Clinical trials: PTSD and Alcohol Use Disorder
Alcohol; Use, Problem, Posttraumatic Stress Disorder
Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault
Sexual assault can lead to devastating consequences including the development of chronic conditions including posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD).
- Trial name
- NCT04124380
- Testing
- Imaginal Exposure, Alcohol Skills Training, Supportive Telehealth
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Washington
PTSD, Alcohol Abuse
Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD
The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).
- Conditions
- PTSD, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01663337
- Testing
- Cognitive Processing Therapy (CPT), Relapse Prevention (RP)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- University of Washington
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
Post Traumatic Stress Disorder, Alcohol Use Disorder
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD
This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD.
- Trial name
- NCT03667846
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Posttraumatic Stress Disorder, Alcohol Use
CBT Texts for PTSD & Hazardous Drinking (Project Better)
The research study seeks to refine and test a brief, self-directed, intervention for individuals from the general public with PTSD and co-occurring HD that can be delivered via text-messaging.
- Trial name
- NCT05372042
- Testing
- CBT Text Messages
- Where
- United States
- Volunteers
- 505 people
- Sponsor
- University of Washington
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
PTSD, Alcohol Use Disorder
Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
The investigators propose to conduct a clinical trial to evaluate sertraline treatment efficacy in a large sample of military veterans with a dual diagnosis of PTSD and Alcohol Use Disorder who are receiving Cognitive and…
- Trial name
- DDx (NCT02504931)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
PTSD, Substance Use Disorders
Alcohol Use Disorders (AUDs) and Post-traumatic Stress Disorder (PTSD) Treatment for Victims of Partner Violence
The goal of this study is to evaluate a psychotherapy for PTSD and substance use disorders among women who have experienced domestic violence.
- Trial name
- NCT00607412
- Testing
- Integrated psychotherapy for PTSD and substance use, 12-step based supportive therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
PTSD and Alcohol Use Disorder
Topiramate and Prolonged Exposure
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Trial name
- TOP (NCT03176953)
- Testing
- topiramate, prolonged exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
PTSD, AUD
PTSD and Alcohol Couples Treatment for Veterans
Treatment of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) treatment for Veterans is challenging for Veterans.
- Trial name
- PACT-V (NCT07388654)
- Testing
- COPE + BFIT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms
Personalizing Treatment Delivery
Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society.
- Conditions
- Anxiety Disorders and Symptoms, PTSD and Trauma-related Symptoms, Alcohol; Use, Problem; Alcohol Use Disorder
- Trial name
- NCT05821634
- Testing
- Personalized intervention condition: Cognitive behavioral therapy skills, Therapeutic control condition: Cognitive behavioral therapy skills, Tracking control condition: Supportive counseling
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Dependence, Stress Disorders, Post-Traumatic
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence.
- Trial name
- NCT00744055
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD)
NAC for Treating Comorbid PTSD and SUD
As a result of sustained operations in Afghanistan and Iraq, there are an increasing number of U.S. military Veterans with substance use disorders and comorbid posttraumatic stress disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
- Trial name
- DoD-NAC (NCT02911285)
- Testing
- N-acetylcysteine, Cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder, Alcohol Use Disorder
Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes
The purpose of this study is to learn whether a mobile health application (mHealth App) for posttraumatic stress disorder (PTSD) with brief support can help individuals who are in treatment for alcohol problems.
- Trial name
- NCT05564663
- Testing
- PTSD Coach App + Brief Support, Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Michigan State University
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
PTSD, Alcohol Abuse
Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy
The proposed project aims to: 1. Obtain a preliminary assessment of the efficacy of topiramate treatment in reducing alcohol use in veterans with Post Traumatic Stress Disorder (PTSD) and alcohol dependence; 2.
- Conditions
- PTSD, Alcohol Abuse, Alcoholism
- Trial name
- TAP (NCT01087736)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder, Post Traumatic Stress Disorder
MDMA for AUD/PTSD Comorbidity
The study investigators are conducting the first open label pilot trial of MDMA-assisted therapy (MDMA-AT) with a comorbid sample of military veterans with a comorbid diagnosis of Alcohol Use Disorder (AUD) and Post-Traumatic…
- Trial name
- MDMA (NCT05943665)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Carolina L Haass-Koffler
Post Traumatic Stress Disorder, Alcohol Use Disorder
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and…
- Trial name
- MAP VETS (NCT07118839)
- Testing
- Full Dose MDMA, MDMA-Assisted psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development