Clinical trials: Paraplegia, Spinal
Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to collect 650 blood and 300 cerebrospinal fluid (CSF) samples from people with amyotrophic lateral sclerosis (ALS), pure lower or upper motor neuron diseases, as well as other neurodegenerative…
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, Primary Lateral Sclerosis, Nervous System Diseases
- Trial name
- BIO_ALS-01 (NCT00677768)
- Testing
- No intervention
- Where
- 30 sites in United States, Canada
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injuries
Effectiveness of NEUROM and tDCS for Motor Recovery in Chronic Paraplegia
Traumatic Spinal Cord Injury (TSCI) is a catastrophic, unexpected, and devastating event that can occur along the spinal column (cervical, thoracic, and lumbar).
- Trial name
- NEUROM (NCT04790149)
- Testing
- Conventional Rehabilitation, NEUROM + tDCS, NEUROM
- Where
- Lebanon
- Volunteers
- 56 people
- Sponsor
- Lebanese University
Stroke, Spinal Cord Injuries (Complete and Incomplete)
Exoskeleton-assisted Neurorehabilitation
Objective assesment of the feasibility of integrating the Ekso Bionics - Ekso NR device into outpatient care Objective assesment of quality of life, functionality and clinical symptomps of patients with stroke, cerebellar ataxia…
- Conditions
- Stroke, Spinal Cord Injuries (Complete and Incomplete), Cerebellar Ataxia, Spastic Paraplegia
- Trial name
- NCT07352085
- Testing
- Gait training with exoskeleton
- Where
- Hungary
- Volunteers
- 5 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Spinal Cord Injury, Paraplegia
Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Subacute SCI
The purpose of this study is to assess the safety of autologous human Schwann cells (ahSC) transplantation in subjects with subacute SCI.
- Trial name
- NCT01739023
- Testing
- Autologous Human Schwann Cells
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- W. Dalton Dietrich
Cardiovascular Disease
Spinal Cord Injury: Endurance, Strength and Cardiac Function Induced by Efficient Training Protocols
1. Measurements of peak oxygen uptake (VO2peak) during passive leg cycling (PLC) combined with arm crank ergometry (ACE), leg vascular occlusion (100mmHg above systolic BP) combined with ACE, and FES isometric contractions…
- Trial name
- NCT00987155
- Testing
- Ergometry
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Paraplegia
High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04397250
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Spinal Cord Injury, Dyslipidemia
Fenofibrate Treatment in SCI
Cardiovascular disease-related morbidity in persons with spinal cord injury (SCI) occurs earlier in life, at a greater prevalence than that of the general population, and is the primary cause of death after the first year of…
- Trial name
- NCT02455336
- Testing
- Fenofibrate, No intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Paraplegia
Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia
Spinal cord injury (SCI)-related paraplegia is a complex neurological condition characterized by motor impairment, increased spasticity, and significant functional limitations in daily activities.
- Conditions
- Spinal Cord Injury, Paraplegia, Spasticity, Neurorehabilitation
- Trial name
- FES-PAR-RCT (NCT07583576)
- Testing
- Conventional Neurorehabilitation, Functional Electrical Stimulation (FES) of Quadriceps Muscle
- Volunteers
- 40 people
- Sponsor
- Istanbul Medipol University Hospital
Spinal Cord Injuries, Paraplegia, Complete
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
- Trial name
- E-STAND (NCT03026816)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Self-balancing Personal Exoskeleton for SCI (Site 2)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
- Trial name
- NCT06814015
- Testing
- Hands-free exoskeleton
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injuries, Paraplegia, Spinal
Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton
The central objective of this study is to validate new algorithms that coordinate between functional electrical stimulation (FES) and the exoskeleton during sitting-to-standing, walking, and standing-to-sitting movements.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
- Trial name
- NCT04453943
- Testing
- Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Motor Function, Gait
Spinal Cord Stimulation Therapy for Hereditary Spastic Paraplegias Patients
It's a single-center, prospective, open label clinical study with a 12 months follow-up period, to investigate the therapeutic effect and safety of spinal cord stimulation (SCS) on motor function and gait in patients with pure…
- Trial name
- NCT05196178
- Testing
- Spinal cord stimulation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Cord Injuries
Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians.
- Trial name
- NCT04876794
- Testing
- ABLE Exoskeleton
- Where
- 2 sites in Germany, Spain
- Volunteers
- 24 people
- Sponsor
- ABLE Human Motion S.L.
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with thoracolumbar chronic and complete spinal cord injury.
- Trial name
- NCT02574585
- Testing
- Autologous mesenchymal cells transplantation
- Volunteers
- 40 people
- Sponsor
- Hospital Sao Rafael
Paraplegia
High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04011137
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Hereditary Spastic Paraplegia
Neuromodulation to Enhance Motor Function in HSP
Hereditary spastic paraplegia (HSP) is a rare neurological condition that causes stiffness, weakness, and difficulty walking due to damage in the nerves that control movement.
- Trial name
- NCT07417943
- Testing
- transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rahul Sachdeva
Paraplegia and Tetraplegia
Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury
The purpose of this study is to evaluate whether there are functional improvements in arm muscles and movments for spinal cord injured indviduals after performing video gaming.
- Trial name
- NCT01537978
- Testing
- Video gaming for enhanced function after spinal cord injury.
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Spinal Cord Injuries, Paraplegia, Spinal
Activity-Dependent Transspinal Stimulation in SCI
Robotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient.
- Conditions
- Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, Spastic
- Trial name
- NCT03669302
- Testing
- Robotic gait training, Robotic gait training and low-frequency transspinal stimulation, Robotic gait training and high-frequency transspinal stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- City University of New York
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center