Clinical trials: PTSD, injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Condition PTSD
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Major Depressive Disorder, Post Traumatic Stress Disorder
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
This observational registry aims to collect real-world data on ketamine use in psychiatric inpatients within a regional tertiary-reference center.
- Conditions
- Major Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder, Somatoform Disorders
- Trial name
- KetGD (NCT05565352)
- Testing
- Ketamine Hydrochloride
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Medical University of Gdansk
Post Traumatic Stress Disorder, Trauma
Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD
This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older.
- Trial name
- NCT07485231
- Testing
- Beetroot Juice
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Orthopedic Trauma Surgery Patients, Postoperative Pain
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma.
- Conditions
- Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression
- Trial name
- NCT06903819
- Testing
- Ketamine, standard general anesthesia
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Texas Tech University Health Sciences Center
Depressive Disorder, Major Depressive Disorder
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Bipolar Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT05786066
- Testing
- Perampanel 6 MG, Ketamine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Stress Disorders, Post-Traumatic
Combining Stellate Ganglion Block With Prolonged Exposure for PTSD
The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck)…
- Trial name
- NCT05889741
- Testing
- Ropivacaine injection, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder (PTSD)
Inflammatory Challenge and Fear
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear.
- Trial name
- LIFE (NCT06630884)
- Testing
- Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stress Disorders, Post-Traumatic
An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
Given the high prevalence of post-traumatic stress disorder (PTSD) in veterans and active duty military, the focus of this research study is to test the reliability of two new PTSD assessments, the Clinician Administered PTSD…
- Trial name
- NCT04180930
- Testing
- CAPS-5, PSSI-5, CAPS-IV
- Where
- 3 sites in United States
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Chronic Pain, Posttraumatic Stress Disorder (PTSD)
Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD
The goal of this pilot study is to evaluate the feasibility of conducting a clinical trial assessing if ketamine infusions combined to mindfulness therapy works better than psychotherapy alone to treat chronic pain and PTSD in…
- Trial name
- NCT07009158
- Testing
- Ketamine Infusion, Mindfulness-based cognitive therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Dr. Yuliya Knyahnytska
PTSD
Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD
PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be…
- Trial name
- NCT07382596
- Testing
- Dextrose 5% in water bilateral injection, Normal saline bilateral injection
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Dr. Dean Reeves Clinic
PTSD
Efficacy of Cervical Sympathetic Blocks for PTSD
Millions of people suffer from anxiety disorders, including posttraumatic stress disorder (PTSD)-a condition that can profoundly disrupt daily life.
- Trial name
- NCT07087015
- Testing
- Cervical sympathetic nerve block, Ropivacaine, Normal Saline
- Volunteers
- 20 people
- Sponsor
- Stanford University
Post Traumatic Stress Disorder PTSD
The Effects of Stellate Ganglion Block Sleep in U.S. Active Duty Service Members and Veterans Receiving Prolonged Exposure Therapy for PTSD
Participants in this study will have already been enrolled in another research study: Combining Stellate Ganglion Block with Prolonged Exposure for PTSD, NCT05889741.
- Trial name
- NCT07667309
- Testing
- Sleep Profiler Headband
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Borderline Personality Disorder
NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability…
- Trial name
- BorderStress (NCT04852744)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Neuropathic Pain, PTSD
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants.
- Trial name
- NCT06414356
- Testing
- Ketamine, Magnesium sulfate, Ketamine + Magnesium sulfate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Margaux M. Salas, PhD
Complex Post-Traumatic Stress Disorder (CPTSD), Borderline Personality Disorder (BPD)
Study of Emotional Dysregulation in Complex Post-Traumatic Stress Disorder
This study aims to characterize emotional dysregulation in complex post-traumatic stress disorder (cPTSD) and to determine the extent to which it can promote the distinction with borderline personality disorder (BPD) and…
- Conditions
- Complex Post-Traumatic Stress Disorder (CPTSD), Borderline Personality Disorder (BPD), Post-traumatic Stress Disorder (PTSD)
- Trial name
- TR-EMA (NCT06848127)
- Testing
- Self-questionnaires, Cognitive assessment, Momentary Ecological Assessment (EMA)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
PTSD
Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder
The most common treatment for Posttraumatic Stress Disorder (PTSD) is trauma-focused therapy and/or prescription of medication(s).
- Trial name
- NCT05427500
- Testing
- 5 mL of 0.5% preservative-free bupivacaine
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- The Royal's Institute of Mental Health Research
Post Traumatic Stress Disorder
Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD)
Post-traumatic stress disorder (PTSD) is a chronic disorder that develops following exposure to trauma, and is characterized by intrusive experiences, avoidance, cognitive-emotional changes, and hyperarousal.
- Trial name
- NCT07618611
- Testing
- Stellate ganglion block
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- sara dichtwald
PTSD, Chronic Pain
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain.
- Trial name
- NCT05700279
- Testing
- Stellate Ganglion Block, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Rush University Medical Center
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study
The purpose of this research study is to find out how Zulresso®/brexanolone influences Posttraumatic Stress Disorder (PTSD) symptoms and alcohol use.
- Trial name
- NCT06580444
- Testing
- Brexanolone
- Volunteers
- 40 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
PTSD
Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD
The purpose of this study is to understand if we can improve the treatment for posttraumatic stress disorder (PTSD). We are looking into whether the combination of Stellate Ganglion Block (SGB) treatment and Cognitive Processing…
- Trial name
- NCT06570213
- Testing
- Cognitive Processing Therapy, Stellate Ganglion Block
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Rush University Medical Center
Posttraumatic Headache, Posttraumatic Stress Disorder
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD
Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well as in more recent conflicts in…
- Trial name
- NCT06608277
- Testing
- Group A active comparator, Group B active comparator, Group C Experimental
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Northwestern University