Clinical trials: Pain Reduction
Haemostatic, Bacterial De-contamination
Pilot Study,Diode Laser 808 nm Supported Direct Pulp Capping in Permanent Teeth
The purpose of this study was to compare the conventional and diode 808 nm laser-assisted techniques in direct pulp capping in permanent teeth .The present study was based on a series of ten clinical studies with pulp exposure…
- Conditions
- Haemostatic, Bacterial De-contamination, Bio-stimulation, Reparative Dentine Formation
- Trial name
- Laser in DPC (NCT01907919)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yazdanfar, Iraj, M.D.
Post-herpetic Neuralgia
Dose Response Study of EMA401 in Patients With Post-herpetic Neuralgia (PHN)
This study was designed to characterize dose response, and evaluate safety and efficacy of three different doses of EMA401 compared to placebo in patients with post-herpetic neuralgia (PHN).
- Trial name
- EMPHENE (NCT03094195)
- Testing
- EMA401
- Where
- 58 sites in Australia, Austria and 17 more
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Labor Pain
Intermittent Automated Devices for Labor Analgesia in Emilia Romagna
The study aims to determine whether the use of automated intermittent devices for labor analgesia could prevent the increase of instrumental deliveries, with same analgesia.
- Trial name
- PA-RER (NCT02710877)
- Testing
- Programmed Intermittent bolus, Manual epidural bolus, Levobupivacaine
- Where
- 3 sites in Italy
- Volunteers
- 671 people
- Sponsor
- University of Modena and Reggio Emilia
Inflammation, Pain
Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation
The purpose of this study is to evaluate the clinical efficacy and safety of XG-102 (900µg) compared to vehicle in the treatment of subjects with inflammation and pain following cataract surgery.
- Conditions
- Inflammation, Pain, Cataract
- Trial name
- NCT02235272
- Testing
- XG-102
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Xigen SA
Wound and Injuries, Pain
Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting
Chronic wounds, such as those caused by diabetes, burns, or poor blood circulation, often heal slowly and can cause significant pain, affecting daily life and quality of life.
- Trial name
- PAINFAT (NCT07480447)
- Testing
- Autologous Fat Grafting, Standard Wound Care
- Volunteers
- 62 people
- Sponsor
- King Edward Medical University
Chronic Pain
Acupuncture for Chronic Pain
Chronic pain is a significant public health problem, associated with impairments of physical and psychological functioning. While a third or more of the general population may suffer from chronic pain, it is often under…
- Trial name
- ADDOPT (NCT01149317)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Albert Einstein College of Medicine
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Phantom Limb Pain
Comparison of Efficacy of Mirror Therapy vs Mental Imagery in Reduction of Phantom Limb Pain in AKAP
Limb amputation results in many types of pain, including localized pain at the stump and projected pain experienced by the patient in the location where the amputated limb used to be, known as phantom limb pain (PLP).
- Trial name
- NCT06428123
- Testing
- Mirror Therapy on present Lower Limb, Mental Imagery on present Lower Limb
- Where
- 2 sites in Pakistan
- Volunteers
- 24 people
- Sponsor
- Superior University
Chronic Low Back Pain
Reducing Sedentary Behavior to Decrease Low Back Pain: Stand Back Study
This study will test the effects of a sedentary behavior intervention on low back pain in working adults. The behavioral intervention will include the use of a sit-stand desk and a wrist-worn activity prompter that will notify…
- Trial name
- StandBack (NCT02624687)
- Testing
- Intervention, No intervention
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pelvic Organ Prolapse, Postoperative Pain
Does the Use of Bupivacaine Soaked Vaginal Packing Following Vaginal Surgery Decrease Postoperative Pain?
In current practice, packing in the vagina overnight after vaginal surgery is typically used to prevent post-surgical vaginal bleeding.
- Trial name
- NCT03266926
- Testing
- Bupivacaine, Premarin Vaginal cream
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Injections, Intravenous
Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain
Intravenous lidocaine is commonly given through an intravenous (IV) line prior to injection of propofol to reduce the amount of pain during propofol injection.
- Trial name
- NCT03057704
- Testing
- Lidocaine injection flushed, Lidocaine injection tourniquet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Pelvic Organ Prolapse, Stress Urinary Incontinence
Lidocaine for Pessary Check Pain Reduction
The primary objective of this study is to estimate the effect of lidocaine jelly on patient pain at the time of office pessary removal.
- Trial name
- NCT05493735
- Testing
- Lidocaine Hcl 2% Jelly
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Cervical Spine Fusion
Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery
The goal of this randomized, double-blinded, clinical trial is to assess the benefit of administering a Multifidus Cervicis Plane (MCP) block compared to a sham block as a method of postoperative pain control in patients…
- Trial name
- MCP (NCT05996133)
- Testing
- Bupivacaine Hcl 0.25% Inj, Normal saline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Hartford Hospital
Migraine
A Study Evaluating the Effectiveness of PEA Compared to Placebo for Reducing Pain Severity and Duration of Migraines.
This is a double-blind randomised controlled study to evaluate the effectiveness of orally-dosed Palmitoylethanolamide (PEA) compared to placebo for reducing pain severity and duration of migraines in otherwise healthy…
- Trial name
- NCT05046522
- Testing
- Palmitoylethanolamide sold as Levagen +
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd
Postoperative Pain
RADA16 for Adult Tonsillectomy
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following tonsillectomy procedures.
- Trial name
- NCT07060495
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey
No Condition, Assessment of Healthy Volunteers
Usefulness of Intraosseous Anesthesia for Permanent Tooth Extraction Under GA in Pediatric Dental Treatment
The investigators are doing a study to see if a new way of giving local anesthesia during dental surgery can help children feel better after having a tooth removed under general anesthesia (when they are fully asleep).
- Trial name
- NCT07108439
- Testing
- Administration of intra-osseous local anesthesia before the extraction of a first permanent molar under general anesthesia
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Postoperative Pain
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.
ECS is a very common procedure. A 1-year retrospective survey revealed a vast opioid consumption among the new mothers of approximately (mean±SD) 35±25 mg of oral morphine in the first 24 postoperative hours despite a multimodal…
- Trial name
- NCT03068260
- Testing
- Ropivacaine, Saline, Acetaminophen
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Analgesic Effects of Music
The Sedative Effects of Music Listening on Pain During Cold Pressor Test
This study aims to understand whether listening to music can reduce pain and anxiety caused by a cold-temperature stimulus in healthy young adults (n = 30).
- Trial name
- ESEMP (NCT07515196)
- Testing
- Phase 1 - Silence (Baseline), Phase 2 - Happy Mode with Measured Rhythm, Phase 3 - Sad Mode with Measured Rhythm
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rawane El Dimachki
Stress, Pain, Acute
Comparison of the Effectiveness of Two Different Methods in Reducing Pain and Anxiety
Aim: This study was conducted to determine the effect of distraction techniques (breathing exercises and stress ball squeezing) applied to adults during blood collection on pain and anxiety.
- Trial name
- NCT07616869
- Testing
- stress ball, breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Manisa Celal Bayar University