Clinical trials: Parkinsonism
Parkinson Disease
Balance Tele-Rehab in Parkinson's Disease
This project will determine the feasibility and efficacy of remote assessment and treatment of balance disorders in people with Parkinson's disease.
- Trial name
- NCT05680597
- Testing
- Balance Tele-Rehabilitation Agility Boot Camp (ABC)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
MAPT Haploid H1b and the Damage of BBB in Dorsal Medulla Oblongata and Autonomic Dysfunction in PD
This study mainly explored the relationship between the permeability of the blood-brain barrier in the dorsal medulla oblongata and autonomic dysfunction, and the relationship and mechanism of MAPT genotype on the permeability of…
- Trial name
- NCT05471713
- Testing
- Autonomic dysfunction
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Parkinson's Disease (PD)
Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Benserazide
The purpose of this study is to determine the effect of three single oral doses of nebicapone (50 mg, 100 mg and 200 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled release…
- Trial name
- NCT02778594
- Testing
- BIA 3-202, levodopa 100 mg / benserazide 25 mg
- Where
- Portugal
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease
Emotional Prosody Treatment in Parkinson's
This study investigates a treatment protocol which holds the potential to significantly improve communication and quality of life for individuals affected by Parkinson's disease (PD).
- Trial name
- NCT01956266
- Testing
- Emotional prosodic treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Neurological Disease
Development, Reliability and Validity of the Telerehabilitation Usability Questionnaire- TrUQ
Neurological diseases are central nervous system diseases that cause an increase in the level of disability and limitations in daily life.
- Trial name
- NCT05970939
- Testing
- Development of the Telerehabilitation Usability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Gazi University
Parkinson's Disease
Effect of Deep Brain Stimulation on Depression and Quality of Life in Parkinson's Patients
We will evaluate the effect of deep brain stimulation on the depression and quality of life in Parkinson's disease. We aim to compare depression pre-operatively and post-operatively in Parkinson's patients with deep brain…
- Trial name
- NCT00179101
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Vanderbilt University
Parkinson Disease
A Phase I Study of TRN501 in Healthy Volunteers
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of TRN501 following a single administration of TRN501 or placebo to healthy adult male volunteers.
- Trial name
- NCT06453551
- Testing
- TRN501 - Dose 1, TRN501 - Dose 2, TRN501 - Dose 3
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- SNLD, Ltd.
Parkinson Disease
Compensation Mechanisms in Parkinson's Disease
Parkinson's disease onset is clinically defined as the appearance of motor symptoms including akinesia, tremor and hypertonia. Several studies have shown that motor symptoms occur when at least 50 % of dopaminergic neurons are…
- Trial name
- DATACOMT (NCT02869945)
- Testing
- Identification of COMT HH, COMT HL or COMT LL genes, Brain MRI with resting state scan, Brain MPET
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Precision Sensorimotor Neurorehabilitation Through Personalized Stimulation Loops
Parkinson's disease (PD) is a neurodegenerative disease that affects about 1% of the elderly population and accounts for substantial disability and health care costs.
- Trial name
- StimuLOOP-PD (NCT06608875)
- Testing
- Hyper-personalized feedback (HPF intervention), Targeted auditory stimulation during sleep (TASS verum intervention)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Alzheimer's Disease, Dementia With Lewy Bodies
Imaging of Brain Amyloid Plaques in the Aging Population
This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in…
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia
- Trial name
- NCT00950430
- Testing
- Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease
Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as…
- Trial name
- POWER-PD (NCT07095400)
- Testing
- strength training
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Universidad Villanueva
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Parkinson Disease, Idiopathic Parkinson Disease
Physiological Effects of Nutritional Support in Patients With Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder of unknown cause that affects more than a million Americans. It's most prominent pathology is the degeneration of dopaminergic neurons in the brain.
- Trial name
- NCT02445651
- Testing
- Intravenous and Oral n-acetyl cysteine, Control group, Oral Supplements: Baicalin, Ganoderma, Omega 3 and Curcumin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Thomas Jefferson University
Parkinson's Disease (PD), Parkinson Disease 6, Early-Onset
Phase Ⅲ Clinical Trial to Evaluate the Efficacy and Safety of TJ0113 Capsules in Patients With Early-Onset Parkinson's Disease
This study is a randomized, double-blind, multicenter, placebo-controlled Phase III clinical trial designed to evaluate the efficacy, safety, and Pop PK characteristics of TJ0113 Capsules in treating EOPD patients.
- Trial name
- NCT07741045
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hangzhou PhecdaMed Co., Ltd.
Parkinson Disease
Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire
Development and validation of a diagnosis questionnaire of parkinsonian primary pain: the "Primary Parkinsonian Pain Diagnostic Questionnaire" (3PDQ)
- Trial name
- 3PDQ (NCT03940872)
- Testing
- Self-questionnaire 3PDQ
- Where
- 10 sites in France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease
Strategy for Daily Activity Improvement in Patients With Parkinson's Disease
The symptoms and signs of patients with Parkinson's disease (PD) include bradykinesia, rigidity, tremor and poor sensory integration, which result in mobility disability.
- Trial name
- Parkinson (NCT03972241)
- Testing
- foot insole
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kwan-Hwa Lin
Parkinson's Disease, Physical Activity
Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients
There are experimental evidences of the important role of high intensity physical exercise in Parkinson's disease (PD) treatment, that induces similar effects to pharmacotherapy.
- Conditions
- Parkinson's Disease, Physical Activity, Neurorehabilitation, Neuroplasticity
- Trial name
- NCT04204551
- Testing
- high-intensity interval training (HIIT), conventional physical therapy
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Lewy Body Dementia
Non-invasive Transcranial Focused Low-intensity Ultrasound Stimulation in Patients With Mild Lewy Body Dementia
A randomized controlled clinical study was conducted in the xuanwu hospital Single Center of Capital Medical University to preliminarily explore the efficacy and safety of transcranial focused low-intensity ultrasound stimulation…
- Trial name
- tFUS in DLB (NCT05499429)
- Testing
- Transcranial low intensity focused ultrasound stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Voice Quality and Voice Loudness Associated With Parkinson's Disease
Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Therapy for PD-related Voice/Speech Impairment
This study will compare group singing to group speech therapy without singing. You may be eligible for this study if you have been diagnosed with PD for one year or more and you have a quiet voice or difficulty being understood.
- Trial name
- SING-PD (NCT01163331)
- Testing
- Singing Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Parkinson Disease, Parkinson Disease, Idiopathic
Step Up to PD: A Community-based Walking Program for People With Parkinson's Disease
This study will investigate the feasibility of a 6-month community walking program for people with Parkinson's disease (PD) and their care partners in greater Saint Louis, Missouri region.
- Trial name
- NCT06859528
- Testing
- Community Walking Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Louis University
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