Clinical trials: Pain Reduction
Osteoarthritis Knee Pain
A Study of Duloxetine in Patients With Osteoarthritis Knee Pain
The primary purpose of this study is to determine if duloxetine 60 mg once daily (QD) reduces pain severity in patients with osteoarthritis (OA) knee pain compared with placebo.
- Trial name
- NCT00945945
- Testing
- Duloxetine (DLX)
- Where
- 26 sites in United States, Germany and 6 more
- Volunteers
- 424 people
- Sponsor
- Eli Lilly and Company
Nasal Fracture
Efficacy of L/A Spray andL/A-soaked Nasal Packings on Postoperative Pain After Nasal Closed Reduction
This study is perfored to investigate the efficacy of preoperative lidocaine spray and lidocaine-bupivacaine mixture-soaked nasal packing for acute postoperative pain after nasal closed reduction surgery.
- Trial name
- NCT03733275
- Testing
- Lidocaine
- Where
- 2 sites in South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Retinal Disease
SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- RELIEF (NCT05747430)
- Testing
- IRX-101, Providone-Iodine
- Where
- 7 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Burns, Virtual Reality
Virtual Reality and Coping with Procedural Pain in Burn Patients
The main aim of the project is to reduce the feeling of procedural pain (when changing bandages) in burn patients through a developed and pilot-verified application for virtual reality (hereinafter VR).
- Conditions
- Burns, Virtual Reality, Anxiety, Pain
- Trial name
- VRZPB (NCT06596837)
- Testing
- virtual reality
- Where
- Czechia
- Volunteers
- 71 people
- Sponsor
- Martin Zielina
Wound, Anesthesia, Local
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT03676556
- Testing
- Lidocaine, Saline Solution
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Universitari de Bellvitge
Labor Pain
Effects of Massage With Peppermint Oil on Labor Pain
Birth is a very special experience for a woman and her family. Labor pain is one of the strongest known and defined pains today.
- Trial name
- NCT05136066
- Testing
- massage with peppermint oil
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Systemic Lupus Erythematosus
Study of Duloxetine in the Reduction of Pain in Patient With Systemic Lupus Erythematosus
The purpose of this study is to determine whether Duloxetine (cymbalta) can reduce pain severity in patient with Systemic Lupus Erythematosus.
- Trial name
- NCT01269866
- Testing
- Cymbalta
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Dr. Jesus Gutierrez Stone
Pain
Electrical Stimulation Over Acupuncture Points in Reduction of Rectal Discomfort Distension
Colonoscopy is a stressful and unpleasant procedure especially during the passage of the endoscope through angulations of colon. Electro-acupuncture is one of the alternative to reduce colorectal discomfort.
- Trial name
- NCT01551654
- Testing
- Transcutaneous Electrical Nerve Stimulation (ITO Company )
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Bladder Carcinoma
Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy
This randomized phase II/III trial studies gabapentin in reducing the need for pain medication in patients with bladder cancer undergoing surgery to remove the bladder and nearby tissue and organs.
- Trial name
- NCT02355886
- Testing
- Gabapentin, Questionnaire Administration
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Washington
Postherpetic Neuralgia
Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)
The purpose of the study is to evaluate the efficacy of retigabine vs. placebo in reducing pain associated with post-herpetic neuralgia.
- Trial name
- NCT00612105
- Testing
- Retigabine
- Where
- 45 sites in United States, South Africa
- Volunteers
- 187 people
- Sponsor
- Bausch Health Americas, Inc.
Pain
Effectiveness of Helfer Skin Tap Technique and ShotBlocker Technique
The purpose of this study is to examine the effectiveness of the Helfer Skin Tap Technique and the ShotBlocker Technique in reducing pain in babies receiving intramuscular vaccination.
- Trial name
- NCT06246266
- Testing
- Helfer Skin Tap Technique group, ShotBlocker Technique group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Apnea of Prematurity, Retinopathy of Prematurity
Use of Sucrose to Relieve Pain During Eye Exams in Infants
The purpose of this study is to see if an oral sucrose solution can comfort premature infants during their necessary eye exams. The investigators believe that the use of this solution prior to the eye exams will lead to a…
- Conditions
- Apnea of Prematurity, Retinopathy of Prematurity, Pain
- Trial name
- NCT00161694
- Testing
- sucrose solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Oocyte Retrieival and Post Operative Pain Control, Acupuncture
ACU-TENS on Pain and Stress Reduction Before and During TUGOR
Objectives: To demonstrate the use of acupuncture-type transcutaneous electrical nerve stimulation (acu-TENS) during transvaginal ultrasound-guided oocyte retrieval (TUGOR) will reduce 50% of the intensity of pain experienced by…
- Trial name
- NCT06910540
- Testing
- Acu-TENS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Chinese University of Hong Kong
Contraception
Effect of Oral Tramadol Administration Prior to IUD Insertion
the aim of the study is to evaluate the safety and efficacy of oral tramadol administration in reducing pain during LNG- IUD insertion in adolescents and young women
- Trial name
- NCT04312061
- Testing
- oral tramadol
- Volunteers
- 108 people
- Sponsor
- Cairo University
Bone Metastases
Palliation: the Effect of Education on Pain
Rationale: Although radiotherapy is an effective palliative treatment for patients with painful bone metastases with over 70% responders, pain intensity is not always sufficiently controlled.
- Trial name
- PEEP (NCT01358539)
- Testing
- Pain education
- Where
- Netherlands
- Volunteers
- 354 people
- Sponsor
- University Medical Center Groningen
Temporomandibular Joint Disorders
Adding Core Stabilization Training to Manuel Therapy in Temporomandibular Joint Disorders
This study aims to compare the effectiveness of three different treatment approaches in individuals with DDwR symptoms. It is hypothesized that adding core stabilization training (CST) to orofacial manual therapy (OMT) will…
- Trial name
- NCT05607823
- Testing
- Core Stabilization Training, Orofacial Manual Therapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Marmara University
Pain
Photobiomodulation on Pain Perception During the Insertion of the T 380 Copper Intrauterine Device (IUD)
Unplanned pregnancy affects up to 65% of women in some regions of Brazil, contributing to unsafe abortions and maternal mortality.
- Trial name
- NCT06984796
- Testing
- Photobiomodulation, Simulation of Photobiomodulation
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Ostheoporosis of the Knee
Efficacy and Mechanisms of Energy Medicine to Decrease Chronic Knee Pain in Outpatient Settings
This study will assess the efficacy and mechanisms behind Energy Medicine in reducing chronic knee pain within an outpatient setting.
- Trial name
- NCT03637595
- Testing
- Acupuncture, Enery Medicine Intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Osteoarthritis
Methotrexate in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is a common disabling condition, for which no effective therapy currently exists.Synovitis is commonly demonstrated in knee OA imaging.
- Trial name
- NCT01654575
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- University of Alexandria
Burns, Pain
Effects of Virtual Reality Application on Pain Reduction and Cerebral Blood Flow in Robot Training in Burn Patients
The purpose of this study is to determine whether the application of virtual reality (VR) is effective in reducing training pain in robot-assisted gait training (RAGT) in patients with lower extremity burn.
- Conditions
- Burns, Pain, Virtual Reality
- Trial name
- NCT05004766
- Testing
- Robot assisted gait training with virtual reality
- Volunteers
- 10 people
- Sponsor
- Hangang Sacred Heart Hospital