Clinical trials: Paediatric
Anti-NMDAR Encephalitis
Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis
The purpose of the study is to assess the efficacy of immunoadsorption therapy (IA) on improving the neurological status of severe pediatric anti-NMDAR encephalitis patients.
- Trial name
- IANMDAR (NCT03274375)
- Testing
- IA session, Rituximab
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease, Sickle Cell Anemia in Children
Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease
The goal of this interventional study is to learn about the impact of an intervention for health care providers that teaches individuation and perspective-taking (IPT) skills to enhance patient-centered communication in pediatric…
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia in Children, Sickle Cell Disease (SCD), Sickle Cell
- Trial name
- NCT07540767
- Testing
- Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Pain
iMpact of therapeUtic Live muSic on Pain and Distress Levels During Interventions in the paediatriC Emergency Department
The Emergency Department (ED) can be stressful and traumatic, especially for children and young people, and the clinical environment can be a frightening, unfamiliar space, which adds to an already anxious experience.
- Trial name
- Music:ED (NCT03956667)
- Testing
- Live Music
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Cervical Cancer, Genital Warts
A Controlled Trial to Assess the Immunogenicity of a Proposed Paediatric Dosing Schedule of Human Papillomavirus Vaccine
Primary objective is to determine if antibody responses to HPV types 16 \& 18 are non-inferior after a 2-dose paediatric regimen as compared to a 3-dose adult regimen of Q-HPV vaccination, with responses measured at Month 7.
- Trial name
- BCGov-01 (NCT00501137)
- Testing
- HPV (Human Papillomavirus) Vaccine
- Where
- Canada
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Simon Dobson
Sacral Erector Spinae Plane Block, Caudal Block
Sacral Erector Spinae Plane Block Versus Caudal Block in Penile Surgeries in Pediatrics
The study will be conducted to compare the efficacy of ultrasound guided Sacral Erector Spinae Plane Block to caudal block on pain management in penile surgeries in pediatrics.
- Conditions
- Sacral Erector Spinae Plane Block, Caudal Block, Penile Surgeries, Pediatrics
- Trial name
- NCT06235944
- Testing
- Caudal block, Sacral erector spinae block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Mild Traumatic Brain Injury
BLOOD BIOMARKERS in PAEDIATRIC MTBI
The goal of this observational study is to identify blood biomarkers that could help in the management of paediatric patients with mild TBI. The main questions it aims to answer are: 1.
- Trial name
- t-BIOMAP (NCT06233851)
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Pediatric Clinical Research Platform
Pain
A Comparison of Amethocaine Cream vs. Liposomal Lidocaine Cream for Venipuncture in Children.
All patients undergoing venepuncture or venous cannulation in pediatric emergency department will be treated with either Amethocaine, or Liposomal Lidocaine (4%) cream at the site of cannulation in order to determine the efficacy…
- Trial name
- NCT00353002
- Testing
- Ametop (4% Amethocaine cream ), Maxilene (4% Liposomal Lidocaine)
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cancer
Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations
This was a 4-part (Part A, Part B, Part C and Part D), Phase I/IIa, multi-center, open label, study in pediatric subjects with refractory or recurrent tumors.
- Trial name
- NCT02124772
- Testing
- Trametinib, Dabrafenib
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Gastroenteritis
Palatability of Oral Rehydration Solutions
The primary objective of this study is to compare the mean taste scores for three fruit flavored oral rehydration solutions in children aged 5-10 years old.
- Trial name
- NCT00689312
- Testing
- Enfalyte, Pediatric Electrolyte, Pedialyte
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- The Hospital for Sick Children
Cataract
Evaluation of Therapeutic Strategies in Pediatric Cataract Surgery
The purpose of this observational study is to assess the therapeutic strategies in the treatment of pediatric cataracts.
- Trial name
- EP3C (NCT02253017)
- Testing
- Children operated on for cataract
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between…
- Trial name
- AFAT (NCT05748717)
- Where
- Jamaica
- Volunteers
- 34 people
- Sponsor
- The University of The West Indies
Epilepsy
Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies
When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation.
- Trial name
- COAG (NCT02886650)
- Testing
- Thermocoagulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Scoliosis
Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative…
- Trial name
- NCT00737997
- Testing
- Morphine, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Respiratory Syncytial Virus (RSV), Lower Resp Tract Infection
A Study to Learn About the Effects of Sisunatovir in Infants With Respiratory Syncytial Virus Lower Respiratory Tract Infection.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (sisunatovir). Sisunatovir is developed as potential treatment of Respiratory Syncytial Virus (RSV) infections.
- Trial name
- REVIRAL 1 (NCT04225897)
- Testing
- RV521
- Where
- 60 sites in Argentina, Canada and 13 more
- Volunteers
- 51 people
- Sponsor
- Pfizer
Hepatitis C, Chronic, Hematologic Malignancy
Pharmacokinetics of Ledipasvir/Sofosbuvir in Hepatitis C Virus-Infected Children With Hematological Malignancy
This is a prospective, controlled, open-label, pharmacokinetic study. This study aims at studying the PK of ledipasvir, sofosbuvir, and GS-331007 metabolite in HCV infected children with hematological malignancy.
- Trial name
- NCT03903185
- Testing
- Ledipasvir / Sofosbuvir Oral Product
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Attention Deficit Hyperactivity Disorder (ADHD)
Effectiveness of Manual Therapy in the Treatment of Attention Deficit Hyperactivity Disorder
The main objective is to determine whether Manual Therapy (MT), in addition to conventional treatment, is more effective in improving ADHD symptoms than the application of conventional treatment alone.
- Trial name
- MT-ADHD (NCT07029425)
- Testing
- Procedure: craniosacral therapy techniques.
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- JJ JIMENEZ-REJANO
Vaccination/Immunisation Status
Vaccination Coverage Amongst Children/Young People Attending the PED
In the United Kingdom (UK), most childhood vaccinations are given in the community, although uptake has decreased in recent years.
- Trial name
- NCT04485624
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 2,693 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Shock
Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study
Approximately 20,000 children per year in North America present to the hospital with severe shock. Children who develop this condition have very low blood pressures and as a result may suffer damage to their internal organs and…
- Trial name
- STRIPES (NCT02044159)
- Testing
- Hydrocortisone
- Where
- 7 sites in Canada
- Volunteers
- 57 people
- Sponsor
- Children's Hospital of Eastern Ontario
Infectious Diseases
BAY 0 9867 Cipro Pediatric Use Study (QUIP)
Objective and subjective musculoskeletal evaluations will be performed to determine differences in the ciprofloxacin versus non-quinolone treated pediatric patients so that we can tell what the natural occurrence of such…
- Trial name
- NCT00761462
- Testing
- Ciprofloxacin, Non-quinolone antibiotic
- Where
- 67 sites in United States, Canada
- Volunteers
- 1,029 people
- Sponsor
- Bayer
Brain Tumors
A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas
This study is for patients up to 21 years of age who have a tumor called a low grade glioma of the central nervous system (brain and spinal cord). The tumor has grown despite attempts to control it with chemotherapy or radiation.
- Trial name
- Poly-ICLC (NCT01188096)
- Testing
- Poly ICLC
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences