Clinical trials: Palliative Therapy
Head and Neck Carcinoma, Localized Head and Neck Carcinoma
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)
This trial tests how well personalized ultra fractionated stereotactic adaptive radiotherapy (PULSAR) works together with HyperArc© radiation treatment planning technology for palliative (holistic pain and symptom control) tumor…
- Conditions
- Head and Neck Carcinoma, Localized Head and Neck Carcinoma, Metastatic Head and Neck Carcinoma, Recurrent Head and Neck Carcinoma
- Trial name
- PULS-Pal (NCT06572423)
- Testing
- Personalized ultrafractionated stereotactic adaptive radiotherapy, Volume Modulated Arc Therapy, Computed Tomography
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Bone Metastases
Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009
Cancer patients with pain due to bone metastases are often treated with external irradiation in order to reduce pain. However, patients may experience a temporary increase of pain shortly after irradiation, a so-called pain…
- Trial name
- NCT01669499
- Testing
- Dexamethasone acetate
- Where
- 2 sites in Netherlands
- Volunteers
- 411 people
- Sponsor
- UMC Utrecht
Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck
Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer
Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's…
- Trial name
- QSSC-HN (NCT07823309)
- Testing
- Quad Shot Radiotherapy, Split Course Radiotherapy
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
COPD
Palliative Care Health Literacy Education and QOL Compared to Usual Care
The goal of this pilot randomized controlled trial is to compare health literacy (HL) and quality of life (QOL) among older adults with chronic obstructive pulmonary disease (COPD) who completed a series of standardized…
- Trial name
- PACED (NCT06089499)
- Testing
- Get Palliative Care: four educational learning module videos
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Palliative Care, Micronutrients
Micronutrient Status in Pediatric Palliative Care
The goal of this observational study is to determine the micronutrient levels in patients in the Pediatric Palliative Care Clinic.
- Conditions
- Palliative Care, Micronutrients, Pediatric
- Trial name
- NCT06146452
- Testing
- Not
- Where
- Turkey (Türkiye)
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Dr. Behcet Uz Children's Hospital
Burnout Syndrome
Burnout Syndrome in the Intensive Care Unit Before and During a Palliative Care Trial
One hundred ICU doctors, nurses and psychologists from 4 / 8 ICUs of the Greek group of the 28 European units participating in the EPIC stepped-wedge trial (ClinicalTrials.gov NCT06605079) will each complete the same four-part…
- Trial name
- BURNOUT-EPIC (NCT07069010)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Palliative Care, Intensive Care Unit
Critical Care and Palliative Care Medicine Together in the ICU
Will earlier palliative care medicine consultation in the ICU result in decreased length of stay in the ICU and hospital, as well as, increased patient and family satisfaction.
- Conditions
- Palliative Care, Intensive Care Unit, Hospice
- Trial name
- NCT03520023
- Testing
- Palliative Care Consult
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Mayo Clinic
Cancer, Radiotherapy
Prognosis of Patient Evaluated for Palliative Radiotherapy
Many patients with incurable cancer will receive palliative oncological treatment before their death, and radiotherapy (RT) is an important element of this.
- Trial name
- PROPER (NCT03797755)
- Testing
- palliative radiotherapy
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Tuen Mun Hospital
Terminal Illness, End of Life
Elaboration of a Multi-dimensional Indicator of Quality in Palliative Care
The purpose of this study is to elaborate a multi-dimensional indicator of the quality in palliative care for patients of end-of-life.
- Trial name
- QUALI-PALLI (NCT02814682)
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain
Investigation of Cannabis for Chronic Pain and Palliative Care
The use of cannabis for severe medical conditions is being legalized in different states, increasing the mandate to make cannabis legal for medically ill patients.
- Trial name
- NCT02683018
- Testing
- Smoked Cannabis High CBD/low THC
- Sponsor
- New York State Psychiatric Institute
Head and Neck Squamous Cell Carcinoma
3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial
To learn if it is effective to use advanced radiation treatment techniques (stereotactic radiation or "SBRT") to safely deliver a strong dose of radiation to your tumor in a shorter period of time than would typically be feasible…
- Trial name
- NCT05674396
- Testing
- Stereotactic body radiotherapy, Traditional Palliation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- M.D. Anderson Cancer Center
Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas
Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction
A randomised clinical trial to compare the clinical efficacy of multiple plastic stents to fully covered self expanding metal stents in the palliation of distal malignant biliary obstruction in patients with irresectable tumours.
- Conditions
- Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas, Cancer of the Bile Duct, Biliary Stricture
- Trial name
- NCT03821025
- Testing
- Biliary stent
- Where
- South Africa
- Volunteers
- 150 people
- Sponsor
- University of Cape Town
Cancer (Active Cancer, Meaning Not Being Cancer Free), of Any Stage and Involving Any Treatment/Care Regimen; i.e. Curative, Life-extending, or Palliative
International Study to Evaluate a Navigation Program for Older People With Cancer and Their Family Caregivers (EU NAVIGATE Study)
Most people with cancer are older, and this affects millions of Europeans yearly. Integrating high-quality, equitable, and cost-effective care across the continuum of supportive, palliative, and end-of-life care for both patients…
- Trial name
- EU NAVIGATE (NCT06110312)
- Testing
- NavCare-EU
- Volunteers
- 489 people
- Sponsor
- Vrije Universiteit Brussel
Acute Myeloid Leukemia
Investigating Integrative Therapies for Symptom Management in Adults With Acute Leukemia
This pilot study will use a mixed methods approach to evaluate the feasibility and acceptability of Integrative Therapies, a bedside service offering mindfulness-based interventions (still meditation, meditative movement…
- Trial name
- NCT04185428
- Testing
- Integrative Therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Non-Small Cell Lung Cancer (NSCLC)
Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung Cancer
This is a dose escalation study that will assess the safety of Vorinostat, a Histone Deacetylase (HDAC) inhibitor, in combination with palliative radiotherapy in patients with advanced or metastatic Non-Small Cell Lung Cancer…
- Trial name
- NCT00821951
- Testing
- Vorinostat, Radiotherapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Palliative Care, Primary Health Care
PROject - Supportive and Palliative Care and INnOvation - Antwerp (Pro-Spinoza)
It is important to provide high quality palliative care to all patients with a non-curable and life-limiting condition. The Care Pathway for Primary Palliative Care (CPPPC) provides tools for health care professionals to help…
- Trial name
- pro-Spinoza (NCT02266069)
- Testing
- Care Pathway for Primary Palliative Care
- Where
- 4 sites in Belgium
- Volunteers
- 24 people
- Sponsor
- Bert Leysen
Lung Cancer
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment
This study will compare the effects of a brief supportive intervention, called Pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advanced lung cancer.
- Trial name
- NCT06047301
- Testing
- Pathways, Enhanced Usual Care
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Laurie McLouth
Palliative Care, Deep Sedations
Prevalence of Deep Sedation in Terminal Palliative Phase
This nation-wide, multicentric, prospective and cross-sectional study aims to estimate the prevalence of deep sedations (i.e. with a -4 or -5 score at the Richmond scale at the induction time) for patients in terminal phase and…
- Trial name
- PREVAL-S2P (NCT04333719)
- Testing
- Type of sedations
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma
Registry Platform Gastric/Esophageal Cancer (SAPHIR)
The registry aims to collect and analyse information on the antineoplastic treatment of patients with metastatic esophageal, gastric or gastroesophageal junction cancer, treated in palliative intention in daily routine practice…
- Conditions
- Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma
- Trial name
- SAPHIR (NCT04290806)
- Testing
- Routine care as per site standard
- Where
- Germany
- Volunteers
- 1,900 people
- Sponsor
- iOMEDICO AG
Palliative Care
Conversational Agents to Improve Quality of Life in Palliative Care
In this study the investigators will advance research on the development of easy to use technologies to empower patients. This is a scalable approach that has a significant potential to reduce suffering for palliative care…
- Trial name
- ECA-PAL (NCT02750865)
- Testing
- Embodied Conversational Agent (ECA)
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Boston Medical Center