technique decreases the pathologic swelling of the median nerve at the inlet of the carpal tunnel and increases the flattening ratio of the median nerve in the carpal…
- Trial name
- NCT01972165
- Testing
- Mini-incision carpal tunnel release, Endoscopic carpal tunnel release
- Where
- South Korea
- Volunteers
- 67 people
- Sponsor
- Yonsei University
Cleft Lip, Cleft Lip and Palate
Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate
The purpose of this study is to determine whether secondary (revision) surgery to the lip in patients with cleft lip and palate is effective in improving lip function and appearance.
- Trial name
- NCT00070811
- Testing
- Lip revision surgery
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Lumbar Disc Herniation
Outcomes After Chiropractic Spinal Manipulative Therapy With Lumbar Disc Herniation and Radiculopathy
In a study that was approved nine years ago (EK-22/2009) we could show (i) that spinal manipulative therapy (SMT) is a very effective and safe treatment for acute and chronic lumbar disc herniation (LDH); (ii) that SMT is as…
- Trial name
- NCT04305509
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- Balgrist University Hospital
Incontinence, Prostate Cancer
Urology Database to Evaluate Clinical Information and Improve Patient Care.
The purpose of initiating the Urology Database is to evaluate the outcomes of urology procedures and medical management to enhance the care and treatment of urology patients.
- Conditions
- Incontinence, Prostate Cancer, Interstitial Cystitis, Urinary Retention
- Trial name
- NCT00376298
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Kenneth Peters, MD
Cancer Survivor
Internet-Delivered Positive Affect Program in Managing Emotion in Young Adult Cancer Survivors
This pilot clinical trial studies how well an internet-delivered positive affect (PA) intervention works in managing emotion in young adult cancer survivors.
- Trial name
- NCT02832154
- Testing
- Internet-Based Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Venous Insufficiency
VAP-PRO-C6. Effectiveness and Tolerability of Venoactive Drugs in Combination Therapy in Patients With CVD (CEAP C6)
The VAP-PRO-C6 is a Russian multicenter observational program to be implemented at the routine visits and assessments. The program will include patients with chronic venous disease of CEAP classes C6.
- Trial name
- VAP-PRO-C6 (NCT04757766)
- Testing
- in daily everyday routine practice
- Where
- Russia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Servier Russia
Chronic Obstructive Pulmonary Disease
PASS to Assess Cardiovascular and Cerebrovascular Events in COPD Patients Initiating Fixed Triple Therapy (DPI or pMDI)
The aim of this Post Authorisation Safety Study (PASS) is to assess the incidence of adverse cardiovascular and cerebrovascular events in COPD patients who are new to inhaled fixed triple therapy (dual bronchodilator plus…
- Trial name
- TRIBE (NCT05652439)
- Testing
- Observational retrospective data collection
- Where
- United Kingdom
- Volunteers
- 25,000 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Eating Disorders
Does Self-Efficacy at the Start of Treatment Influence Treatment Outcome in Patients With EDs?
The goal of this clinical trial is to contribute to the improvement of treatment for eating disorders, by identifying factors that might positively affect treatment outcome. The main questions it aims to answer are: 1.
- Trial name
- NCT06790030
- Testing
- CBT-T
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Altrecht
Prostate Cancer
New Treatment Modalities for Localized Prostate Cancer
The purpose of this study is to evaluate the effectiveness of four of the nowadays most established primary treatments for patients with clinically localized prostate cancer (active surveillance, robot-assisted radical…
- Trial name
- TTOPROST/OBS (NCT05523856)
- Testing
- Active Surveillance, Robot-Assisted Radical Prostatectomy, Intensity-Modulated Radiotherapy
- Volunteers
- 480 people
- Sponsor
- Fundacion IMIM
Relapsing Forms of Multiple Sclerosis
A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis
The purpose of this study is to evaluate the change in patient-reported outcomes, physician assessment of a change as well as safety and tolerability in patients with Relapsing Forms of Multiple Sclerosis on previous Disease…
- Trial name
- EPOC (NCT01216072)
- Testing
- Fingolimod, Standard MS DMTs
- Where
- 149 sites in United States, Canada and 1 more
- Volunteers
- 1,053 people
- Sponsor
- Novartis Pharmaceuticals
Rehabilitation, Stroke
Tele-rehabilitation for Cognitive Disorders
The aim of the study is to evaluate whether a computer-based cognitive treatment delivered via tele-rehabilitation produces an improvement in cognitive functioning comparable to the improvement achievable through the same…
- Conditions
- Rehabilitation, Stroke, Telerehabilitation, Telemedicine
- Trial name
- NCT06795672
- Testing
- Telerehabilitation, Traditional in-person rehabilitation.
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Universita di Verona
Gynaecological Oncology
Survival Outcomes of Gynecologic Oncology Patients at Assiut University
This retrospective cohort study investigates survival outcomes of gynecological oncology patients treated at Assiut University Hospital between 2022 and 2025, comparing them to international benchmarks and assessing factors…
- Trial name
- NCT07232212
- Volunteers
- 200 people
- Sponsor
- Assiut University
Medication Adherence, Blood Pressure
The Effect of Medication Reminder Technology on Medication Adherence and Hypertension Outcomes
This study to evaluates how a med reminder affects the patient's ability to take medications as prescribed
- Trial name
- NCT01755312
- Testing
- Medication reminder
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Purdue University
Chest Pain, Coronary Artery Disease
Coronary Computed Tomographic Angiography Combined With CT-FFR in Intermediate-Risk Chest Pain Patients.
This study aims to investigate the guiding value of coronary CTA combined with CT-FFR in diagnostic and treatment decision-making for emergency chest pain patients at moderate risk, as well as its impact on clinical outcomes.
- Conditions
- Chest Pain, Coronary Artery Disease, Emergency Department
- Trial name
- E-CCTA (NCT07140419)
- Testing
- Coronary computed tomographic angiography with CT - derived fractional flow reserve
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Qilu Hospital of Shandong University
Cardiogenic Shock, PCI Patients
Clinical Outcomes of Contemporary IMPELLA Devices in Cardiogenic Shock and High-risk Percutaneous Coronary Intervention
The IMMERGE registry is an observational, international multicentric study, including patients underwent IMPELLA implantation in the participating centers both for cardiogenic shock and high-risk PCI.
- Conditions
- Cardiogenic Shock, PCI Patients, Mechanical Circulatory Support
- Trial name
- IMMERGE (NCT06690567)
- Testing
- Impella implantation
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Stroke
Ipsihand Device Use in Stroke Patients to Assess Functional Motor Outcomes
This study aims to evaluate the impact of the Neurolutions Upper Extremity Rehabilitation System, known as IpsiHand, on improving functional motor control for post-stroke patients with hemiparesis.
- Trial name
- NCT04338971
- Testing
- IpsiHand Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Neurolutions, Inc.
Heart Failure, Systolic
Patient Reported Outcomes inVestigation Following Initiation of Drug Therapy With Entresto (Sacubitril/Valsartan) in Heart Failure
Real-world evidence of the clinical course of patient symptoms following initiation of sacubitril/valsartan via PROs with a patient-centered study design will provide important evidence of potentially beneficial outcomes…
- Trial name
- PROVIDE-HF (NCT03387163)
- Testing
- Sacubitril/Valsartan
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Novartis Pharmaceuticals
Transplant, Adaptive Immunity
CNTRP POSITIVE Study
Adequate control of immunosuppression is critical in preventing graft failure after solid organ transplantation (SOT) and in avoiding life-threatening viral and malignant complications.
- Conditions
- Transplant, Adaptive Immunity, EBV, Medication Adherence
- Trial name
- NCT02318030
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children