Clinical trials: POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Postoperative Cognitive Dysfunction, Postoperative Delirium
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in…
- Trial name
- NCT07192549
- Testing
- Sevoflurane group, Propofol group
- Volunteers
- 200 people
- Sponsor
- General Hospital of Ningxia Medical University
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Cognitive Decline, Postoperative Delirium
Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and…
- Conditions
- Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- INCORE (NCT04493996)
- Testing
- Cognitive training
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heart and Brain Research Group, Germany
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement
Aortic valve stenosis is one of the most common types of heart disease in the aging Western population. While surgical cardiac valve replacement (SAVR) is a standard therapy for patients with aortic stenosis, catheter-assisted…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Transcatheter Aortic Valve Replacement, Surgical Aortic Valve Replacement
- Trial name
- COSTA (NCT04535076)
- Testing
- Transcatheter Aortic Valve Implantation, Surgical Aortic Valve Replacement
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Heart and Brain Research Group, Germany