Clinical trials: Palliative Therapy
Oncology
Impact of Acupuncture and Manual Therapies on Patients' Quality-of-life in a Hospital-to-community Continuum
Oncology patients often suffer during hospitalization from pain, emotional distress, gastrointestinal symptoms, weakness, and quality of life (QoL)-related concerns.
- Trial name
- NCT06590766
- Testing
- acupressure/relaxation with acupuncture
- Where
- Israel
- Volunteers
- 520 people
- Sponsor
- Carmel Medical Center
Dyspnea
Palliative Oxygen for the Relief of Breathlessness
The main goal of this study is to establish the effectiveness of palliative oxygen in the context within which it is usually provided--relief of the sensation of breathlessness and improvement in quality of life for people with…
- Trial name
- NCT00327873
- Testing
- Oxygen, Medical Air
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 240 people
- Sponsor
- National Health and Medical Research Council, Australia
Breast Cancer
Effects of an ICT-platform for Assessment and Management of Patient-reported Symptoms During Treatment for Breast Cancer
The purpose of this study is to evaluate the effects of an interactive Information and Communication Technologies (ICT) -platform for use in a smartphone or tablet in patients treated with neoadjuvant chemotherapy for breast…
- Trial name
- PhONEME (NCT02479607)
- Testing
- Smartphone or tablet
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Colorectal Cancer, Bladder Cancer
Effects of a Neuroscience-based Technique on Cancer Patients Announced of a Palliative Disease Progression and Partners
The diagnosis and treatment trajectory of cancer can constitute a traumatic event because these can be perceived as sudden, catastrophic and life threatening.
- Conditions
- Colorectal Cancer, Bladder Cancer, Prostate Cancer, Kidney Cancer
- Trial name
- NeuroPrevPTSD (NCT03652298)
- Testing
- Memory structuring intervention + Vagal breathing, support and attention (usual care)
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Oscar Lambret
MDS, AML, Adult
Quality of Life-Guided Transfusion in Refractory MDS or AML
Patients with refractory myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) in exclusive palliative care frequently receive red blood cell transfusions based on hemoglobin thresholds, despite limited evidence of…
- Conditions
- MDS, AML, Adult, Anemia
- Trial name
- Q-TRANS (NCT07328191)
- Testing
- Red blood cell transfusions based on EQ-5D-5L questionnaire
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Palliative Care
Randomized Controlled Trial of Group Psychotherapy Interventions for Cancer Patients
The purpose of this study is to compare two types of group counseling for cancer patients: Meaning-Centered counseling and Supportive counseling.
- Trial name
- NCT00494910
- Testing
- Meaning Centered Group Psychotherapy, Supportive Group Psychotherapy
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Cancer
Behavioral Nudges to Improve Palliative Care Utilization in Advanced Cancer
Patients with cancer often undergo costly therapy and acute care utilization that is discordant with their wishes, particularly at the end of life.
- Trial name
- BE-EPiC (NCT05365997)
- Testing
- Default Nudge
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Patients With Symptomatic or Bulky Tumors (More Than 8 cm) or With Tumors Resistant to Radiation
GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors
Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumors, radiotherapy schema varies from 24 to 30 Gys…
- Trial name
- NCT02333110
- Testing
- spatially fractionated radiation therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Advanced Dementia Stages, Palliative Care
IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany
From a scientific view, palliative care issues in dementia are neglected in Germany. Neither in Germany nor internationally research has been conducted on palliative care issues in young onset dementia (YOD), although significant…
- Trial name
- EPYLOGE (NCT03364179)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Informal Caregiver
The Effect of Mindfulness-Based Compassionate Living Training Given to Caregivers of Inpatients in Palliative Clinic
In this study, it was aimed to determine the effect of "Mindfulness-Based Compassionate Life Training" given to the relatives of patients in the palliative care clinic on burnout and care burden.
- Trial name
- Mindfulness (NCT05886959)
- Testing
- Session 1: How We Evolved - Threat, Impulse, and Soothing Systems, Session 2: Threat and Self-Compassion, Session 3: Unraveling the Knots of Desire and Patterns
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Depression, Cancer
Study of Ketamine for Depression in Cancer Patients Receiving Palliative Care
This is a phase 2 study of the drug ketamine for the treatment of depression in cancer patients receiving palliative care. The purpose of this study is to see how useful the drug is at decreasing the severity of depression these…
- Conditions
- Depression, Cancer, Palliative Care
- Trial name
- NCT03410446
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Symptom Management, Reduce Treatment Non-adherence
Project Persist: mHealth for Cancer Survivorship
Many studies have shown that anxiety and depression are associated with reduced treatment adherence and poor treatment outcomes among patients undergoing cancer treatments.
- Trial name
- Persist (NCT04126642)
- Testing
- Assessment only group, Intervention group
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Oklahoma
Chronic Hepatitis B, Hepatocellular Carcinoma
Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common solid cancers worldwide, and chronic hepatitis B virus (HBV) infection is the most common etiology of HCC in Asia.
- Trial name
- NCT01872988
- Testing
- Tenofovir
- Where
- 4 sites in Taiwan
- Volunteers
- 320 people
- Sponsor
- Taichung Veterans General Hospital
Pancreatic Cancer
EUS Guided Neurolysis Celiac Block w/wo Bupivacaine in Patient Being Treated Palliatively for Pancreatic Cancer
The goal of this project is to determine if EUS-CPN without Bupivacaine (versus EUS-CPN with Bupivacaine) can reduce pain scores and improve quality of life in patients with inoperable pancreatic cancer by reducing the morbidity…
- Trial name
- EUS-CPN (NCT02682082)
- Testing
- Endoscopic ultrasound-guided celiax plexus neurolysis, Bupivacaine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sarcoma
NY-ESO-1-Specific T-cells in Treating Patients With Advanced NY-ESO-1-Expressing Sarcomas Receiving Palliative Radiation Therapy
This pilot, phase I trial studies the safety of cancer-testis antigen (NY-ESO-1)-specific T cells (a type of immune cell) in treating patients with NY-ESO-1-expressing sarcomas that have spread to other places in the body and are…
- Trial name
- NCT02319824
- Testing
- Autologous NY-ESO-1-specific CD8-positive T Lymphocytes, Laboratory Biomarker Analysis, Palliative Radiation Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer
The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer
Metastatic breast cancer patients with bone involvement who are at high-risk of subsequent skeletal related event (SRE), defined as radiotherapy or surgery to the bone, pathological fracture, spinal cord compression, or…
- Trial name
- ER11-03 (NCT01907880)
- Testing
- Pamidronate, Zoledronic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- Ottawa Hospital Research Institute
Rectal Cancer, Quality of Life
Quality of Life in RECTal Cancer - a Prospective Multicenter Cohort Study
Rectal cancer is a common type of cancer occuring more frequently in men but also common in women. Almost 60% of the patients survive 5-years and the treatment has been continuously developed in the last three decades.
- Conditions
- Rectal Cancer, Quality of Life, Surgery
- Trial name
- QoLiRECT (NCT01477229)
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Cancer
Does Acupressure Help Reduce Nausea and Vomiting in Palliative Care Patients?
Randomised controlled trial of acupressure wrist bands for hospice in-patients suffering from terminal cancer who are troubled by nausea and vomiting.
- Trial name
- NCT00220688
- Testing
- Acupressure Wristbands
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Deprescribing, Palliative Care
DEprescribing: Perceptions of PAtients Living With Advanced Cancer
Polymedication in palliative oncology care is a real public health problem. This phenomenon has been shown to increase the risk of iatrogenesis, reduce patients' quality of life and increase healthcare costs.
- Conditions
- Deprescribing, Palliative Care, Oncology
- Trial name
- DEPAL (NCT06193083)
- Testing
- Semi-directed individual interviews, The self-administered questionnaires, rPATD and BMQ, The self-administered FCCHL (Functional, Communicative and Critical Health Literacy) / HLS14 (14-item health literacy scale)
- Where
- 8 sites in France
- Volunteers
- 325 people
- Sponsor
- Nantes University Hospital