Clinical trials: Parkinsonism
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Covid19, Neurologic Manifestations
Evaluation of Biological Response to SARS-COV2 (COVID-19) in Patients With Pre-existing Neurological Disease or Newly Neurological Symptoms (BIO-COCO-NEUROSCIENCES)
Patients with neurological or psychiatric symptoms or pre-existing disease will be sampled (blood for serum and DNA or saliva for DNA) at inclusion and at M6 (blood) and M12 (blood) depending on their pathology.
- Conditions
- Covid19, Neurologic Manifestations, Psychiatric Manifestations
- Trial name
- NCT04568707
- Testing
- blood sample
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Continuous Delivery of Levodopa in Patients With Advanced Idiopathic Parkinsons Disease - Cost-benefit
An open, observational health economic study to estimate marginal cost and health consequences of replacing conventional Parkinsons disease therapy with intraduodenal levodopa administered continuously
- Trial name
- NCT00272688
- Testing
- Levodopa (drug), intraduodenal administration
- Where
- 2 sites in Norway
- Volunteers
- 10 people
- Sponsor
- University Hospital, Akershus
Parkinson's Disease
Study to Evaluate the Safety and Efficacy of ESC-derived Dopamine Progenitor Cell Therapy in PD Patients
Indication: Patients who were diagnosed with Parkinson's disease ≥ 5 years ago. Purpose: To find the maximum tolerable dose and evaluate the safety and exploratory efficacy of allogenic embryonic stem cell-derived A9 dopamine…
- Trial name
- NCT05887466
- Testing
- Allogenic embryonic stem cell-derived A9 dopamine progenitor cell (A9-DPC) Low Dose, Allogenic embryonic stem cell-derived A9 dopamine progenitor cell (A9-DPC) High Dose
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- S.Biomedics Co., Ltd.
Parkinson Disease
Trial of Probiotics for Constipation in Parkinson's Disease
This is a double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics in the treatment of constipation in Parkinson's disease.
- Trial name
- NCT03377322
- Testing
- Probiotic Capsule
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- University of Malaya
Parkinson Disease
A Late Phase II Clinical Trial of KDT-3594 in Patients With Parkinson's Disease
This trial is a late phase II, multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy, safety, and pharmacokinetics of KDT-3594 administered at escalating doses ranging from 0.25…
- Trial name
- NCT06722729
- Testing
- KDT-3594
- Where
- Japan
- Volunteers
- 178 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies
- Trial name
- NAPS2 (NCT05826457)
- Where
- 9 sites in United States, Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB)
Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies
Progressive supranuclear palsy (PSP), mild cognitive impairment with Lewy bodies (MCI-LB), and Dementia with Lewy Bodies (DLB) are severe neurodegenerative diseases that cause significant motor impairment impacting daily…
- Conditions
- Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB), PSP, Lewy Body Dementia (LBD)
- Trial name
- NCT07240805
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- BioSensics
Tremor, Essential Tremor
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS).
- Conditions
- Tremor, Essential Tremor, Parkinson Disease, Radiosurgery
- Trial name
- NCT01734122
- Testing
- Questionnaires / Observational Assessments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease, Dementia
A Study to Evaluate ENT-01 for the Treatment of Parkinson's Disease Dementia
This study will be conducted as a multi-center, open label study in the US. There will be 40 patient to receive the active investigational product.
- Trial name
- NCT03938922
- Testing
- Active Investigational Treatment ENT-01
- Where
- 3 sites in United States
- Sponsor
- Enterin Inc.
Parkinson Disease
Quality-of-Life Index (Q-Index)
The main objective of this observational study is to use commonly-used connected objects (smartphones and smartwatches) to remotely assess and monitor the health-related quality of life (HrQoL) of people with Parkinson's disease…
- Trial name
- NCT06209502
- Where
- 4 sites in Belgium
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Koios Care
Parkinson Disease
Amyloid Monoclonal Antibody Treatment in PD Patients With Coexistent AD Pathology
This study aimed to determine the efficacy of amyloid clearance of lecanemab in patients with Parkinson's disease (PD) with amyloid co-pathology.
- Trial name
- NCT07544953
- Testing
- Lecanemab, Lecanemab non-administration group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Hydrocephalus, Parkinson Disease
Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease
This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant…
- Conditions
- Hydrocephalus, Parkinson Disease, Walking, Difficulty, Movement Disorders
- Trial name
- HPGAIT (NCT05998473)
- Testing
- Dynamic stability measurement
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henri Mondor University Hospital
Apathy, Parkinson Disease
Effect of Istradefylline Treatment on Behavioral Measures of Apathy in Parkinson's Disease.
Apathy is defined as a lack of feeling, emotion, interest, or concern. Apathy also involves reduction or loss of motivation and goal-directed behavior.
- Trial name
- NCT05182151
- Testing
- Istradefylline 40 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease
Smartshoes for Freezing of Gait in Parkinson's Disease
This is a pilot research study aimed at evaluating whether an FDA listed wearable shoe with capability to deliver vibration feedback can be safe and tolerable for patients with Parkinson disease and control participants and…
- Trial name
- NCT07001072
- Testing
- Smartshoes with haptic vibration feedback
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease (PD)
Validation of α-synuclein Modifications in Parkinson's dIsoRder Evolution
Parkinson's disease (PD) presents a complex challenge due to its progressive neurodegenerative nature, affecting various bodily systems.
- Trial name
- VaMPiRE (NCT06941012)
- Testing
- Blood draw for the laboratory assessment
- Where
- 4 sites in Greece, Italy and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Parkinson's Disease (PD)
An Open-label Study in Healthy Male Subjects to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 9-1067 and Metabolites
The purpose of this study is to determine the rate and routes of excretion of OPC and the mass balance in urine, faeces and expired air.
- Trial name
- NCT02169427
- Testing
- OPC
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease
Ioflupane I123 (DaTSCAN) and Positron Emission Tomography-computed Tomography Fludeoxyglucose (PET-CT FDG) to Assess Brain Function of Parkinson Patients' First Degree Relatives
Parkinson Disease is one of the most common neurodegenerative illnesses. First degree relatives of Parkinson patient are in high risk for developing the disease.
- Trial name
- NCT01089270
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson Disease
Validation of a Diagnostic Self-assessment Scale Non-motor Fluctuations at the Parkinson's Patient
The objective of this study is to validate a diagnostic tool severity of these common non-motor manifestations, disturbing and little recognized as a self-questionnaire.
- Trial name
- NCT02859805
- Testing
- validation of a diagnostic tool severity of non-motor symptoms in Parkinson patients
- Volunteers
- 255 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson Disease
Pramipexole Conversion to Ropinirole Controlled Release (CR)
A conversion study of Mirapex (pramipexole) to Requip (ropinirole) controlled release (CR) in patients with Parkinson's disease to determine the appropriate conversion ratio and side effects related to the drug.
- Trial name
- NCT00275275
- Testing
- Requip PR, Mirapex
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Rajesh Pahwa, MD
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