Clinical trials: Pain, Acute
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Acute Pain, Virtual Reality
Effects of Virtual Reality Glasses, Kaleidoscope and Distraction Cards on Pain and Anxiety During Blood Draw in Children
The study was designed as a randomized controlled experimental research with the purpose of determining the effect of distraction by using Virtual Reality Glasses, Kaleidoscope and Distraction Cards in reducing pain and anxiety…
- Conditions
- Acute Pain, Virtual Reality, Kaleidoscope, Distraction Cards
- Trial name
- NCT06192498
- Testing
- Virtual Reality Glasses, Kaleidoscope, Distraction Cards
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Burdur Mehmet Akif Ersoy University
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Acute Pain
CoPainHell: The Analgesic Effect of Alcohol and Music
The study is a 2x2 randomized crossover study. Participants are randomized to listen to one of two music tracks: "Orinoco Flow" by Enya or "Raining Blood" by Slayer.
- Trial name
- CPH (NCT06471985)
- Testing
- Music and pain
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eske Kvanner Aasvang
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Acute, Post-operative Pain
Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427
This randomized, double-blind, placebo controlled, study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of ST-2427.
- Trial name
- NCT04475198
- Testing
- ST-2427
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SiteOne Therapeutics, Inc.
Pain, Acute, Satisfaction
Observational Peripheral IV Insertion Study
IV placement is a common and necessary for surgical procedures. Unfortunately, pain associated with needle catheterization experienced during peripheral IV placement is a source anxiety and discomfort in many patients.
- Trial name
- NCT04762121
- Testing
- Peripheral IV
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Healthy
Environmental Game After Appendicitis Surgery
This study was conducted to determine the effect of environmental play and mobilization on fear and pain levels of children aged 6-12 years who had acute appendicitis surgery.
- Trial name
- NCT05104021
- Testing
- game
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Okan University
Acute Pain, Pain, Acute
Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers
This study will be conducted to assess safety, tolerability, and PK of CT-044 HCl in normal healthy volunteers, in a traditional sequential multiple ascending dose paradigm.
- Conditions
- Acute Pain, Pain, Acute, Surgery, Neuropathy
- Trial name
- NCT04175743
- Testing
- CT-044 HCl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
Acute Pain, Experimental Pain in Healthy Human Participants
Healthy Children and Virtual Reality Mediation of Simulated Pain
The objective of this study is to develop central nervous system (CNS) biomarkers of pain experienced during medical procedures and pain relief induced by Virtual Reality Pain Alleviation Therapy (VR-PAT).
- Conditions
- Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
- Trial name
- NCT06854991
- Testing
- Active VR-PAT, Passive VR-PAT, iPad
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Sickle Cell Anemia Crisis
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
- Trial name
- NCT03541980
- Testing
- Acetaminophen, Normal saline
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Newark Beth Israel Medical Center
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Migraine Disorders, Migraine Headache
The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
The purpose of this study is to evaluate the efficacy and safety of intra-oral topical ketoprofen for the treatment of acute migraine.
- Conditions
- Migraine Disorders, Migraine Headache, Migraine, Acute Migraine
- Trial name
- NCT01228552
- Testing
- Topical, intra-oral ketoprofen gel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Behar, Caren, M.D.
Procedural Pain, Acute Pain
Fan-Assisted Local Cooling for Pain During Intravenous Cannulation in Adults
Inserting an intravenous (IV) cannula is one of the most frequently performed procedures in clinical practice, and it is commonly experienced as painful. Before the needle is inserted, the skin is routinely cleaned with alcohol.
- Conditions
- Procedural Pain, Acute Pain, Peripheral Intravenous Catheterization
- Trial name
- NCT07740837
- Testing
- Fan-assisted local cooling, Standard alcohol skin preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Antalya Health Sciences University
Postoperative Pain, Acute, Postoperative Nausea and Vomiting
The Impact of Breath Exercise Training on Postoperative Pain, Anxiety, and Nausea-Vomiting in General Surgery Patients
This study was conducted to determine the effect of breath exercise on post-operative anxiety level, pain, and nausea-vomiting after general surgery. This was a randomized, controlled experimental study.
- Conditions
- Postoperative Pain, Acute, Postoperative Nausea and Vomiting, Patient Relations, Nurse
- Trial name
- NCT06546514
- Testing
- Breath Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Pain, Acute, Congenital Heart Disease
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Postoperative pain after cardiothoracic surgery can be a significant problem interfering with recovery, yet difficult to manage due to the sedating effects of opiates.
- Trial name
- TTPPCT (NCT04138745)
- Testing
- Transverse Thoracic Plane Block
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Pain Threshold, Pain Tolerance
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser…
- Conditions
- Pain Threshold, Pain Tolerance, Acute Pain, Low-level Laser Therapy
- Trial name
- NCT07422272
- Testing
- Low-Level Laser Therapy (LLLT)
- Where
- Cyprus
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Infant Development, Nurse's Role
The Effects of Acupressure and Paternal Holding on Pain and Physiological Parameters During Heel Lancing
Neonatal heel blood collection is a common medical procedure to obtain blood samples from newborns for diagnostic purposes. Although necessary for clinical evaluation, this procedure causes discomfort and distress in infants.
- Conditions
- Infant Development, Nurse's Role, Pain, Acute
- Trial name
- NCT06513897
- Testing
- Acupressure, Father's Lap
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Baskent University
Acute Pain, Nursing Caries
Effects of Distraction Methods on Pain Perceptions and Anxiety Levels in Children During the Blood Collection
Aim:This study was conducted to investigate the effects of music, kaleidoscope and video watching methods on children's pain perception and anxiety level during the blood collection procedures.
- Trial name
- NCT04113980
- Testing
- music group, kaleidoscope group, video group
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Acute Pain
Efficacy of XP20B Following Bunionectomy Surgery
The purpose of this study is to determine if XP20B is an effective treatment for the relief of pain following bunionectomy surgery.
- Trial name
- NCT00655291
- Testing
- XP20B
- Where
- 6 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Xanodyne Pharmaceuticals