Clinical trials: Patient-Controlled Analgesia, open to volunteers
Breast Surgery
Serratus Posterior Superior Intercostal Plane Block, Versus Erector Spinae Facial Plane Blocks
Mastectomy is currently the most effective treatment for breast cancers in women. postoperative pain management carries a high degree of difficulty, as the breast has complex innervation involving the intercostal (T1-T7)…
- Trial name
- NCT06989372
- Testing
- serratus posterior superior block, erector spinae block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Analgesia Obstetrical, Analgesia
Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia
Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology.
- Conditions
- Analgesia Obstetrical, Analgesia, Post Operative Pain, Patient Satisfaction
- Trial name
- NCT07386353
- Testing
- Intrathecal Morphine, Epidural Morphine
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Central do Funchal
Postoperative Pain; Knee Arthroscopy; Acupuncture
Acupuncture for Pain Control After Ambulatory Knee Arthroscopy
Aim of the study: To investigate whether acupuncture with indwelling fixed needles reduces pain and analgesic requirement and foster mobilization in patients after arthroscopic knee surgery (AKS) Design: Prospective pilot…
- Trial name
- AcuK-Scope (NCT04134702)
- Testing
- Acupuncture
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Obese Patients
External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing…
- Trial name
- NCT07809425
- Testing
- Investigatore hypothesize that adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption., Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate).
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Pain Management, Arthroplasty
Effect of Preoperative Pain Education on Anxiety, Pain, and Analgesic Use in Total Knee and Hip Replacement Patients
This randomized controlled trial evaluates whether a standardized preoperative pain education session delivered by a nurse reduces postoperative pain intensity and surgical anxiety among adult elective orthopedic surgery patients…
- Conditions
- Pain Management, Arthroplasty, Knee Replacement, Hip Replacement
- Trial name
- Pain-Anxiety (NCT07362589)
- Testing
- Pain education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yeditepe University
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Postoperative Acute Pain
Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy
A single-center, randomized, double-blind, placebo-controlled trial design will be adopted to investigate whether Anruikefon can significantly reduce the consumption of sufentanil via PCIA pumps within 48 hours postoperatively…
- Trial name
- NCT07801183
- Testing
- Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Total Knee Anthroplasty, Epidural Analgesia
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty
The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery.
- Trial name
- NCT07605208
- Testing
- Programmed intermittent epidural bolus 6 ml, continuous epidural infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sakarya University
Provide Post Hepatectomy Pain Control
Bilateral External Oblique Intercostal Plane Block in Post Operative Pain Management in Hepatectomy
The majority of cases undergoing hepatectomy suffer from inadequate postoperative analgesia. Therefore, multimodal analgesic techniques are required to relieve pain and discomfort such as intravenous, and epidural analgesia, and…
- Trial name
- EOI (NCT06822309)
- Testing
- External Oblique Intercostal Plane Block, Patient controlled analgesia
- Volunteers
- 40 people
- Sponsor
- Sherif Alaa Embaby
Laparoscopic Cholecystectomy, Postoperative Pain
Subcostal TAP Block Versus Combined Subcostal TAP and Recto-Intercostal Fascial Plane Block for Analgesia After Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is commonly associated with moderate postoperative pain, particularly during the early postoperative period.
- Trial name
- NCT07869316
- Testing
- Subcostal Transversus Abdominis Plane Block, Recto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Postoperative Pain
PENG Block Versus Intrathecal Morphine for Early Postoperative Recovery After Total Hip Arthroplasty
The goal of this clinical trial is to compare the PENG block with intrathecal morphine for early postoperative recovery and pain control in adults undergoing elective total hip arthroplasty.
- Trial name
- NCT07803133
- Testing
- Pericapsular nerve group (PENG) block, Intrathecal Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Postoperative Delirium
The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery
To explore the effects of bupivacaine liposomes in preemptive analgesia for iliofascial block on postoperative pain and postoperative delirium in elderly patients with hip fractures, to optimize perioperative analgesia…
- Trial name
- NCT07066111
- Testing
- Tramadol, bupivacaine liposome (ultrasound-guided high iliofascial space block)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Opioid Consumption, Postoperative, Pain, Postoperative
Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques
This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over…
- Conditions
- Opioid Consumption, Postoperative, Pain, Postoperative, Nerve Block, PENG Block
- Trial name
- NCT06821516
- Testing
- Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Sedation Complication, Mechanical Ventilation Complication
Effect of Goal-directed Analgesia and Sedation Using EEG Derived QCON/qNOX in ICU Patients
Sedation and analgesia are fundamental tools for managing critical patients who require mechanical ventilation. However, recent scientific literature highlights that excessive sedation in these patients can increase the duration…
- Trial name
- SED_ICU (NCT06769308)
- Testing
- Sedation titration according to qEEG, Sedation titration according to standard of care
- Where
- 2 sites in Italy
- Volunteers
- 174 people
- Sponsor
- Università degli Studi di Ferrara
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Patients Undergoing Major Laparoscopic Abdominal Surgery
Intrathecal Morphine for Postoperative Analgesia in Major Laparoscopic Abdominal Surgery, a IMPACT-Scope Trial
The goal of this clinical trial is to learn the clinical and cost effectiveness of intrathecal morphine (ITM) in addition to usual care as a postoperative pain relief strategy following major laparoscopic abdominal surgery…
- Trial name
- IMPACT-Scope (NCT06666985)
- Testing
- ITM + Usual Care
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pancreatoduodenectomy, Pain Management
Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
The goal of this clinical trial is to determine whether continuous nefopam administration, as part of a multimodal analgesia strategy, reduces opioid consumption and improves patient satisfaction after pancreatoduodenectomy.
- Conditions
- Pancreatoduodenectomy, Pain Management, Opioid Analgesia, Multimodal Analgesia
- Trial name
- NCT07423650
- Testing
- Nefopam 120mg/day infusion, Lidocaine Infusion, Peridural
- Where
- Romania
- Volunteers
- 93 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Postoperative Pain, Pain Management
Comparison of Two Postoperative Care Strategies After Breast Surgery
The goal of this clinical trial is to compare two postoperative analgesia strategies in adult women undergoing breast surgery and to evaluate their effects on postoperative pain and quality of recovery after hospital discharge.
- Conditions
- Postoperative Pain, Pain Management, Breast Surgery, Chronic Postoperative Pain
- Trial name
- NCT07880223
- Testing
- Patient Education, Paracetamol, Dexketoprofen
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Moumtzidou Maria Aikaterini
PONV, Cerebellopontine Angle Tumor
Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery
This single-center, double-blind, randomized controlled trial aims to determine whether oliceridine for patient-controlled intravenous analgesia (PCIA) can significantly reduce the incidence of postoperative nausea, an…
- Conditions
- PONV, Cerebellopontine Angle Tumor, Microvascular Decompression Surgery, Postoperative Analgesia
- Trial name
- NCT07479446
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Xuanwu Hospital, Beijing
Organ Dysfunction, Organ Support
Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction
Acute pancreatitis may cause early respiratory, cardiovascular, or renal dysfunction and may require intensive care and organ support.
- Conditions
- Organ Dysfunction, Organ Support, Acute Pancreatitis (AP)
- Trial name
- TEA-APOD (NCT07697690)
- Testing
- Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia
- Volunteers
- 150 people
- Sponsor
- First People's Hospital of Chenzhou