Clinical trials: PERIODONTAL DISEASE
Chronic Periodontitis
Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
Modified perforated membrane (MPM) is considered as a modality that could enable participation of periosteal cells and gingival stem cells which could improve the outcomes of guided tissue regeneration more than the use of the…
- Trial name
- NCT03419429
- Testing
- Simvastatin, EDTA, Occlusive membrane
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Periodontitis, Intimal Medial Thickness of Internal Carotid Artery
PERIODONTITIS AND VASCULAR DYSFUNCTION
The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point…
- Trial name
- NCT03072342
- Testing
- Intensive Periodontal Treatment, Control Periodontal Treatment
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University College, London
Gingival Recession, Generalized
Adjunctive Use of Hyaluronic Acid in Multiple Coronally Advanced Flap
The primary aim of this study is to evaluate whether the effect of HA in combination with XCM for the treatment of MAGRs with a multiple coronally advanced flap technique (mCAF) achieves better results than the XCM with mCAF…
- Trial name
- NCT05370456
- Testing
- Local application of a HA gel for the treatment of MAGRs with mCAF technique and XCM, Treatment of MAGRs with mCAF technique and XCM
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Pain, Quality of Life
Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life
Pericoronitis is a painful inflammatory condition which is well known for its negative impact on quality of life of those affected.
- Trial name
- NCT03745599
- Testing
- Diclofenac, Flurbiprofen, Benzydamine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Near East University, Turkey
Peri-implantitis, Soft Tissue Augmentation at Dental Implants
Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis
This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive…
- Trial name
- NCT07471386
- Testing
- Submucosal debridman + saline irrigation, Free gingival graft surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Coronariopathy
Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies
Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization.
- Trial name
- NCT02150005
- Testing
- Periodontal treatment
- Volunteers
- 22 people
- Sponsor
- Universidade Veiga de Almeida
Myocardial Infarction, Chronic Periodontitis
The Effect of Periodontal Therapy in Chronic Periodontitis Patients With and Without Acute Myocardial Infarction
The aim of this study was to evaluate the effects of periodontal treatment on gingival crevicular fluid (GCF) levels of Neopterin(N) and vascular cell adhesion molecule (VCAM-1) in chronic periodontitis(CP) patients with acute…
- Trial name
- NCT03005886
- Testing
- Periodontal examination, GCF sampling, phase I therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Pulp Necrosis, Apical Periodontitis
CGF-Enhanced Autologous Pulp Transplantation in Mature Necrotic Teeth
This pilot clinical study evaluated the clinical, radiographic, and functional outcomes of autologous pulp transplantation combined with concentrated growth factor (CGF) in mature permanent teeth with pulp necrosis and periapical…
- Trial name
- CGF-PULP (NCT07314866)
- Testing
- Autologous Pulp Transplantation With Concentrated Growth Factor
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Apical Periodontitis
Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated…
- Trial name
- NCT07856186
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Alveolar Bone Loss
Novel Photosensitizer in The Treatment of Chronic Periodontitis
The aim of this study is to evaluate the periodontal outcomes after applying antimicrobial photodynamic therapy with a novel photosensitizer as compared to LASER assisted scaling and root planing alone.
- Trial name
- NCT04374383
- Testing
- Phthalocyanine Dye, LASER assisted SRP
- Where
- 2 sites in India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Gingival Recession, Non-Carious Cervical Lesions (NCCLs)
Root Coverage Performance of Restorative Materials in Class V Cavities
This prospective randomized controlled clinical trial aims to evaluate the influence of different restorative materials placed in Class V cervical lesions on the clinical outcomes of root coverage surgery using a subepithelial…
- Trial name
- NCT07687654
- Testing
- No Restoration Control Group, Glass Ionomer Cement Group, Resin Composite Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zeliha Başak Çakır Erdil
Alveolar Bone Loss
Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Alveolar Ridge Preservation
With alveolar ridge preservation (ARP) ridge resorption following extraction may be reduced. Several materials and techniques have been advocated for ARP.
- Trial name
- NCT05674331
- Testing
- Extraction site development technique, autogenous tooth bone graft, Socket seal technique
- Where
- Hungary
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Necrotic Pulp With Symptomatic Apical Periodontitis
The Impact of Using Different Final Irrigation Modes on Postoperative Pain Following Root Canal Treatment of Non-vital Mandibular First Molar With Periapical Lesion.
The goal of this clinical trial is to learn which rinsing of root canals method works best to lower pain after a root canal in adults.
- Trial name
- NCT07623629
- Testing
- root canal treatment
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Maxillary Deficiency, Alveolar Bone Loss
Completely Versus Partially Guided Zygomatic Implant
The aim of study is evaluation of accuracy of completely versus partially limiting computer generated surgical three-dimensional guides during placement of zygoma implants in patients with atrophic maxillae.
- Trial name
- NCT06227351
- Testing
- completely limiting computer generated surgical three-dimensional guide, Partially limiting computer generated surgical three-dimensional guide
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Fayoum University
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontitis
Efficacy of Adjunctive Antimicrobial Photodynamic Therapy for Residual Pockets in Previously Surgically Treated Teeth
Traditionally, periodontal gum surgery has been used as a method to gain access to inflamed periodontal pockets around teeth. The outcome of these surgeries, however, is not always successful as there can be recurrence of…
- Trial name
- NCT03757260
- Testing
- Antimicrobial photodynamic therapy
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontal Pocket
Periodontal Tissue Regeneration Using Autologous Periodontal Ligament Stem Cells
The purpose of this clinical trial is to both clarify the efficiency of autologous periodontal ligament (PDL) stem cells to regenerate periodontal tissue in periodontitis patients with deep intraosseous defects (>5 mm) and to…
- Trial name
- PDLSC (NCT01357785)
- Testing
- Cell therapy
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Air Force Military Medical University, China
Endodontic Disease, Periapical Diseases
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
Introduction: In the US, 15 million root canal treatments (RCTs) are carried out annually. Success rates decrease with conventional chemo-mechanical root canal preparation techniques used on teeth with periapical radiolucencies…
- Conditions
- Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
- Trial name
- NCT05555043
- Testing
- Irrisafe ip, GentleWave System, Waterlase iPlus
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Peri-Implantitis
Treatment of Mild to Moderate Peri-implantitis Using an Oscillating Chitosan Device
34 patients diagnosed with mild to moderate peri-implantitis, defined as 2-4 mm peri-implant bone loss, will be randomized to either test treatment with Labrida BioClean® or control treatment with titanium curettes.
- Trial name
- NCT03373448
- Testing
- Labrida BioClean, Titanium curettes
- Where
- 5 sites in Norway, Sweden
- Volunteers
- 34 people
- Sponsor
- Labrida AS