Clinical trials: PTSD
Posttraumatic Stress Disorder, Chronic Pain
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Cognitive Processing Therapy (CPT) is an effective first-line, evidence-based treatment for posttraumatic stress disorder (PTSD).
- Trial name
- SGB (NCT05534126)
- Testing
- Stellate Ganglion Block Treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD)
Project COMET: Massed Prolonged Exposure for PTSD and SUD
The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Substance Use Disorders (SUD), Comorbidity, Trauma and Stressor Related Disorders
- Trial name
- PROJECT COMET (NCT06968832)
- Testing
- Massed Prolonged Exposure Therapy (M-PE), Standard outpatient SUD care
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Rutgers, The State University of New Jersey
Post Traumatic Stress Disorder
eTMS for Veterans and First Responders With PTSD
A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD.
- Trial name
- NCT06294106
- Testing
- Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University
PTSD
Delivery of Self Training and Education for Stressful Situations-Telephone Version
This study will evaluate a telephone-delivered cognitive-behavioral psychotherapy intervention designed for primary care treatment of combat-exposed service members with PTSD.
- Trial name
- DESTRESS-T (NCT01502449)
- Testing
- DESTRESS-T, Optimized Usual Care (OUC)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Uniformed Services University of the Health Sciences
PTSD - Post Traumatic Stress Disorder
Psychiatric Nurse-Delivered Eye Movement Desensitization and Reprocessing (EMDR) for Adults With Post-Traumatic Stress Symptoms in Jordan
Here is a plain-language, registry-appropriate Brief Summary you can paste into the form. It is written for patients, families, and healthcare providers: Brief Summary This study examines whether Eye Movement Desensitization and…
- Trial name
- Experimental (NCT07423832)
- Testing
- EMDR
- Where
- Jordan
- Volunteers
- 70 people
- Sponsor
- Al-Quds University
PTSD, Functioning, Psychosocial
What Difficulties Do Children and Adolescents Experience in Everyday Activities After a Traumatic Event? Focus Groups and Delphi Survey for the Development of a Questionnaire on PTSD-related Functional Impairment
Post-traumatic Stress Disorder (PTSD) in children and adolescents is often associated with a myriad of significant impairments in daily functioning, including family relationships, school/work, leisure time activities, and social…
- Trial name
- NCT05984706
- Testing
- Focus groups and Delphi Questionnaire
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Children's Hospital, Zurich
Stress Disorders, Post Traumatic
Treatment of Post-traumatic Stress Disorder With High Doses of Escitalopram
The study evaluates the hypothesis that large doses of Escitalopram will reduce symptoms of chronic post-traumatic stress disorder (PTSD) in adult civilian survivors of traumatic events.
- Trial name
- NCT00736021
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Hadassah Medical Organization
Depressive Disorder, Major, Post Traumatic Stress Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression.
- Conditions
- Depressive Disorder, Major, Post Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT03367533
- Testing
- Ketamine, Perampanel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
PTSD
Comparing Behavioral Therapies for Treating Adolescents With Post-Traumatic Stress Disorder Related to Sexual Abuse
Posttraumatic stress disorder (PTSD) is the most common disorder among childhood sexual abuse survivors and is associated with substantial psychosocial and medical problems, but evidence-based treatment for PTSD in adolescents is…
- Trial name
- NCT02148484
- Testing
- Prolonged Exposure for Adolescents, Client Centered Therapy
- Volunteers
- 90 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Posttraumatic Stress Disorder
Study to Promote Innovation in Rural Integrated Telepsychiatry
Background: Community Health Centers care for over 20 million rural, low income and minority Americans every year. Patients often have complex mental health problems such as Posttraumatic Stress Disorder (PTSD) and Bipolar…
- Trial name
- SPIRIT (NCT02738944)
- Testing
- Telepsychiatry Collaborative Care, Telepsychiatry Enhanced Referral
- Where
- 13 sites in United States
- Volunteers
- 1,004 people
- Sponsor
- University of Washington
Post-Traumatic Stress Disorder
MDMA-assisted Massed Prolonged Exposure for PTSD
The overall objective of this study is to pilot the VASDHS-adapted Emory MDMA-PE Protocol (aE-MDMA-PE) and assess the effect on clinician-rated PTSD symptoms in veterans who receive different doses of MDMA.
- Trial name
- MDMA-PE (NCT06117306)
- Testing
- 3,4 Methylenedioxymethamphetamine, Prolonged Exposure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Healing Breakthrough
Mental Health Disorder, Post Traumatic Stress Disorder
Development of Mental Health Outcomes Following the 2020 Petrinja Earthquake
On 29 December 2020, an earthquake struck Petrinja in Croatia. The aim of this study is to assesses prevalence of symptoms of posttraumatic stress disorder, depression, anxiety, and panic disorder among exposed inhabitants and…
- Conditions
- Mental Health Disorder, Post Traumatic Stress Disorder, Depression, Anxiety
- Trial name
- NCT04911933
- Testing
- Family Therapy
- Where
- Croatia
- Volunteers
- 350 people
- Sponsor
- Neuropsychiatric Hospital dr Ivan Barbot
Stress Disorders, Post-Traumatic, Opioid Use Disorder
New Beginnings Following Trauma
Posttraumatic stress disorder (PTSD) is associated with increased rates of prescription opioid misuse, high-risk opioid use, illicit use of substances, and overdose (Meshberg-Cohen et al., 2021) Some research has demonstrated…
- Trial name
- NCT05817344
- Testing
- Written Exposure Therapy - Integrated
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Jesse McCann
Post Traumatic Stress Disorder, Depression
Electroconvulsive Therapy for Traumatic Memories
This study will investigate whether ECT treatment can reduce the effect of traumatic memories if those memories are recalled immediately prior to the ECT sessions.
- Trial name
- NCT04027452
- Testing
- Traumatic memory reactivation, Neutral memory reactivation
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Centre for Addiction and Mental Health
Stress Disorders, Post-Traumatic
An Integrated Online Program Using Psychoeducation and Expressive Writing for People With Probable Post-traumatic Stress Disorder and Coexisting Dissociative Symptoms
Objectives: To evaluate the feasibility, acceptability, safety, and preliminary effects of an integrated online program with psychoeducation and expressive writing components for people with probable post-traumatic stress…
- Trial name
- NCT06523023
- Testing
- An integrated online program
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
Sleep Apnea Syndromes, Insomnia Disorder
Apnea and Insomnia Relief Study
The purpose of this study is to determine whether a behavioral sleep treatment improves functioning and sleep in Veterans with posttraumatic stress disorder (PTSD).
- Conditions
- Sleep Apnea Syndromes, Insomnia Disorder, Stress Disorders, Post-Traumatic
- Trial name
- AIR (NCT04007796)
- Testing
- Apnea and Insomnia Relief (AIR), Sleep Education (SE)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Depression
The Pitt Center for Emergency Responder Wellness
Emergency responders protect the public despite occupational hazards that threaten their mental health. The Pitt Center for Emergency Responder Wellness will be a clinical innovation hub that: 1) delivers accessible interventions…
- Conditions
- Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
- Trial name
- NCT05357586
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Stress, Emotional, Stress-related Mental Disorders
School-Based Intervention to Enhance Resilience and Stress Coping in Rural Chinese Adolescents
This study aims to evaluate the effectiveness of school-based psychological interventions in improving stress resilience and coping skills among adolescents in rural China.
- Trial name
- EASY (NCT07115186)
- Testing
- Psychoeducation, guided written therapy, wait-list condition
- Where
- China
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Peking University
Combat Disorders, Stress Disorders, Post-Traumatic
Quetiapine Augmentation for Treatment-resistant PTSD
The purpose of this study is to compare the response of veterans with PTSD without an optimal response to paroxetine to quetiapine augmentation versus placebo.
- Trial name
- NCT00292370
- Testing
- Open Label (OL) Paroxetine, Quetiapine
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Imaging the Neuroimmune System in PTSD
In this study, individuals with and without post-traumatic stress disorder (PTSD) will undergo one positron emission tomography (PET) scan using the radiotracer [11C]PBR28, which binds to the 18kDa translocator protein (TSPO).
- Trial name
- NCT04236986
- Testing
- Lipopolysaccharide
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University