Clinical trials: Pancreatic Necrosis
Pancreatitis,Acute Necrotizing
Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis
This is a randomized trial comparing immediate endoscopic necrosectomy vs. step-up endoscopic interventions in patients with necrotizing pancreatitis.
- Trial name
- DESTIN (NCT05043415)
- Testing
- Immediate endoscopic necrosectomy, Step-up endoscopic interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Orlando Health, Inc.
Acute Necrotizing Pancreatitis, Portosplenomesenteric Venous Thrombosis
Acute Pancreatitis and Thrombosis (PATHRO)
Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of…
- Trial name
- PATHRO (NCT04642794)
- Testing
- observational study
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Nantes University Hospital
Acute Necrotizing Pancreatitis
Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis
Acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (IPN). IPN usually occurs after the first week of evolution.
- Trial name
- PANIC (NCT03234166)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Acute Pancreatitis, Necrosis; Pancreas, Acute (Infectious)
Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis
In acute pancreatitis, approximately 20% of the cases result in severe necrotizing pancreatitis which is associated with significant morbidity and mortality.
- Trial name
- RESOlVE (NCT04814693)
- Testing
- EndoRotor® System (Interscope, Inc., Northbridge, MA USA),, Conventional endoscopic devices (according to standards of care)
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Pancreatic Pseudocyst
Endoscopic Ultrasound-guided Drainage of Walled Off Necrosis (WON)
The purpose of this study is to compare the effect of lumen-apposing metal stent (LAMS) and double pigtail plastic stents (DPPSs) on the drainage of pancreatic walled-off necrosis (WON), mainly to observe the efficacy and safety…
- Trial name
- NCT03027895
- Testing
- Lumen-apposing metal stent (LAMS), Double pigtail plastic stent (DPPS)
- Volunteers
- 256 people
- Sponsor
- Yiqi Du
Pancreatic Pseudocyst, Pancreatic Necrosis
EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent
To evaluate clinical efficacy and safety of a novel lumen-apposing FCSEMS for EUS-guided transenteric drainage of PFC or of biliary tree including GB
- Conditions
- Pancreatic Pseudocyst, Pancreatic Necrosis, Biliary Obstruction, Acute Cholecystitis
- Trial name
- NCT03002051
- Testing
- EUS-guided drainage
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Chinese University of Hong Kong
Pancreatitis, Pancreatitis, Acute Necrotizing
Etiology, Clinical Picture, Complications and Outcomes of Necrotizing Pancreatitis in Children.
The aim of this research is to study the etiology, the clinical picture, the management, the complications and the outcomes of necrotic pancreatitis in children.
- Conditions
- Pancreatitis, Pancreatitis, Acute Necrotizing, Children
- Trial name
- NCT06700330
- Testing
- no intervention, observational study
- Where
- Russia
- Volunteers
- 102 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Acute Pancreatitis
Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Around 20 per cent of patients with acute pancreatitis develop pancreatic or peripancreatic necrosis with or without peripancreatic collection.
- Trial name
- NCT01977118
- Testing
- streptokinase, Saline irrigation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Necrotizing Pancreatitis, Infection
PancRea: Risk Factors and Outcomes of Infected Pancreatic Necrosis
Severe acute pancreatitis is a common reason for intensive care unit (ICU) admission and is associated with prolonged hospital stays and high morbidity and mortality rates.
- Conditions
- Acute Necrotizing Pancreatitis, Infection, Pancreatitis
- Trial name
- PancRea (NCT03253861)
- Testing
- No intervention
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Nantes University Hospital
Necrotizing Pancreatitis
Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
- Trial name
- NCT07201246
- Testing
- Necrotizing Pancreatitis patients' organdysfunction progression
- Where
- China
- Volunteers
- 700 people
- Sponsor
- West China Hospital
Pancreatitis, Acute Necrotizing, Walled Off Necrosis
Lumen-apposing Metal Stent With or Without Coaxial Plastic Stent for Treatment of Walled-off Pancreatic Necrosis
A prospective randomized cohort study to compare whether the placement of a double-pigtail plastic stent (DPS) within a lumen-apposing metal stent (LAMS) may improve the efficacy and safety of endoscopic ultrasound guided…
- Trial name
- NCT03923686
- Testing
- EUS-guided drainage using LAMS with DPS, EUS-guided drainage using LAMS alone
- Where
- Czechia
- Volunteers
- 67 people
- Sponsor
- Palacky University
Acute Necrotizing Pancreatitis
Early Enteral Nutrition for Severe Acute Pancreatitis
There is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients.
- Trial name
- NCT00995098
- Testing
- early enteral nutrition, Parenteral nutrition
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Academy of Medical Sciences
Acute Necrotizing Pancreatitis
Prophylactic Pancreatic Duct Stenting in Acute Necrotizing Pancreatitis
Since the majority of patients with necrotizing pancreatitis will experience a leak from the pancreatic duct during their course of disease resulting in intra- and peripancreatic fluid collections, it is reasonable to hypothesize…
- Trial name
- ERPNEC (NCT01767233)
- Testing
- ERCP and pancreatic stenting
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- University of Oulu
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari
Necrotizing Pancreatitis
Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy
The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
- Trial name
- NCT06380842
- Testing
- Necrotizing Pancreatitis patients' organ dysfunction progression
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chunling Jiang
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Acute Pancreatitis
Late Phase Acute Pancreatitis: a Tailored Step-up Approach
Several interventional and surgical procedures are available to treat moderate-to-critical acute pancreatitis (AP) in its late phase.
- Trial name
- TSA (NCT04870268)
- Testing
- percutaneous drainage, endoscopic approach, surgical internal derivation of WON
- Volunteers
- 47 people
- Sponsor
- University of Pisa
Children, Pancreatic Fistula
The Study of the Natural Way of Development of External Pancreatic Fistulas in Children with Necrotizing Pancreatitis
The external pancreatic fistula (EPF) is characterized by the leakage of pancreatic juice outward through an area of skinor through a drainage tube.
- Conditions
- Children, Pancreatic Fistula, Pancreatitis,Acute Necrotizing, Pancreatitis, Acute
- Trial name
- NCT06706440
- Testing
- no intervention, observational study
- Where
- Russia
- Volunteers
- 26 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Colorectal Cancer, Locally Advanced
QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors
This is a multi-center, 2-part phase 1b/2 study of AMG 655 in combination with AMG 479 to be conducted in the United States and Spain.
- Conditions
- Colorectal Cancer, Locally Advanced, Metastatic Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT00819169
- Testing
- AMG 479, AMG 655
- Volunteers
- 89 people
- Sponsor
- NantCell, Inc.
Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP)
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis
The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis.
- Conditions
- Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP), Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT07395778
- Testing
- endoscopic ultrasonography guided cystogastrostomy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh