Clinical trials: Passive Leg Raising
Fluid Responsiveness
Evaluation of Perfusion Index Change Post Passive Leg Raising for Fluid Responsiveness in Critically Ill
Peripheral Perfusion Index (PI) has been investigated for its use in hemodynamic monitoring. The PI is derived from the photoelectric plethysmographic signal of the pulse oximeter.
- Trial name
- NCT06063993
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Arthroscopic Shoulder Surgery
Hemodynamic Changes With Passive Leg Raising Maneuver in Patients Undergoing Arthroscopic Shoulder Surgery
After intubation of the patients who are undergoing arthroscopic shoulder surgery, plethysmographic waveform will be recorded with blood pressure, heart rate and end-tidal carbon dioxide values and inferior vena cava (IVC)…
- Trial name
- NCT04152135
- Testing
- vena cava inferior diameter measurement
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Shock, Acute Circulatory Failure
Applicability of Fluid Responsiveness Indices in Circulatory Failure (AFRIC Study) Study Project
Fluid administration is one of the main strategies for patients with acute circulatory failure. However, about half of the patients could not benefit from the fluid administration after the ICU admission.
- Trial name
- AFRIC (NCT05046340)
- Testing
- Passive leg raising
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Bicetre Hospital
Shock, Septic
Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test
A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain.
- Trial name
- OFTaPLR (NCT02301585)
- Testing
- Passive Leg Raising Test, Standard of care
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
Cardiac Surgery
Study of Perioperative Evolution of Right Heart Dysfunction and Preload Responsiveness in Open Heart Cardiac Surgery
The aim of the study was to assess the ability a Lung Recruitment Maneuver (LRM) with a stepwise increase of PEEP to predict fluid responsiveness and right cardiac dysfunction in mechanically ventilated patients in open heart…
- Trial name
- NCT04711798
- Testing
- passive leg raising maneuver (PLR), lung recruitment maneuver (LRM), echographic evaluation of the right cardiac function
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation
Alveolar Recruitment Maneuver-Induced Hypotension: A Dynamic Consequence and Intraoperative Indicator of Fluid Responsiveness
This study investigates whether two simple bedside tests - the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI) - can predict a drop in blood pressure that sometimes occurs during a lung-opening procedure…
- Conditions
- Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation, Atelectasis, Fluid Responsiveness
- Trial name
- NCT07766967
- Testing
- Alveolar Recruitment Maneuver (ARM), Passive Leg Raising (PLR) Test
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Maternity, Pregnancy
Passive Leg Raising in Term Pregnancy on Hemodynamic Monitoring - Validating With Transthoracic ECHO (LG-ECHO)
This prospective observational validation study aims to evaluate the agreement and diagnostic accuracy of ClearSight™ compared with transthoracic echocardiography (TTE) during PLR in term pregnant women.
- Conditions
- Maternity, Pregnancy, Labor and Delivery, Hemodynamic Changes
- Trial name
- (LG-ECHO) (NCT07253818)
- Testing
- ClearSight™ System, Transthoracic Echocardiography, Passive Leg Raising (PLR) Maneuver
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ayse Zeynep Turan Civraz
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Valvular Heart Surgery
Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising
Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation.
- Trial name
- NCT02224378
- Testing
- peep induced CVP, passive leg raising(PLR)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Circulatory Failure
Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients
Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO2) in the critically ill patients.
- Trial name
- PtcO2-FR (NCT02083757)
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Weaning, Spontaneous Breathing Trial
Prediction Of Pulmonary Edema With Müller Maneuver
The mechanical ventilation weaning must begin as early as possible to limit its complications and requires a spontaneous breathing trial (SBT) before the separation from the ventilator to the patient.
- Trial name
- PoEM (NCT05358405)
- Testing
- Müller maneuver
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Cardiac Complication
Fluid Responsiveness in Post Cardiac Surgery Patients
The aim of the study is to compare end expiratory occlusion test to passive leg raising test for prediction of fluid responsiveness in post cardiac surgery mechanically ventilated patients.
- Trial name
- Cardiac (NCT06583200)
- Testing
- End Expiratory Occlusion Test, Passive Leg Raising Test
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Venous Congestion
Portal Vein Pulsatility Index to Assess Fluid Intolerance
This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.
- Trial name
- NCT06440772
- Testing
- Ringer's Lactate Crystalloid Solutions
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Hemodynamic Instability, Shock
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially.
- Conditions
- Hemodynamic Instability, Shock, Septic Shock
- Trial name
- VOLTA (NCT04089098)
- Testing
- passive leg raising versus mini volume challenge
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Leipzig
Cardiovascular Insufficiency
Passive Leg Raising - an Important Diagnostic Manoeuvre
The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre. The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after…
- Trial name
- PLR-ANS (NCT03454802)
- Testing
- Passive Leg Raising
- Where
- Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Region MidtJylland Denmark
Post-induction Hypotension (PIH), Gastrointestinal Tumor Surgery
Carotid Doppler Changes After Passive Leg Raising for Prediction of Post-Induction Hypotension in Gastrointestinal Tumor Surgery
This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid…
- Trial name
- PLR (NCT07777159)
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Ankara City Hospital Bilkent