Clinical trials: Pathologic Myopia
Pseudophakia, Hypermetropia
Treatment of Residual Hypermetropic Refraction on Pseudophakic Patients Using Allogenic Fresh Myopic Lenticule
The residual hypermetropic refraction on pseudophakic(Trifocal IOL) patients is difficult to treat surgically. In addition, there are not many suitable options to offer such patients presenting with this condition.
- Conditions
- Pseudophakia, Hypermetropia, Myopia
- Trial name
- ReLex-Smile (NCT04692012)
- Testing
- FRESH CORNEAL MYOPIC LENTICULE IMPLANTATION
- Where
- Kosovo
- Volunteers
- 34 people
- Sponsor
- Eye Hospital Pristina Kosovo
Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness)
Effect of Presbyopia Correction on Livelihood and Repayment Among Solar Customers in Western Region, Kenya
With age, people lose the ability to see things that are near them clearly. This is known as presbyopia. Although this is a normal ageing process, it can be corrected with near vision eyeglasses - colloquially known as reading…
- Conditions
- Presbyopia Correction, Visual Impairment and Blindness (Excl Colour Blindness), Repayment Behaviour, Livelihoods
- Trial name
- NCT06774183
- Testing
- Near vision glasses for presbyopia correction
- Volunteers
- 1,085 people
- Sponsor
- Dot Glasses Kenya
Myopia, Degenerative
Early Vitrectomy for Macular Tractional Maculopathy
This study is designed to identify the effect of current vitreous surgery for symptomatic macular tractional maculopathy. Characteristics of this study is as below 1. Multicenter, prospective clinical trial.
- Trial name
- NCT01121978
- Testing
- Early vitrectomy
- Where
- 10 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul Retina Investigator Group
Choroidal Neovascularization
Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV)
To evaluate the effect of bevacizumab for treatment of non-AMD choroidal neovascularization (CNV); eg:angioid streaks, ocular histoplasmosis, high myopia, idiopathic,etc
- Trial name
- NCT00370786
- Testing
- bevacizumab
- Where
- Iran
- Volunteers
- 31 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Choroidal Subfoveal/Juxtafoveal Neovascularization in High Myopia
Initial Treatment With Bevacizumab in Choroidal Neovascularization Associated to High Myopia
The purpose of this protocol is to determine wether the initial protocol in the treatment of subfoveal choroidal neovascularization associated to High Myopia with bevacizumab intravitreal injections is more effective when using 3…
- Trial name
- BENEMCOR (NCT01716026)
- Testing
- Bevazizumab intravitreal injection
- Where
- 11 sites in Spain
- Volunteers
- 66 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Myopia
Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain
Compare the use of codeine/paracetamol against placebo for pain control after cornea photorefractive keratectomy (PRK).
- Trial name
- NCT02625753
- Testing
- Codeine, paracetamol
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Presbyopia, Pseudophakia
A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects
The objective of this study is to evaluate the safety and effectiveness of the Raindrop Near Vision Inlay implanted in bilateral pseudophakes with presbyopia for improvement of near and intermediate vision.
- Trial name
- NCT02668523
- Testing
- Raindrop Near Vision Inlay
- Where
- 13 sites in United States
- Volunteers
- 400 people
- Sponsor
- ReVision Optics, Inc.
Myopic Choroidal Neovascularisation
Intravitreal Conbercept Injection in Patients With Myopic Choroidal Neovascularization
Choroidal neovascularization (CNV) secondary to pathologic myopia (PM-CNV) is a common vision-threatening complication and often affects adults of working age.
- Trial name
- NCT03971162
- Testing
- 3+PRN, 6+PRN
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia, Obesity
Trial of a Novel Family-Based Intervention to Increase Outdoor Time and Fitness
This study aims to implement a new family-based health behavior community program to increase time spent outdoors and physical activity among Singapore children aged 6 to 12 years in a 1-year randomized clinical trial.
- Trial name
- FIT (NCT01388205)
- Testing
- Family-based Outdoor program
- Where
- Singapore
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Diabetic Retinopathy, Myopia
OCTA Metrics Repeatability and Reproducibility in Different Disorders
Retinal imaging is a corner stone in diagnosis of most retinal disorders. Standard imaging techniques e.g. fluorescein angiography and color fundus photography have a lot of limitations including limited resolution, invasive…
- Conditions
- Diabetic Retinopathy, Myopia, Choroidal Neovascularization, Healthy
- Trial name
- NCT04488887
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
High Myopia
Shanghai High Myopia Study for Adults
High myopia retinopathy has become the first cause of irreversible blindness and severe visual impairment in Chinese adults, in order to avoid the blind and visual impairment caused by high myopia retinopathy, it is very…
- Trial name
- SHMSA (NCT03446300)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Degenerative
Reduced-fluence Verteporfin Photodynamic Therapy Plus Ranibizumab for Choroidal Neovascularization in Pathologic Myopia
To demonstrate the efficacy of ranibizumab in combination with reduced-fluence verteporfin photodynamic therapy (RF-PDT) in patients with subfoveal choroidal neovascularization secondary to pathologic myopia (PM).
- Trial name
- NCT01968486
- Testing
- PDT standard fluence, ranibizumab, PDT reduced fluence, ranibizumab, ranibizumab
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cerebral Visual Impairment, Refractive and Accommodative Disorders
Babies in Glasses; a Feasibility Study.
This is a feasibility study to begin investigating the possibility that early use of near vision glasses will improve vision in infants at risk of Cerebral Visual Impairment (CVI), leading to further improvement in other areas of…
- Conditions
- Cerebral Visual Impairment, Refractive and Accommodative Disorders, Hypoxic-Ischemic Encephalopathy, Premature Birth
- Trial name
- BiG (NCT05048550)
- Testing
- Near vision spectacles
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Myopia
Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness…
- Trial name
- NCT04631991
- Testing
- Comprehensive ophthalmologic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Akdeniz University
Pseudophakia, Myopia
Treatment of Residual Myopic Refraction After 6 Months on Pseudophakic Patients Using Relex-Smile
The aim of this study is to assess visual and refractive outcomes after laser vision correction (LVC) - ReLex Smile to correct residual myopic refraction after 6 months of pseudophakic (IOL) implantation.
- Trial name
- Relex-Smile (NCT04693663)
- Testing
- Relex-Smile surgery
- Where
- Kosovo
- Volunteers
- 20 people
- Sponsor
- Eye Hospital Pristina Kosovo
Pathologic Myopia
High Myopia: Extended and Longterm Observation of Pathologic Myopia Patients With the Risk for Developing a Myopic Choroidal Neovascularization (CNV)
This research project intends to observe patients with high myopia who show pathological retinal changes, in order to evaluate more data on the risk factors for developing mCNV within this research project population in Germany.
- Trial name
- HELP (NCT03070717)
- Testing
- Observation & Diagnosis
- Where
- 26 sites in Germany
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Refractive Errors
Clinical Evaluation of Acuity 200 (Fluoroxyfocon A) RGP Contact Lens
The objective of this clinical investigation is to collect valid scientific safety and effectiveness data on the Acuity 200 (fluoroxyfocon A) Rigid Gas Permeable Contact Lens, manufactured from a newly developed rigid gas…
- Trial name
- Acuity 200 (NCT03971227)
- Testing
- Acuity 200 (Fluoroxyfocon A) contact lens, Acuity 100 (Hexafocon A) contact lens
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Acuity Polymers, Inc.
Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or,, Large Size Macular Hole (Diameter > 600 Microns) or
The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes
The purpose of this study is to determine the effectiveness of intravitreal autologous platelet concentrate (APC) injection during the surgery for refractory macular holes.
- Conditions
- Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or,, Large Size Macular Hole (Diameter > 600 Microns) or, Recurred or Failed Macular Hole From Previous Surgery, or Chronic Macular Hole (Symptom Duration > 6 Months)
- Trial name
- NCT02081170
- Testing
- Autologous platelet concentrate
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Cataract, Presbyopia
Retrospective Clinical Investigation of the Safety and Performance of 640PM Trifocal IOL Implantation in Patients With Cataract and/or Ametropia (Hyperopia, Myopia) and/or Presbyopia
The clinical investigation objective is to evaluate safety and performance outcomes of trifocal IOL implantation to improve vision in patients with cataract and/or ametropia (hyperopia, myopia) and/or presbyopia.
- Conditions
- Cataract, Presbyopia, Hyperopia, Myopia
- Trial name
- NCT05735990
- Testing
- Intraocular lens
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Medicontur Medical Engineering Ltd