Clinical trials: Paralysis
Parkinson Disease
Quantification Tools for a Novel Tau PET Marker in a Rare Neurological Disease: 18F-PI-2620 in Progressive Supranuclear Palsy
The aim of this clinical trial is to explore the potential of novel 2nd generation tau PET radiotracers as biomarkers in cases suggestive of progressive supranuclear palsy (PSP), an atypical form of parkinsonism.
- Trial name
- Quanti-TAU-PET (NCT07105384)
- Testing
- Radiotracer
- Where
- Spain
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Progressive Supranuclear Palsy, Dementia With Lewy Bodies
In-Home Care for Patients With PSP and Related Disorders
Progressive Supranuclear Palsy and related disorders (PRD) are debilitating, costly, and understudied conditions. Improving access to comprehensive, specialized, in-home patient care offers the potential to minimize the downward…
- Conditions
- Progressive Supranuclear Palsy, Dementia With Lewy Bodies, Multiple System Atrophy, Corticobasal Syndrome
- Trial name
- NCT03552484
- Testing
- Home Visit Program, Usual Care/Online Survey
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Diabetes Mellitus, Gastroparesis
Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People
The purpose of this study is to determine the effects of the drug lixisenatide on blood sugar levels, stomach emptying, blood pressure and heart rate, release of gut hormones and blood flow in the gut after a glucose drink in…
- Trial name
- Lixi (NCT02308254)
- Testing
- Lixisenatide
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
Cerebral Palsy
ePrime: Evaluation of Magnetic Resonance (MR) Imaging to Predict Neurodevelopmental Impairment in Preterm Infants
Preterm infants face an uncertain future because premature birth often leads to problems with brain development and can cause cerebral palsy.
- Trial name
- ePrime (NCT01049594)
- Where
- 13 sites in United Kingdom
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cerebral Palsy, Chronic Pain
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP.
- Trial name
- NCT05197946
- Testing
- MRI
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Children With Cerebral Palsy
Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL)
During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children.
- Trial name
- VERTEBRAL (NCT06320288)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Cerebral Palsy, Spastic
Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy
Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats.
- Trial name
- INTERACT (NCT06571929)
- Testing
- INTERACT
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Progressive Supranuclear Palsy
Study of Comprehensive ANd Multimodal Marker-based Cohort of Progressive Supranuclear Palsy(PSP)
The purpose of this cohort study is to develop a reliable biomarker in progressive nuclear palsy (PSP).
- Trial name
- SCAN-PSP (NCT05579301)
- Where
- 2 sites in South Korea
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cortical/Cerebral Visual Impairment, Cerebral Palsy
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment
The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment.
- Trial name
- NCT06067607
- Testing
- eye gaze technology
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockhurst University
Bilateral Cerebral Palsy
Horizontal Versus Vertical Upper Extremity Function in Bilateral Cerebral Palsy
The goal of this quasi-experimental study is to investigate and compare the effects of horizontal and vertical upper extremity performance on hand skills and trunk control in children with bilateral spastic cerebral palsy; could…
- Trial name
- NCT07367477
- Testing
- a designed occupational therapy program to improvement hand skills conducted on a vertical surface., a designed occupational therapy (OT) program to improvement hand skills conducted on a horizontal surface.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Raghda Gamal Ateya Abd-Elbary
Cerebral Palsy, Reliability
Turkish Validity And Reliability Of The Hammersmith Infant Neurological Evaluation (Hine)
The high risk of infants are defined as having a negative environmental and biological factor history, where these factors can lead to neuromotor development problems.
- Conditions
- Cerebral Palsy, Reliability, Infant Development, Infant, Premature, Diseases
- Trial name
- Hine (NCT04259177)
- Testing
- Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sanko University
Stroke, Peripheral Neuropathy
Arm Motor Control on Bi and Uni ADLs
This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs.
- Conditions
- Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- BiAs (NCT02778529)
- Testing
- Bilateral assessment robots (BiAS)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cerebral Palsy
Motor Learning in People With Cerebral Palsy by Using Virtual Reality.
Cerebral Palsy (CP) is a group of permanent disorders that affect movement and posture due to a non-progressive lesion in the immature brain occurring in fetal brain development or in infancy.
- Trial name
- NCT03348943
- Testing
- Right hemiparesis, right upper limb., Right hemiparesis, left upper limb, Left hemiparesis, left upper limb
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Gastroparesis
GI-Challenge Study for Gastroparesis Patients and Healthy Controls
Gastroparesis Patients and Healthy Controls ages 20-49 will be asked to participate in an observational study measuring vagal activity following food ingestion in order to establish parameters of autonomic nerve/vagal function in…
- Trial name
- NCT03896126
- Testing
- Observational
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gastroparesis
ABCA2 GIRMS Analytical Validation Clinical Performance Study
The purpose of this study is to collect human breath samples for use in a validation study intended to demonstrate equivalent clinical performance measures of new ABCA2 GIRMS (Automated Breath Carbon Analyzer-2 Gas Isotope Ratio…
- Trial name
- NCT04607304
- Testing
- ABCA2 GIRMS
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics
Chronic Stroke, Cerebral Palsy
Gondola Mechanism of Action
This study will investigate the clinical, functional and neurophysiological effects of automated mechanical peripheral stimulation (AMPS) via the Gondola device administered to patients with chronic stroke, cerebral palsy and…
- Conditions
- Chronic Stroke, Cerebral Palsy, Parkinson's Disease
- Trial name
- NCT05146648
- Testing
- Gondola AMPS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Vestibular Schwannoma
Nimodipine in Vestibular Schwanommas
Title: Intraoperative application of nimodipine to the facial and cochlear nerves during vestibular schwannoma resection to avoid spasm-related postoperative facial paralysis and deafness - a prospective randomized study…
- Trial name
- NCT04801953
- Testing
- NiMODipine Injectable Solution
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cerebral Palsy Infantile
BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone/muscle in Children with Cerebral Palsy
Cerebral palsy (CP) is the most common chronic disability in childhood, burden by motor, sensation, cognition, feeding and communication impairment.
- Trial name
- BIODETECT_CP (NCT06672731)
- Testing
- REMS: Radiofrequency Echographic Multi Spectrometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy
Functional Exercise Training in Cerebral Palsy: Follow Up
The goal of this cross-sectional study is to compare able-bodied peers to adolescents and young adults with cerebral palsy (CP) who have been regularly performing high-intensity functional training for almost two years.
- Trial name
- FITCP (NCT05859360)
- Testing
- Physical performance and cardiovascular health measures
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Basel
Healthy, Spastic Hemiparesis
Soleus Loading Response During Walking
Stroke survivors experience motor deficits, weak voluntary muscle activations, and low weight-bearing capacity that impair ambulation.
- Conditions
- Healthy, Spastic Hemiparesis, Stroke
- Trial name
- NCT05436366
- Testing
- Soleus loading response in able-bodied participants, Soleus loading response in participants with hemiparesis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Victor H. Duenas