Clinical trials: Paraesophageal Hernia, open to volunteers
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Hiatal Hernia, Paraesophageal, Hiatal Hernia Large
Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.
This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease.
- Conditions
- Hiatal Hernia, Paraesophageal, Hiatal Hernia Large, Hiatal Hernia With Gastroesophageal Reflux Disease
- Trial name
- NCT07718828
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Sofia Med Hospital
Paraesophageal Hernia, Large Hiatal Hernia
Ovitex in Paraesophageal and Large Hiatal Hernia Repair
The purpose of the study is to evaluate the success of hiatal hernia repairs in patients with large (>5cm) or paraesophageal hernias when Ovitex LPR mesh used during the repair.
- Trial name
- OviPHeR (NCT06193551)
- Testing
- Ovitex LPR
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Foregut Research Foundation
Paraesophageal Hernia
Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair
This study will be a prospective observation study of the use of PoRSHA for repair in patients with challenging paraesophageal hernias.
- Trial name
- NCT06551077
- Testing
- POSTERIOR RECTUS SHEATH HIATAL AUGMENTATION (PORSHA)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Paraesophageal Hernia, GERD
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at…
- Trial name
- NCT05974722
- Testing
- OviTex Mesh, Pledgeted sutures
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- David Krpata
Paraesophageal Hernia
Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair
Paraesophageal hernia can cause significant clinical symptoms, including reflux, chest pain, nausea, regurgitation, and even life threatening conditions such as bowel obstruction, and gastric volvulus.
- Trial name
- NCT07197619
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Corewell Health West
Hiatal Hernia, Paraesophageal Hernia
Nissen Versus Dor Hiatal Hernia Repair
Hiatal hernia can present with a wide range of symptoms. An usual surgical repair technique usually includes Nissen fundoplication, while other procedures are less frequently employed.
- Conditions
- Hiatal Hernia, Paraesophageal Hernia, Recurrence
- Trial name
- NiDor (NCT06725433)
- Testing
- Nissen fundoplication, Dor fundoplication
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Kuopio University Hospital
Paraesophageal Hernia
Gastropexy in the Repair of Patients with Paraesophageal Hernias
Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional surgical hernia repair or with the addition of gastropexy.
- Trial name
- PEH3 (NCT06107634)
- Testing
- Gastropexy, Paraesophageal hernia repair
- Where
- 6 sites in Sweden
- Volunteers
- 124 people
- Sponsor
- Ersta Diakoni
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Paraesophageal Hernia
Gastropexy as a Treatment Option for Paraesophageal Hernia
The present proposal aims to asses which is the optimal treatment strategy in a clinical study in patients with paraoesophageal hernia (PEH), a condition often found in elderly, fragile patients The investigator want to study the…
- Trial name
- NCT06096402
- Testing
- no intervention, but surgical practice as usual is continued. Its a pragmatic study
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 220 people
- Sponsor
- University Hospital of North Norway
Paraesophageal Hernia, Hiatal Hernia
Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair
Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux…
- Conditions
- Paraesophageal Hernia, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Recurrence
- Trial name
- NCT05201508
- Testing
- Polyglactin mesh, Sutures only
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Oulu University Hospital