Clinical trials: Pain Response
Scalp Block
Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients"
The goal of this clinical trial is to learn if an ultrasound-guided scalp block can improve intraoperative hemodynamic stability and provide better postoperative pain relief in adult patients undergoing elective supratentorial…
- Trial name
- NCT07496632
- Testing
- Surgical site infiltration with plain bupivacaine, Scalp block with plain bupivacaine
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- Bangladesh Medical University
Electroencephalography, Critical Care
Sedation Monitoring Using Frontal Electroencephalogram, Electromyogram and Hemodynamic Responses to Pain in Critical Care
Purpose: Assessing nociception and sedation in mechanically ventilated patients in the ICU is challenging, with few reliable methods available for continuous monitoring.
- Conditions
- Electroencephalography, Critical Care, Electromyography
- Trial name
- NCT04472247
- Testing
- Continuous EEG and EMG monitoring, with derived variables
- Where
- 2 sites in Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Neck Pain Musculoskeletal, Chronic Neck Pain
Clinical and Brain Activity Assessment Before and After Physiotherapy in People With Chronic Non-specific Neck Pain
The goal of this clinical trial is to investigate whether electroencephalographic features are associated with the multidimensional clinical characteristics of adults with chronic non-specific neck pain and whether clinical and…
- Trial name
- NCT07756229
- Testing
- Manual physiotherapy and neck-specific exercise programme
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ander Cervantes Benítez
Diabetes, Peripheral Neuropathy
Lidocaine for Diabetic Peripheral Neuropathy
Diabetic nerve pain [painful diabetic peripheral neuropathy] is a common medical problem with few reliably effective treatments.
- Conditions
- Diabetes, Peripheral Neuropathy, Pain
- Trial name
- NCT02363803
- Testing
- lidocaine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
Chronic Low Back Pain, Non Specific Low Back Pain
Which Exercise for Low Back Pain: A Validation Study
Dr. Macedo and others involved in the proposed research recently conducted a study that investigated whether simple clinical characteristics could identify patients who benefit more from either motor control exercises or graded…
- Trial name
- NCT03327753
- Testing
- Motor control exercises, Graded activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Impacted Third Molar Tooth, Pain, Acute
Variability in Analgesic Response to Ibuprofen
Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are recommended as first-line treatment for post-surgical dental pain.
- Trial name
- NCT06539741
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pain, Hyperalgesia
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an…
- Conditions
- Pain, Hyperalgesia, Inflammatory Response
- Trial name
- NCT01301079
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Pain, Neonatal
The Influence of Breastfeeding on Cortical Activity During Procedures
Background: Even the healthiest infants undergo painful procedures as part of universal medical care. Untreated early pain is associated with heightened pain response during later procedures in infancy and alteration in response…
- Trial name
- iCAP (NCT03272594)
- Testing
- Breastfeeding, 24% oral sucrose
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Britney Benoit
Neuropathy, Pain
Pregabalin in CIPN
The investigators seek to investigate certain patient characteristics that would predict the response to a currently approved analgesic, pregabalin, in patients with chronic pain due to nerve damage caused by chemotherapy.
- Trial name
- NCT02394951
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Respiratory Depression
Single Dose Crossover Study to Compare the Respiratory Drive After Administration of Belbuca, Oxycodone and Placebo.
The purpose of this study is to explore and compare VRH after administration of Belbuca, Oxycodone HCl and Placebo in recreational opioid users.
- Trial name
- NCT03996694
- Testing
- Belbuca 300 µg, Belbuca 600 µg, Belbuca 900 µg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- BioDelivery Sciences International
Anesthesia, Pain
Near Infrared Spectroscopy Cortical Response to Noxious and Auditory Stimuli in Subjects Under General Anesthesia
The primary aim is to utilize near-infrared spectroscopy (NIRS) in patients under general anesthesia to measure changes in brain blood flow in the bilateral somatosensory cortices and the prefrontal cortices in response to…
- Trial name
- NCT02703090
- Testing
- Remifentanil, Normal saline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Boston Children's Hospital
Cervical Disc Herniation, Cervical Radicular Pain
Does the Presence of Cervical Facet Tropism Affect the Response to Interlaminar Epidural Steroid Injections?
Facet joints are synovial joints located on the dorsolateral side of the vertebral column. Normally, both facet joints are symmetrical.
- Conditions
- Cervical Disc Herniation, Cervical Radicular Pain, Facet Tropism
- Trial name
- NCT05638074
- Testing
- Interlaminar Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Janbubi Jandaulyet
Dysmenorrhea, Chronic Pelvic Pain
NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)
The goal of this clinical trial is to learn if NSAIDs (i.e. naproxen sodium) can treat menstrual pain and prevent the development of chronic pelvic pain in menstruating adults with painful periods.
- Conditions
- Dysmenorrhea, Chronic Pelvic Pain, Pelvic Pain
- Trial name
- NSAIDHEAL (NCT06861920)
- Testing
- Naproxen Sodium 550mg, Extended Release Acetaminophen (650 mg)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Endeavor Health
Shoulder Arthroscopy, Pain
Intravenous Dexamethasone on Supraclavicular Brachial Plexus Block for Shoulder Arthroscopy
Previous studies have confirmed that IV dexamethasone prolongs brachial plexus blocks. However, these studies only used fixed doses of IV dexamethasone at relatively high doses, which could potentially lead to increased glucose…
- Trial name
- SCB & IV Dex (NCT02688530)
- Testing
- IV Saline, IV Dexamethasone 4mg, IV Dexamethasone 6mg
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pneumoperitoneum, Pain
Effect of Low-pressure Pneumoperitoneum on Pain and Inflammation in Laparoscopic Cholecystectomy
The purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.
- Conditions
- Pneumoperitoneum, Pain, Inflammatory Response
- Trial name
- NCT05530564
- Testing
- low-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- University of Jordan
Vitamin D Deficiency, Chronic Pain Syndrome
The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain
Vitamin D3 is produced in the skin following exposure to UVB light from the sun or artificial sources, and occurs naturally in a small range of foods.More recently, several reports underlined the impact of vitamin D on the…
- Conditions
- Vitamin D Deficiency, Chronic Pain Syndrome, Inflammatory Response
- Trial name
- NCT01417923
- Testing
- vitamin D
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Meir Medical Center
Knee Osteoarthritis
Exercise With Dual Task in Knee Osteoarthritis
The purpose of this study is to evaluate the neuromuscular and perceptual responses, pain intensity and performance in patients with severe knee osteoarthritis in a preoperative setting with low-load resistance training with a…
- Trial name
- DTOA (NCT05280080)
- Testing
- Resistance exercise
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- University of Valencia
Myofascial Pain, Physical Therapy
Myofascial Pain and Central Sensitization
This prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following…
- Trial name
- NCT04929171
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Knee Osteoarthritis, Chronic Knee Pain
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably.
- Trial name
- STAR-GNB (NCT07712419)
- Testing
- Ultrasound-Guided Genicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pain Sensation, Hyperalgesia
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.
- Conditions
- Pain Sensation, Hyperalgesia, Allodynia
- Trial name
- CANAB I (NCT03985995)
- Testing
- CBD 800 mg p.o
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland