Clinical trials: Pancreatitis, Acute, open to volunteers
Familial Chylomicronemia Syndrome (FCS)
CS-121 APOC3 Base Editing in FCS
This is an open-label, single-arm, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid…
- Trial name
- NCT07176923
- Testing
- CS-121
- Where
- China
- Volunteers
- 15 people
- Sponsor
- CorrectSequence Therapeutics Co., Ltd
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre
Acute Pancreatitis
Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics
The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop…
- Trial name
- DREAM-ON (NCT06401577)
- Testing
- Dexcom Continuous Glucose Monitor (CGM)
- Where
- 13 sites in United States
- Volunteers
- 800 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Necrotizing Pancreatitis, Infected Pancreatic Necrosis
Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing Pancreatitis
This study is being done to find a faster and more accurate way to tell whether the necrosis in patients with acute necrotizing pancreatitis (ANP) has become infected.
- Trial name
- PROMOTE (NCT07308600)
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis
GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis
Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is associated with a high risk of recurrence despite standard lipid-lowering therapy and lifestyle modification.
- Conditions
- Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis, Pancreatitis Relapsing, Hypertriglyceridemia
- Trial name
- RECAP-GLP1 (NCT07617155)
- Testing
- Semaglutide
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Peking Union Medical College Hospital
Acute Pancreatitis Due to Gallstones
Ursodeoxycolic Acid for the Prevention of Relapsing Complications After Gallstone Acute Pancreatitis
Acute pancreatitis is a common disease (3rd cause of hospital admission for digestive causes), which is associated with significant patient suffering, a 2-4% probability of death and considerable healthcare costs.
- Trial name
- OSOPOLAR (NCT04924868)
- Testing
- Ursodeoxycholic Acid
- Where
- 18 sites in Spain
- Volunteers
- 332 people
- Sponsor
- Hospital General Universitario de Alicante
Organ Dysfunction, Organ Support
Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction
Acute pancreatitis may cause early respiratory, cardiovascular, or renal dysfunction and may require intensive care and organ support.
- Conditions
- Organ Dysfunction, Organ Support, Acute Pancreatitis (AP)
- Trial name
- TEA-APOD (NCT07697690)
- Testing
- Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia
- Volunteers
- 150 people
- Sponsor
- First People's Hospital of Chenzhou
Acute Pancreatitis (AP), Thrombotic Disorders
Retrospective Analysis of Acute Pancreatitis After Percutaneous Mechanical Thrombectomy In Treatment Of Thrombotic Disorders
Acute pancreatitis is a rare complication after percutaneous mechanical thrombectomy in treatment of thrombotic disorders. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after…
- Trial name
- NCT07450898
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Islet Cell Tumor, Pancreatic Cancer
Collecting Medical Information and Tissue Samples From Patients With Pancreatic Cancer or Other Pancreatic Disorders
RATIONALE: Gathering medical information and collecting and storing samples of blood and tissue to test in the laboratory may help doctors develop better ways to screen people at risk for pancreatic cancer or other pancreatic…
- Conditions
- Islet Cell Tumor, Pancreatic Cancer, Pancreatic Disease, Acute Pancreatitis
- Trial name
- NCT00830557
- Testing
- medical chart review, survey administration, biospecimen collection
- Where
- 3 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Mayo Clinic
Acute Pancreatitis
Study of SGC001 Injection for Predicted Severe Acute Pancreatitis to Assess Safety, Tolerability and Preliminary Efficacy
This is an early phase clinical study. Patients who are at high risk of developing severe acute pancreatitis will be screened. Participants will be randomly assigned to receive either SGC001 injection or a placebo injection that…
- Trial name
- NCT07803965
- Testing
- SGC001 injection
- Where
- 15 sites in China
- Volunteers
- 129 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
Hypertriglyceridemia Induced Acute Pancreatitis
Adding Evolocumab to Conventional Lipid-lowering Therapy for Hypertriglyceridemia Induced Acute Pancreatitis
The severity of hypertriglyceridemia induced acute pancreatitis (HTG-AP) is closely related to the serum triglyceride (TG) levels. The higher the TG levels, the greater the risk of developing severe acute pancreatitis (SAP).
- Trial name
- NCT07388420
- Testing
- Evolocumab 140 MG/ML [Repatha], Conventional lipid-lowering therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Shenyang Military Region
Acute Pancreatitis (AP), Acute Pancreatitis With Infected Necrosis
Comparison of MIPPED-C and Surgical Necrosectomy in Pancreatic Necrosis Outcomes
This study is a retrospective, single-center, pre-post controlled clinical study. Patients (n=48) who underwent the MIPPED-C surgical procedure after January 1, 2019 were designated as the treatment group.
- Trial name
- NCT07097753
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Ruijin Hospital
Pancreatitis, Pancreatitis, Acute
Intermittent Fasting for Pancreatitis
The purpose of this research is to compare intermittent fasting with a standard diet approach for improving the quality of life related to your pancreas disease.
- Conditions
- Pancreatitis, Pancreatitis, Acute, Pancreatitis, Chronic, Pancreas Disease
- Trial name
- IFPanc (NCT04760847)
- Testing
- Intermittent Fasting, No intermittent fasting
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Acute Necrotizing Pancreatitis
Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
This is a national single-blinded prospective multicenter randomized (1:1) controlled trial, with two parallel arms, using a PROBE methodology, including patients with complicated acute necrotizing pancreatitis who require DEN of…
- Trial name
- ROTONEC (NCT07253350)
- Testing
- Endorotor Group, Conventional group
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis (AP)
Stroke Volume-based Fluid Resuscitation in AP
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients.
- Trial name
- SUSTAIN (NCT07756476)
- Testing
- Lactated Ringer's, Lactated Ringers Stroke Volume Based Dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Southern California
Pancreatic Diseases
PAncreatic Disease Cohort of TOuLouse
This study is a prospective cohort dedicated to pancreatic diseases excluding cancer. The aim is to develop positive or differential diagnostic tools between benign potentially malignant or malignant pancreatic pathologies.
- Trial name
- PACTOL (NCT05824403)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Pancreatitis, Chronic Pancreatitis
Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain
Severe and disabling abdominal pain is common in individuals with chronic pancreatitis. Although pain is associated with reduced quality of life and high economic and societal costs, there are limited effective options for pain…
- Conditions
- Pancreatitis, Chronic Pancreatitis, Acute Recurrent Pancreatitis
- Trial name
- IMPACT-2 (NCT06386224)
- Testing
- Internet-delivered pain self-management (CBT Condition), Education Program
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Seattle Children's Hospital
Pancreatitis Biliary, Pancreatitis Acute Biliary
Indomethacin for Biliary ERCP Patients
This study is a randomized clinical trial evaluating the efficacy of rectal indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in patients undergoing biliary ERCP who have a history…
- Conditions
- Pancreatitis Biliary, Pancreatitis Acute Biliary, Pancreatitis, Post-ERCP Pancreatitis
- Trial name
- NCT07661498
- Testing
- indomethacin
- Where
- United States
- Volunteers
- 860 people
- Sponsor
- University of California, San Francisco
Acute Pancreatitis (AP), Severe Acute Pancreatitis
Bowel Sound in Predicting the Severity of Acute Pancreatitis: Protocol of a Prospective, Multi-center Study
Introduction: Acute pancreatitis (AP) is a common condition, with 20% of cases progressing to severe acute pancreatitis (SAP), which is associated with a poor prognosis.
- Trial name
- NCT06867120
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Peking Union Medical College Hospital