Clinical trials: PMTCT
HIV-infection/Aids
Community-Based Peer Facilitator Intervention (Zimbabwe)
The goal of this community randomized operations research study was to evaluate the effect of a peer-facilitated community support group intervention on uptake of maternal and neonatal child health (MNCH) and PMTCT services and…
- Trial name
- NCT02496793
- Testing
- Peer-facilitated community support group
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Mental Health Issue, Hiv
Healthy Mothers: an Intervention to Support Perinatal Women Living With HIV in Kenya
The investigators will recruit 40 pregnant women living with HIV divided into 2 groups (n=20 intervention group, n=20 control group).
- Conditions
- Mental Health Issue, Hiv, Breastfeeding, Exclusive
- Trial name
- NCT05219552
- Testing
- personalized lactation support
- Where
- 2 sites in Kenya
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
HIV Antiretroviral Therapy (ART) Adherence, PMTCT
Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania
The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies.
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, PMTCT, Pregnancy, Retention in Care
- Trial name
- ENGAGE (NCT06605053)
- Testing
- Co-produced intervention to optimize PMTCT care engagement
- Where
- 2 sites in Tanzania
- Volunteers
- 222 people
- Sponsor
- Karolinska Institutet
mHealth, PMTCT
Mobile Strategies for Women's and Children's Health: Optimizing Adherence and Efficacy of PMTCT/ART
The investigators are conducting a 3-arm randomized trial comparing the effects of unidirectional SMS (ie: "push" messaging to participant) vs. bidirectional SMS dialogue between participant and provider vs.
- Conditions
- mHealth, PMTCT, Adherence, Medication, SMS
- Trial name
- Mobile WAChx (NCT02400671)
- Testing
- SMS messaging
- Where
- 6 sites in Kenya
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV-1
Prevention of Mother-to-child Transmission of HIV-1 Using a Responsive Intervention
The second visit of the Expanded Programme of Immunization when the child is 2 months old (EPI-2) represents a unique opportunity to link the EPI and PMTCT programmes and to introduce preventive and therapeutic rescue…
- Trial name
- PROMISE-EPI (NCT03870438)
- Testing
- Lamivudine Oral Solution
- Where
- 6 sites in Burkina Faso, Zambia
- Volunteers
- 1,506 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Pharmacokinetics Study on Nevirapine Resistance in Tanzania
Primary pharmacokinetics of single dose nevirapine the effect of single dose carbamazepine on the pk of single dose nevirapine resistance against nevirapine before and after.
- Trial name
- NCT00294892
- Testing
- carbamazepine and nevirapine, Nevirapine
- Where
- Tanzania
- Volunteers
- 144 people
- Sponsor
- Radboud University Medical Center
HIV Infections, Pregnancy
Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in Thailand
The purpose of this study is to compare the efficacy of two doses of nevirapine (NVP) given only to the infants or lopinavir/ritonavir (LPV/r) from 28 weeks gestation with single dose (SD) NVP given to the mothers plus two doses…
- Trial name
- PHPT-5 (NCT00409591)
- Testing
- Maternal and infant nevirapine, Maternal lopinavir+ritonavir, zidovudine
- Where
- 43 sites in Thailand
- Volunteers
- 435 people
- Sponsor
- Institut de Recherche pour le Developpement
HIV
Validation of a Community Survey Methodology for Measuring PMTCT Program Impact
Validate a promising community survey methodology for evaluating the Prevention of Mother to Child Transmission (PMTCT) program effectiveness against a "gold standard" cohort design and to identify individual- and facility-level…
- Trial name
- NCT01951794
- Where
- Zambia
- Volunteers
- 827 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Depression
Support for Perinatal Adherence and Depression
The main aim was to conduct a pilot field test of a group-based depression and adherence counseling intervention with HIV-infected women in the perinatal period.
- Trial name
- INSPireD (NCT03069417)
- Testing
- Integrating Nuanced Support for Perinatal adherence and Depression
- Where
- 2 sites in United States, South Africa
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Hepatitis B, Tenofovir
Tenofovir in Pregnancy to Prevent Mother to Child Transmission of Hepatitis B.
Hepatitis B virus (HBV) can be asymptomatic for years but can also lead to chronic hepatitis, hepatocellular carcinoma, and liver failure and death and cannot be eradicated with the current therapy.
- Conditions
- Hepatitis B, Tenofovir, Pregnancy
- Trial name
- PK-TDF (NCT04114890)
- Testing
- Tenofovir Disoproxil Fumarate
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- University of Oxford
HIV, Syphilis
Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique
The general goal of the proposed study is to evaluate the cost-effectiveness of POC technologies for diagnosis of syphilis, quantitative analysis for hemoglobin and CD4 counting performed within MCH services to improve maternal…
- Conditions
- HIV, Syphilis, Anemia During Pregnancy
- Trial name
- NCT02191527
- Testing
- PIMA® for quantitative analysis of CD4-count, Hemocue® (HemoCue AB, Angelhom, Sweden) for quantitative analysis of hemoglobin, SD Bioline® (Standard Diagnostics Inc., South-Korea) for qualitative analysis of syphilis
- Volunteers
- 1,673 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV, AIDS
Supporting Attendance for Facility Delivery and Infant Health
The goal of this proposed intervention study is to increase the proportion of HIV positive and HIV negative pregnant women who deliver in a facility, the proportion of HIV exposed infants (HEI) who receive nevirapine (NVP) within…
- Trial name
- SAFI (NCT03023033)
- Testing
- mHealth messaging, Transport Payments
- Where
- Tanzania
- Volunteers
- 1,505 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV/AIDS
Swaziland HIV Incidence Measurement Survey 2
The second Swaziland HIV Incidence Measurement Survey (SHIMS 2, 2016), is a population based HIV Impact Assessment (PHIA) that will assess the prevalence of key human immunodeficiency virus (HIV)-related health indicators.
- Trial name
- SHIMS2 (NCT04117984)
- Where
- Eswatini
- Volunteers
- 15,429 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infections, Acquired Immunodeficiency Syndrome
Improving Uptake of Early Infant Diagnosis of HIV for the Prevention of Mother-to-child Transmission of HIV
Early accurate diagnosis is one of the first crucial steps in care for infants born to HIV-infected mothers. Early initiation of antiretroviral therapy (ART) relies upon early diagnosis and results in significant reductions in…
- Trial name
- SMS4PMTCT (NCT01433185)
- Testing
- Text message
- Where
- Kenya
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Study of Cell Phone SMS Messages for Prevention of Maternal to Child Transmission of HIV
Optimal development of sustainable health systems must use locally relevant infrastructure. Mobile phone technology, driven primarily by local market forces rather than foreign assistance, is spreading rapidly through African…
- Trial name
- NCT01157442
- Testing
- cell phone sms text messaging
- Where
- Kenya
- Volunteers
- 856 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Human Immunodeficiency Virus
Friends for Life Circles for Option B Plus
The main goal of the study is to support HIV-infected pregnant women initiated on PMTCT Option B+ during antenatal to adhere to lifelong ART and postpartum care visits through an enhanced group peer support intervention called…
- Trial name
- FLCs (NCT02515370)
- Testing
- Friends for Life Circles (FLCs).
- Where
- Uganda
- Volunteers
- 540 people
- Sponsor
- MU-JHU CARE
HIV
Adapting the HITSystem to Support Prevention of Mother-to-child HIV Transmission
The purpose of this study is to modify the HITSystem to engage and retain HIV+ pregnant women before, during and after delivery and evaluate the HITSystem impact on prevention of mother-to-child transmission (PMTCT) related…
- Trial name
- NCT02726607
- Testing
- HIV Infant Tracking System (HITSystem) 2.0, Standard of PMTCT care
- Where
- 3 sites in United States, Kenya
- Volunteers
- 157 people
- Sponsor
- University of Kansas Medical Center
Retention
Lafiyan Jikin Mata "Excellent Health for Mothers"
This study aims to address the research question: Will continuous quality improvement, using a Break Through Series approach, increase uptake of PMTCT services and retention-in-care of HIV-infected pregnant women and mothers at…
- Trial name
- LJM (NCT02214875)
- Testing
- CQI/BTS, Control
- Where
- Nigeria
- Volunteers
- 491 people
- Sponsor
- Centre for Integrated Health Programs, Nigeria
HIV
Male Engagement in PMTCT Services
The study employs a quasi-experimental design in 8 public health centers in southwest Uganda offering care and treatment (C\&T) services.
- Trial name
- NCT01903889
- Testing
- clinic based intervention, clinic and community based intervention
- Where
- 7 sites in Uganda
- Volunteers
- 3,806 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV/AIDS
VITAL Start: Brief Facility-based Video Intervention
This a multi-center, parallel group, randomized controlled outcome assessor blinded trial with a qualitative descriptive component that seeks to assess the effectiveness of a brief facility-based video intervention to optimize…
- Trial name
- VITAL (NCT03654898)
- Testing
- VITAL Start: Video-based pre-ART counseling, Standard of Care
- Where
- Malawi
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine