Clinical trials: Paraplegia
Paraplegia, Spinal, Paraplegia, Complete
Transcutaneous and Epidural Stimulation in SCI
The study seeks to improve the scientific understanding of how two electrical stimulation techniques, one which delivers electricity to the skin surface over the spine (transcutaneous electrical spinal stimulation [TESS]) and…
- Conditions
- Paraplegia, Spinal, Paraplegia, Complete, Paraplegia; Traumatic
- Trial name
- Service-Line (NCT04627441)
- Testing
- Transcutaneous spinal cord stimulator, Epidural spinal cord stimulator system
- Sponsor
- Kristin Zhao, PhD
Spinal Cord Injury, Able Bodied
Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury
Spinal cord injury (SCI) is a highly debilitating pathology, associated with the loss of sensorimotor functions, autonomy and quality of life.
- Conditions
- Spinal Cord Injury, Able Bodied, Traumatic Spinal Cord Injuries, Paraplegia, Spinal
- Trial name
- NCT07732868
- Testing
- Brain-Machine Interface
- Where
- 2 sites in Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- José Gabriel da Silva Figueiredo
Hereditary Spastic Paraplegia
Identification of Modifying Factors in Hereditary Spastic Paraplegia
A first questionnaire - MODIFSPA conducted in 2014 - identified several environmental factors influencing spasticity in HSP: cold, fatigue, and especially physical activity.
- Trial name
- MODIFSPA2 (NCT05373082)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 311 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Incomplete Spinal Cord Injury
The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients
The purpose of this study is to further establish safety and efficacy of the BQ EMF treatment of chronic SCI subjects who demonstrate stability in The Graded and Redefined Assessment of Strength, Sensibility and Prehension…
- Trial name
- NCT04050696
- Testing
- BQ 1.2
- Where
- 3 sites in United States, Israel
- Volunteers
- 8 people
- Sponsor
- BrainQ Technologies Ltd.
Hereditary Spastic Paraplegia
Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia (HSP) is a diverse group of genetic neurological conditions causing progressive weakness and spasticity in the lower limbs, severely reducing balance and gait capabilities.
- Trial name
- FRAME (NCT06742697)
- Testing
- Flexibility, Resistance, Aerobic, Movement Execution training
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Spinal Cord Infarction, Spinal Cord Stroke
Descriptive Study of Acute Spontaneous Spinal Cord Infarction
Acute spontaneous Spinal Cord Infarctions (SCI) are an uncommon cause of myelopathy (5%), but their prognostic is heterogeneous and frequently severe. Positive diagnosis is difficult, one quarter of initial MRIs are normal.
- Conditions
- Spinal Cord Infarction, Spinal Cord Stroke, Vascular Myelopathy
- Trial name
- EDMIAS (NCT04372758)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Spinal Cord Injury, Acute, Paraplegia
Functional Electrical Stimulation Cycling in SCI
Spinal cord injury (SCI) is a devastating, life-altering injury; requiring tremendous changes in an individual's lifestyle. Cycling, provides an ideal way for individuals with SCI to exercise and address the long-term…
- Conditions
- Spinal Cord Injury, Acute, Paraplegia, Tetraplegia
- Trial name
- NCT04064385
- Testing
- FES Cycling
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Glasgow Caledonian University
Paraplegia, Tetraplegia
Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.
- Conditions
- Paraplegia, Tetraplegia, Paralysis, Quadraplegia
- Trial name
- NCT05095454
- Testing
- Percutaneous epidural electrical spinal stimulation, Transcutaneous electrical spinal stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristin Zhao, PhD
Spinal Cord Injuries, Paraplegia
Multimodal Exercises to Improve Leg Function After Spinal Cord Injury
Many people with spinal cord injury (SCI) retain at least some movement below their injury, but their muscles often have a 'mind of their own'.
- Conditions
- Spinal Cord Injuries, Paraplegia, Paraparesis
- Trial name
- NCT01740128
- Testing
- Robotic body weight supported treadmill training, Harness-supported multimodal balance training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Acute Spinal Cord Injury
Stem Cells in Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled and delayed-start phase II/III clinical study.
- Conditions
- Spinal Cord Injuries, Acute Spinal Cord Injury, Paraplegia, Spinal, Paraplegia; Traumatic
- Trial name
- SCI2 (NCT03935724)
- Testing
- Neuro-Cells
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 16 people
- Sponsor
- Neuroplast
Paraplegia, Spinal Cord Injuries (SCI)
Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO)
ReWalk suit developed by Argo Medical Technologies is designed to enable people with lower limb disabilities to carry out routine ambulatory functions (stand, walk etc.); it can be used by people with disabilities such as spinal…
- Trial name
- NCT01251549
- Testing
- ReWalk - a motorized exoskeleton suit
- Where
- 2 sites in United States, Italy
- Volunteers
- 32 people
- Sponsor
- ReWalk Robotics, Inc.
Spinal Cord Injuries
Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments
The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians.
- Trial name
- NCT05643313
- Testing
- ABLE Exoskeleton
- Where
- 2 sites in Germany, Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Hereditary Spastic Paraplegia
12-Week Strength and Functional Exercise Program for Hereditary Spastic Paraplegia Trial (HSPMOVE)
This study aims to evaluate whether a 12-week program of strength and functional exercises can improve movement and daily function in people with Hereditary Spastic Paraplegia (HSP).
- Trial name
- HSPMOVE (NCT07561359)
- Testing
- Individualized Functional and Strength Exercises
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Spinal Cord Injuries, Paraplegia
Gait Training for Individuals With Paraplegia Using the H-MEX Exoskeleton
This study evaluates the feasibility and effects of H-MEX powered exoskeleton in individuals with paraplegia as a result of spinal cord injury.
- Trial name
- NCT04055610
- Testing
- Gait training using H-MEX exoskeleton
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Hanyang University Seoul Hospital
Spinal Cord Injury, Osteoporosis
Early Intervention to Reduce Bone Loss After Spinal Cord Injury
After a complete spinal cord injury (SCI), the patient becomes wheelchair-dependent, and the associated lack of weight-bearing and inactivity of paralysed muscles can lead to extensive bone loss in the long bones of the legs.
- Trial name
- NCT02334410
- Testing
- Whole body vibration (WBV)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Strathclyde