Clinical trials: Pain Cancer
Painful Bone Metastases, Breast Carcinoma
MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases
This study will evaluate treatment with High Intensity Focused Ultrasound (HIFU)in combination with ThermoDox (liposomal doxorubicin) is safe and effective in reducing pain for patients with painful bone metastases.
- Conditions
- Painful Bone Metastases, Breast Carcinoma, Non-small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- NCT01640847
- Testing
- High Intensity Focused Ultrasound (HIFU) in combination with ThermoDox
- Sponsor
- Imunon
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Pain
Ameliorating the Obstacle of Pap Smear
To reduce the procedural pain of Pap smear, this study expects to apply the peak-end rule to Pap smear by prolonging the insertion of speculum after samples are obtained from the cervix.
- Trial name
- NCT04420208
- Testing
- Modified Pap test
- Where
- Taiwan
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cancer, Constipation
Tolerability, Safety, and Feasibility of Naloxegol in Patients With Cancer and OIC (Opioid Induced Constipation)
The purpose of this study is to determine if naloxegol can be used in the treatment of opioid-induced constipation in patients with cancer and pain.
- Conditions
- Cancer, Constipation, Pain
- Trial name
- NCT02839889
- Testing
- Naloxegol
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Hospice of Henderson County, Inc.
Chronic Pain
Morphine as First Drug for Cancer Pain
Background and Objectives: The drugs used as recommended by the WHO does not promote pain relief for all patients with cancer pain.
- Trial name
- NCT01541124
- Testing
- Opioid
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Pain, Breast Cancer
Pilot Functional Imaging Study to Evaluate Mechanisms Underlying Chronic Pain in Breast Cancer Patients
The purpose of this study is to better understand why some women with breast cancer develop chronic pain.
- Trial name
- NCT01639417
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Lynn Henry
Shoulder Pain, Head and Neck Cancer
Reliability and Validity of Patient Reported Outcome Measures in Head and Neck Cancer
This study will utilize Rasch analysis to study the construct validity and reliability of five shoulder-related patient-reported outcome measures in patients reporting shoulder impairment following surgery for head and neck…
- Trial name
- NCT02554968
- Testing
- Questionnaires
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- Mayo Clinic
Postoperative Pain, Breast Cancer
Administration of Ketamine to Prevent the Post-operative Pain
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse…
- Trial name
- KETAMINE (NCT00210210)
- Testing
- Ketamine, Saline solution
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Institut Bergonié
Analgesia, Lung Cancer
Perioperative Music Therapy Plus Oxycodone in Perioperative Management of Lung Surgery
To explore the feasibility and effectiveness of Perioperative Music Therapy Plus Oxycodone in pain management after thoracic surgery, patients will be randomly assigned into two groups.
- Trial name
- NCT05981924
- Testing
- Perioperative Music Therapy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Hao Long
Vulvar Cancers, Vulva Neoplasm
Needlefree Lidocaine Application for Vulvar Biopsies
The goal of this study is to compare pain during a vulvar biopsy using either the needle-free J-Tip device or the standard lidocaine shot.
- Conditions
- Vulvar Cancers, Vulva Neoplasm, Vulvar Dysplasia
- Trial name
- NCT07793552
- Testing
- J-Tip, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Breast Cancer, Hypercalcemia of Malignancy
Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Zoledronate may prevent bone loss and stop the growth of tumor cells in bone.
- Conditions
- Breast Cancer, Hypercalcemia of Malignancy, Metastatic Cancer, Pain
- Trial name
- NCT00060138
- Testing
- monoclonal antibody CAL, zoledronic acid
- Where
- United States
- Sponsor
- Chugai Pharmaceutical
Pain
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model
This exploratory study will use a thermal-grill experimental model to assess the effects of JNJ-39439335 (50 mg, single oral dose) on the relief of pain.
- Trial name
- NCT01006304
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Nausea, Vomiting
Effect of a Symptom Diary on Symptom Care and Symptom Burden in Patients Treated With Chemotherapy: a Before-and-after-study
This study investigates whether the implementation of a symptom diary for reporting and communicating chemotherapy-related symptoms improves symptom care and decreases symptom burden in adult patients treated with chemotherapy.
- Conditions
- Nausea, Vomiting, Pain, Anorexia
- Trial name
- NCT02050490
- Where
- Belgium
- Volunteers
- 236 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Dyspareunia
Vaginal Dilator Therapy Among Women With Gynecologic and Breast Cancers Experiencing Dyspareunia
In this randomized controlled trial, the investigators will assess the difference in mean patient-reported pain scores and sexual function between women with gynecologic or breast cancers experiencing dyspareunia (painful…
- Trial name
- NCT05129332
- Testing
- Vaginal Moisturizer, Vaginal Dilator
- Where
- 2 sites in United States
- Sponsor
- Columbia University
Breast Cancer, Postoperative Pain
Comparison of Postoperative Analgesic Efficacy of Two Different Blocks in Modified Radical Mastectomy Surgery
Postoperative pain following modified radical mastectomy remains a significant clinical challenge and may delay recovery, impair patient comfort, and increase opioid consumption.
- Trial name
- mastectomy (NCT07737132)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Ultrasound-Guided Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Lung Diseases, Lung Cancers
Optimizing Post-Thoracotomy Pain Management: Comparing Erector Spinae vs. Paravertebral Block in Thoracotomy Patients
This prospective, observational study included ASA class II-III patients aged 18-70 years who underwent elective unilateral lobectomy via a thoracotomy.
- Trial name
- NCT06964698
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck
Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer
Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's…
- Trial name
- QSSC-HN (NCT07823309)
- Testing
- Quad Shot Radiotherapy, Split Course Radiotherapy
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Pain
Safety and Efficacy Study of Osmotic Release Oral System (OROS) Hydromorphone in Participants With Cancer Pain
The purpose of this study is to evaluate the effectiveness and safety of Osmotic Release Oral System (OROS) hydromorphone using standardized conversion from prior opioid therapy among participants with cancer pain.
- Trial name
- NCT01648699
- Testing
- Osmotic Release Oral System (OROS) hydromorphone
- Volunteers
- 20 people
- Sponsor
- Janssen Pharmaceutica
Catheter Complications
Port Catheter Needle Insert: A Virtual Reality Application
The study was randomized controlled to examine the effect of virtual reality (VR) application on pain, anxiety, and vital signs associated with port catheter needle insertion.
- Trial name
- NCT05950789
- Testing
- Virtual reality application
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Izmir Bakircay University