Clinical trials: Parkinson's
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Parkinson Disease
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease
BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic…
- Trial name
- BioGenPark (NCT05384522)
- Testing
- blood samples collection
- Volunteers
- 103 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Deep Brain Stimulation, Parkinson Disease
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease.
- Trial name
- CLOSE-PD (NCT06909045)
- Testing
- Adaptive DBS, Continue DBS
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Parkinson Disease
Adaptive Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn if adaptive deep brain stimulation (DBS) can decrease or prevent freezing of gait in participants with Parkinson's disease.
- Trial name
- NCT06819020
- Testing
- Percept RC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Doris Wang, MD, PhD
PARKINSON DISEASE (Disorder)
Whole-Body Vibration Exercise in Patients With Parkinson's Disease
This study is a prospective, single-blind, randomized controlled trial designed to investigate the effects of whole-body vibration (WBV) exercise on balance, mobility, fall risk, and proprioception in patients with Parkinson's…
- Trial name
- NCT07472946
- Testing
- Whole-Body Vibration Plus Home Exercise, Home Exercise Only
- Volunteers
- 68 people
- Sponsor
- Istanbul University
Parkinson's Disease
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
This is a multi-center, randomized, double-blind, double-dummy, active controlled clinical Study. Following a screening period, eligible subjects will be enrolled to an open-label oral IR-LD/CD adjustment period; then an…
- Trial name
- BouNDless (NCT04006210)
- Testing
- ND0612 Solution for SC infusion, Oral IR-LD/CD
- Where
- 103 sites in United States, Austria and 14 more
- Volunteers
- 381 people
- Sponsor
- NeuroDerm Ltd.
Parkinson Disease
Comparison of Sensory Cuing Modalities for Freezing of Gait
The investigators intend to compare the effects on the resolution of visual and auditory sensory cues on the resolution of freezing of gait in patients with idiopathic Parkinson's disease.
- Trial name
- NCT05080413
- Testing
- Laser shoes, Metronome
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Veterans Health Service Medical Center, Seoul, Korea
PARKINSON DISEASE (Disorder)
Neural Correlates of Motor and Psychiatric Fluctuations in Parkinson's Disease
This study explores the electrophysiological mechanisms underlying motor and non-motor fluctuations (NMF) in Parkinson's disease (PD), focusing on cortical and subthalamic dynamics during acute dopaminergic stimulation.
- Trial name
- Transition STN (NCT07404241)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Parkinson Disease
Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease
Parkinson's disease (PD) is a neurological disorder that puts individuals at high risk for injuries and long-term disabilities as a result of a fall or other trauma.
- Trial name
- (OMT/PD) (NCT03616145)
- Testing
- Osteopathic Manipulative Treatment (OMT), Light Touch
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of California, San Diego
Movement Disorders, Parkinson Disease
Treatment of Parkinson's Disease With Eliprodil
Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This occurs as a result of destructive changes in an area of the brain responsible for making dopamine, the basal ganglia.
- Trial name
- NCT00001929
- Testing
- Eliprodil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Gait Disorders, Neurologic, Parkinson Disease
Adaptive SCS for Treatment of Gait Disturbance in PD
Spinal cord stimulation (SCS) has been suggested by several research for treating PD gait disturbance. However, the side effects induced by body position change cannot fully addressed by conventional SCS.
- Trial name
- NCT04538131
- Testing
- sensor-driven position-adaptive SCS, conventional SCS
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
A Prospective Cohort Study of Exercise Rehabilitation in the Treatment of Parkinson's Disease
The investigators proposed to conduct a cohort study to observe whether Tai Chi intervention could delay the disease progression of Parkinson's disease (PD).
- Trial name
- NCT05447975
- Testing
- Tai Chi training
- Volunteers
- 394 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Italian Translation and Validation of the Non-Motor Fluctuation Assessment (NoMoFA) Questionnaire: an Observational, Multicentric, Cross-sectional, 6-months Duration Study on 200 Consecutive Parkinson's Disease Patients.
Parkinson's disease (PD) has been traditionally considered a movement disorder. In fact, it is now recognized as a multisystemic disease involving not only the central nervous system and presenting with a constellation of motor…
- Trial name
- NoMoFA (NCT06406374)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery.
- Conditions
- Parkinson Disease (PD), Sleep Initiation and Maintenance Disorders, Deep Brain Stimulation
- Trial name
- NCT07903038
- Testing
- Lemborexant 5 mg, Placabo
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson's Disease
Cannabis and Parkinson's Disease Tremor: A Natural History Study
This is a prospective, observational study designed to describe the effects of Cannabis on Parkinson's Disease tremor.
- Trial name
- NCT02028858
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Bastyr University
Parkinson Disease
Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has developed into a standard therapy in the refractory stage of Parkinson's disease (PD).
- Trial name
- NCT03079960
- Testing
- Electrophysiological recording and measurement devices
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Prof. Dr. Volker Arnd Coenen
Parkinson Disease
Exercise Adherence and Optimal Nutrition Post Rehabilitation Among People With Parkinson's Disease
A randomized, controlled trial to evaluate the effect of six months digital follow-up, after a stay at a rehabilitation center, on functional and nutritional status in people with Parkinson Disease.
- Trial name
- mHEXANUT (NCT04945876)
- Testing
- Digital follow-up
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo Metropolitan University
Parkinson's Disease
ExAblate Transcranial MRgFUS of the Subthalamic Nucleus for Treatment of Parkinson's Disease
This is primarily a safety protocol to evaluate the safety of subthalamotomy using Transcranial ExAblate for treatment of Parkinson's Disease (PD) motor features.
- Trial name
- NCT02246374
- Testing
- ExAblate Transcranial System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- InSightec
Parkinson Disease
Effect of Noninvasive Brain Stimulation on Hypokinetic Dysarthria in Parkinson's Disease
Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD) patients and responds only partially to pharmacotherapy and surgery.
- Trial name
- NCT04203615
- Testing
- Transcranial magnetic stimulation- real rTMS
- Where
- Czechia
- Volunteers
- 39 people
- Sponsor
- Masaryk University
Parkinson's Disease, Parkinsonism
Modifiable Variables in Parkinsonism (MVP)
We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD…
- Conditions
- Parkinson's Disease, Parkinsonism, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT02194816
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Bastyr University
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