Clinical trials: Painful Peripheral Neuropathy, open to volunteers
Multiple Sclerosis, Neuropathic Pain
OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis
This is an early phase safety evaluation of the use of oral extended release (OER) glibenclamide, which is otherwise known as glyburide, for use as a treatment for neurologic pain in people with multiple sclerosis.
- Trial name
- NCT07221799
- Testing
- glibenclamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy
The research team will perform a comparative-effectiveness sequential, multiple assignment, randomized trial in painful diabetic neuropathy (PDN) patients for 8 total months, divided into two 4-month stages.
- Trial name
- MCPAIN (NCT07795593)
- Testing
- Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication
- Where
- 23 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Cryo Analgesia, Pectus Surgery
Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis
Follow up of patients who underwent percutaneous cryoneurolysis for pectus excavatum repair (the Nuss procedure) pain management
- Trial name
- CRYOFUP (NCT07657845)
- Testing
- Self-report Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Questionnaire - Pediatric Quality of Life Inventory (PedsQL™) Questionnaire - Patient Self-Assessment Sensory Scale
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Papa Giovanni XXIII Hospital
Low Back Pain, Neck Pain
Applying Artificial Intelligence in Developing Personalized and Sustainable Healthcare for Spinal Disorders
The primary objective is to use machine learning methods on large survey and health register data to identify participants with different treatment trajectories and health outcomes after surgical and/or conservative treatment for…
- Conditions
- Low Back Pain, Neck Pain, Disc Herniation, Disc Degeneration
- Trial name
- AID-Spine (NCT05745129)
- Where
- Norway
- Volunteers
- 165,000 people
- Sponsor
- Oslo Metropolitan University
Trigeminal Neuralgia
Comparison of Pulsed and Thermal Radiofrequency for Trigeminal Neuralgia
The goal of this clinical trial is to compare the effectiveness of Pulsed Radiofrequency (PRF) with Pulsed and Thermal Radiofrequency (PRF + TRF) in treating Trigeminal Neuralgia (TN) in adults.
- Trial name
- NCT06684275
- Testing
- Pulsed Radiofrequency (PRF), Pulsed and Thermal Radiofrequency (PRF + TRF)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Nerve Pain
Ultrasound Guided Radiofrequency Ablation of the Occipital Nerve
Study an ultrasound guided approach to radiofrequency ablation of the occipital nerve that makes it possible to see the needle during treatment procedure.
- Trial name
- NCT06583122
- Testing
- Ultrasound Guided Approach
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Lumbar Spinal Stenosis, Lumbar Radiculopathy
Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression
Lumbar spinal surgery is common, and the incidence of spinal fusion has increased dramatically over the past three decades. Patients requiring spinal surgery are typically prescribed several analgesics, (including opioids) while…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Radiculopathy, Persistent Postsurgical Pain
- Trial name
- Lumbar-ESP (NCT06987409)
- Testing
- Continuous erector spinae plane block
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Frozen Shoulder, Adhesive Capsulitis
USG-Guided Shoulder Injections in Frozen Shoulder
Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, Nociplastic Pain
- Trial name
- NCT07493213
- Testing
- USG-guided suprascapular nerve block, USG-Guided suprascapular nerve block plus subacromial injection.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Complex Regional Pain Syndromes
Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial
Complex Regional Pain Syndrome (CRPS) is a debilitating pain condition that usually develops following trauma. Patients with CRPS experience intense, continuing, disproportionate pain and multiple symptoms such as changes or…
- Trial name
- Bath-Min (NCT07818174)
- Testing
- Graded Motor Imagery + Therapeutic exercises
- Where
- 20 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Degenerative Lumbar Spinal Stenosis
Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis
The purpose of this study is to compare two different surgical techniques for treating degenerative lumbar canal stenosis, a condition where the lower spinal canal narrows and puts pressure on the spinal nerves.
- Trial name
- NCT07542054
- Testing
- Segmental Decompression, Wide Decompression with Fixation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Pain Measurement, Chronic Pain
Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System
Chronic postsurgical pain (CPSP) remains a significant clinical and public health challenge despite major advances in surgical and anesthetic techniques.
- Conditions
- Pain Measurement, Chronic Pain, Cardiac Implantable Electrical Devices, Neuropathic Pain
- Trial name
- PAIN-AID (NCT07322900)
- Volunteers
- 180 people
- Sponsor
- Istanbul University - Cerrahpasa
Knee Osteoarthritis, Sleep Disturbance
Neuropathic Pain and it's Relation to Sleep Quality in Knee Osteoarthritis
The primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. For this purpose a progressive longitudinal study design was planned.
- Conditions
- Knee Osteoarthritis, Sleep Disturbance, Neuropathic Pain
- Trial name
- NCT06430918
- Testing
- physical examination, questionnaires and inventories
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bozyaka Training and Research Hospital
Knee Osteoarthristis
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability.
- Trial name
- NCT07367126
- Testing
- Clinical and Functional Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Radiculopathy
Interest of the Virtual Reality as an Analgesic Support and in the Management the Pre-procedural Anxiety in Rheumatology
As a part of the current rheumatological practice skills, epidural injections through the sacrococcygeal hiatus take part in the strategy for managing radicular diseases.
- Trial name
- REAVIR (NCT05289999)
- Testing
- Virtual reality headset for first injection, Virtual reality headset for second injection
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier le Mans
Lumbar Disc Disease, Low Back Pain
Clinical and MRI Findings in Lumbar Disc Disease
Low back pain related to lumbar disc disease is a very common condition. Doctors frequently use Magnetic Resonance Imaging (MRI) to look at the spine and diagnose these problems.
- Conditions
- Lumbar Disc Disease, Low Back Pain, Lumbar Disc Herniation, Lumbosacral Radiculopathy
- Trial name
- NCT07516613
- Volunteers
- 96 people
- Sponsor
- Assiut University
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Postoperative Pain, Pain Management
Comparison of Two Postoperative Care Strategies After Breast Surgery
The goal of this clinical trial is to compare two postoperative analgesia strategies in adult women undergoing breast surgery and to evaluate their effects on postoperative pain and quality of recovery after hospital discharge.
- Conditions
- Postoperative Pain, Pain Management, Breast Surgery, Chronic Postoperative Pain
- Trial name
- NCT07880223
- Testing
- Patient Education, Paracetamol, Dexketoprofen
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Moumtzidou Maria Aikaterini
Carpal Tunnel Syndrome
Effectiveness of Desensitisation and Pain Neuroscience Education in Patients With Carpal Tunnel Syndrome With Nosiplastic Pain
The aim of our study was to determine the effectiveness of desensitisation and pain neuroscience education in a group of patients with mixed phenotype pain (neuropathic and nosiplastic).
- Trial name
- NCT06635213
- Testing
- Desensitisation, Pain neuroscience education
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
Diabetic Nephropathy Type 2
Vitamin D in Diabetic Neuropathy
Introduction Diabetic peripheral neuropathy (DPN) is among the most common chronic complications of diabetes mellitus and represents a major cause of morbidity, impaired quality of life, sleep disturbance, chronic pain, and…
- Trial name
- NCT07644520
- Testing
- Vitamin D
- Volunteers
- 150 people
- Sponsor
- Tanta University
Neuralgia
Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots
Moderate to severe neuropathic pain has a prevalence of 5% in the French population, involving the upper limb (UL) in 47%. Invasive neuromodulation, mainly spinal cord stimulation (SCS) is recommended as a third line treatment in…
- Trial name
- SIMPLEX (NCT05817786)
- Testing
- electrical stimulation of the brachial plexus nerve roots
- Where
- 3 sites in France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire de Nice