Clinical trials: PERIODONTAL DISEASE
Metabolic Disease
Evaluation of Malondialdehyde in Periodontal and Cardiovascular Disease
Malondialdehyde (MDA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD).
- Trial name
- NCT04030286
- Testing
- Observation
- Where
- Italy
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Messina
Alveolar Bone Loss, Bone Deformity
Influence of Mandibular Nerve Lateralization on Nutrition and Speech
This study aimed to evaluate the effects of lip numbness on the nutritional status and speech of patients who underwent inferior nerve lateralization for dental implant placement in the mandibular posterior region.
- Trial name
- NCT05659069
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Periodontitis, Chronic, Chewing Problem
Assessment of Masticatory Performance in Periodontitis
The loss of periodontal attachment contributes to reduced masticatory performance and has a negative impact on general health.This clinical trial aims to assess the status of masticatory performance among patients with stage I…
- Conditions
- Periodontitis, Chronic, Chewing Problem, Inflammation
- Trial name
- NCT06426069
- Testing
- Masticatory efficiency assessment
- Where
- India
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Primary Apical Periodontitis, Root Canal Infection
Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR
This pilot randomized clinical study aims to compare bacterial profiles in symptomatic and asymptomatic primary apical periodontitis using 16S rRNA polymerase chain reaction sequencing.
- Conditions
- Primary Apical Periodontitis, Root Canal Infection, Endodontic Infection
- Trial name
- NCT07637305
- Testing
- 3% Sodium Hypochlorite Irrigation with Ultrasonic Activation, 5.25% Sodium Hypochlorite Irrigation with Ultrasonic Activation
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Smoking ( Cigarette), Smoking (Tobacco) Addiction
Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life
Tobacco smoking remains one of the leading preventable causes of disease, disability, and premature death worldwide. According to the World Health Organization, tobacco use is responsible for more than eight million deaths each…
- Conditions
- Smoking ( Cigarette), Smoking (Tobacco) Addiction, Smoking Behaviors, Smoking Cessation
- Trial name
- Wear-Smile (NCT07593742)
- Testing
- Telemedicine-Based Smoking Cessation Program, Conventional Smoking Cessation Behavioral Program
- Volunteers
- 102 people
- Sponsor
- University of Salerno
Periodontitis
Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy
Study Hypothesis: The administration of 200 mg doxycycline once a day for 7 days after regenerative periodontal therapy of infrabony defects improves the results of therapy (clinical vertical attachment gains [CAL-V], bony fill)…
- Trial name
- GTRDOXY (NCT01030666)
- Testing
- Doxycycline, modified/simplified papilla preservation flap; scaling, Prefgel/Emdogain
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Peter Eickholz
Periodontal Disease, Non-diseased Patients
The Importance of Periostin in Periodontal Health and Disease
The goal of this study is to determine the clinical importance of Periostin in oral health and disease. The long-term goal will be to develop practical applications for the diagnosis, treatment, prevention and cure of human…
- Trial name
- NCT01180920
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Furcation Defects
Effect of Two Irrigation Protocols Applied Prior to Furcation Repair
Perforations are mishaps that might occur during the course of endodontic treatment mainly due to iatrogenic factors. However, they might also occur due to extensive decay of dentinal structure.
- Trial name
- NCT06757660
- Testing
- Furcation Repair
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Periodontal Disease, Periodontal Attachment Loss
Study on Regenerative Treatment of Intra-bony Defects
The aim of this investigation is to determine whether a synthetic hydroxyapatite is as effective as an enamel matrix protein for periodontal regeneration in patients who have intra-bony periodontal defects.
- Trial name
- NCT00757159
- Testing
- Ostim, Emdogain
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Technische Universität Dresden
Calculus, Dental, Periodontal Diseases
Development of a New Toothpaste for the Removal of Dental Calculus.
Periodontal disease is amongst the most prevalent oral diseases worldwide and in North America. According to the 2007/09 Canadian Health Measures Survey, 16% of Canadian adults and 24% of older adults, 60 to 79 years of age, were…
- Conditions
- Calculus, Dental, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04381403
- Testing
- Bio-descaling D-Tart toothpaste, Crest® toothpaste
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Faleh Tamimi
Gingival Recession, Localized
Gingival Response and Marginal Adaptation of Zirconia Crowns With Two Subgingival Margin Designs
The aim of the study is to evaluate the effect of feather edge finish line and deep chamfer finish line on gingival position, bleeding on probing and marginal adaptation.
- Trial name
- NCT04729569
- Testing
- Feather edge finish line preparation, Deep chamfer finish line preparation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heart Transplant Failure, Periodontitis
Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients
Inflammation plays a key role in the deterioration of chronic heart transplants. Periodontal disease is not limited to the tooth-supporting structures - it also contributes to systemic inflammation.
- Conditions
- Heart Transplant Failure, Periodontitis, Crp
- Trial name
- NCT03671408
- Testing
- clinical measurements
- Volunteers
- 33 people
- Sponsor
- Baskent University
Chronic Periodontitis
Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients
The objective of this study is to evaluate of ozone therapy on both clinical and biochemical effects in periodontally patients.
- Trial name
- NCT03874390
- Testing
- ozone
- Volunteers
- 50 people
- Sponsor
- Ataturk University
Periodontitis
Air Polishing for Pain and Compliance in Supportive Periodontal Therapy
Supportive periodontal therapy (SPT) is essential for maintaining periodontal stability and preventing disease recurrence in patients who have been successfully treated for periodontitis.
- Trial name
- NCT07837947
- Testing
- Trehalose Air-Polishing, Ultrasonic Instrumentation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Octavi Camps-Font
Gingival Recession
Mechanisms of LPRF Action in the Promotion of Wound Healing and Tissue Regeneration
This study evaluates the clinical and biological effects of leucocyte and platelet-rich fibrin (L-PRF) on intraoral wound healing.
- Trial name
- NCT03992638
- Testing
- leucocyte and platelet-rich fibrin (L-PRF) in combination with CAF, CAF
- Where
- Hong Kong
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The European Research Group on Periodontology (ERGOPerio)
Gingival Recession, Connective Tissue Defect
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics.
- Trial name
- FibroGide (NCT07437417)
- Testing
- Volume stable collagen matrix, Control
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Periodontal Diseases
Periodontal Health and Sodium Bicarbonate Toothpaste
The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment.
- Trial name
- NCT07274189
- Testing
- no treatment received, Periodontal treatment and OHI
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Plymouth
Microbial Colonization, Periodontal Diseases
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Periodontitis is an inflammatory disease characterized by a dysbiotic microbiome which can lead to bone destruction and tooth loss.
- Conditions
- Microbial Colonization, Periodontal Diseases, Periodontal Inflammation
- Trial name
- NCT04580355
- Testing
- One-Stage Full Mouth Debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Chronic Periodontitis, Cardiovascular Diseases
NSPT On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease
Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation…
- Conditions
- Chronic Periodontitis, Cardiovascular Diseases, Periodontal Inflammation
- Trial name
- NCT05663476
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Endodontically Treated Teeth, Endodontic Underfill
No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Treatment
Developing neural network-based models for image analysis can be time-consuming, requiring dataset design and model training. No-code AI platforms allow users to annotate object features without coding.
- Conditions
- Endodontically Treated Teeth, Endodontic Underfill, Endodontic Overfill, Apical Periodontitis
- Trial name
- NCT06450938
- Testing
- AI guidance for finding radiographic features
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen