Clinical trials: PERIODONTAL DISEASE
Gingival Recession, Mucogingival Deformity - Insufficient Keratinized Tissue
Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage
This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from…
- Trial name
- NCT07590960
- Testing
- Modified Coronally Advanced Tunnel with Connective Tissue Graft
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Dental Implant Failed, Implant Complication
Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?
The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs.
- Conditions
- Dental Implant Failed, Implant Complication, Implant Site Infection, Implant Site Reaction
- Trial name
- NCT06515886
- Testing
- Clinical Examination, Peri-implant crevicular fluid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Edentulous Alveolar Ridge, Peri-Implantitis
Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry
The goal of this clinical trial is to learn how different materials used in dental implants affect the surrounding gum tissue in adults who need dental implants.
- Conditions
- Edentulous Alveolar Ridge, Peri-Implantitis, Peri-implant Mucositis, Prosthetic Infection
- Trial name
- NCT06554041
- Testing
- Dental Crown with Titanium-Abutment, Dental Crown with PEEK (Polyetheretherketone)-Abutment, Dental Crown with Zirconia-Abutment
- Where
- Lithuania
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Periodontitis
Air Polishing as an Adjunct in Non-surgical Periodontal Therapy
Periodontal disease is an infection that causes inflammation and destruction of the tooth supporting structures, and if untreated, will eventually lead to tooth loss.
- Trial name
- NCT04178291
- Testing
- Ultrasonic scaler and Gracey currettes, Air polishing with erythritol powder
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Gingival Recession
The Tunnel Technique and Free Gingival Graft in Gingival Recessions Treatment
The present study aims to compare the tunnel technique/laterally closed tunnel technique and the FGG technique in the treatment of isolate/multiple GR in the anterior region of the mandible.
- Trial name
- NCT05270161
- Testing
- Tunnel technique, Laterally closed tunnel technique, Free gingival graft
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Alfenas
Gingivitis, Periodontal Diseases
Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents
Introduction: This study aims to evaluate the gingivitis, periodontal profile and malocclusion in children and adolescents with diabetes.
- Conditions
- Gingivitis, Periodontal Diseases, Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT06291129
- Testing
- Periodontal therapy
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Gingival Inflammation and Loss the Orthodontic Mini-screws
Strontium-Hydroxyapatite Coated Mini-Screws: Antibacterial Effect and Stability
This randomized controlled clinical trial aims to evaluate the antibacterial efficacy and stability of strontium-incorporated hydroxyapatite (Sr-HA) coated orthodontic mini-screws (OMSs) used for maxillary canine retraction.
- Trial name
- NCT07105969
- Testing
- Strontium Incorporated Hydroxyapatite [Sr-HA] coated mini-screws purchased from Dentarum company
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis, Diabetes Mellitus, Type 2
A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities
The project (PlanPerioMed) is a register-based study evaluating the associations and patterns of health care delivery between periodontitis and medical diseases using data from the Danish dental record system Dentalsuite…
- Conditions
- Periodontitis, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Rheumatoid Arthritis
- Trial name
- PlanPerioMed (NCT05574231)
- Testing
- Periodontal treatment
- Volunteers
- 4,000,000 people
- Sponsor
- University of Copenhagen
Periodontal Diseases
Enamel Matrix Derivatives on Systemic Inflammation After Periodontal Therapy
The aim of this study is to compare periodontal treatment with or without the adjunct of an enamel matrix derivative in terms of acute-phase responses in healthy patients.
- Trial name
- PERIOEMD-2 (NCT03544931)
- Testing
- Root Instrumentation, EMD Application
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Pisa
Alveolar Bone Loss* / Therapy
Study on Silk Fibroin-Reinforced Collagen-Based Composite Membrane for Periodontal Bone Tissue Regeneration
Based on the mechanism of intramembranous ossification of the alveolar bone, it is necessary to design a biomimetic membrane material based on the principle of GBR (Guided Bone Regeneration) to simulate the biological…
- Trial name
- NCT07574853
- Testing
- Silk Fibroin-Reinforced Collagen-Based Composite Membrane
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Periodontal Diseases
Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome
Emerging research indicates a link between polycystic ovary syndrome (PCOS) and periodontal diseases, revealing the intricate relationship between oral health and systemic conditions.
- Trial name
- NCT06184412
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Gingival Recession
Treatment of Multiple Gingival Recessions With a MCAF or a MCAT and a Collagen Matrix
In a recent meta-analysis, Graziani et al. reported that despite the "ideal" treatment for multiple gingival recession defects is not yet identified, there are some indirect suggestions from the analyzed data that, in comparison…
- Trial name
- NCT04225351
- Testing
- MCAF+CM, MCAT+CM
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Juvenile Idiopathic Arthritis, Gingivitis
Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively…
- Conditions
- Juvenile Idiopathic Arthritis, Gingivitis, Decay, Dental
- Trial name
- NCT05217277
- Testing
- Humans ELISA kits
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Marmara University
Alzheimer Disease, Periodontal Diseases
Investigation of Alzheimer's Disease and Periodontal Status
The aim of this study is to investigate the effect of the current periodontal status on the progression rate of AD.
- Trial name
- NCT05807100
- Testing
- Baseline Standardized Mini Mental Test, 6th month Standardized Mini Mental Test
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bezmialem Vakif University
Periodontal Pocket
Treatment of Periodontal Intraosseous Defects
The aim of the present study was to evaluate the impact of surgical flap design on the healing of intrabony defects treated by means periodontal regeneration. Forty patients were enrolled and allocated random in two groups.
- Trial name
- NCT04542746
- Testing
- Minimally invasive surgical technique
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Iorio Research and Dental Practice
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes
This randomized controlled clinical trial aims to evaluate the effectiveness of a para-probiotic-based oral care protocol in improving periodontal health and glycemic control in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- PPDM2 (NCT07069166)
- Testing
- Para-probiotic oral care, Chlorhexidine oral care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Periodontitis
Comparison of Subgingival Mechanotherapy With and Without the Use of a Perioscope: Clinical Trial
The study aims to comparatively assess clinical parameters, biochemical and microbiological parameters after treatment of periodontitis using subgingival mechanotherapy traditional and subgingival mechanotherapy using a…
- Trial name
- NCT06366295
- Testing
- subgingival mechanotherapy with perioscopy, classical subgingival mechanotherapy
- Where
- Poland
- Volunteers
- 26 people
- Sponsor
- Medical University of Warsaw
Orthodontics, Dental Hygiene
Evaluation of the Effect of a Probiotic in Patients Undergoing Orthodontic Therapy
Orthodontic patients need supplementary oral hygiene tools in addition to professional oral hygiene. The aim of this study is to evaluate the effects of Bifidobacterium animalis subs.
- Conditions
- Orthodontics, Dental Hygiene, Gingivitis and Periodontal Diseases
- Trial name
- NCT06752330
- Testing
- Use of probiotics during oral hygiene at home
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Alveolar Bone Loss
Autogenous Demineralized Dentin Block Graft Versus Particulate Deproteinized Bovine Bone Graft for Alveolar Ridge Preservation
The aim of this trial is to compare the effect of autogenous demineralized dentin block graft (ADDBG) versus particulate deproteinized bovine bone graft (PDBBG) on alveolar ridge preservation after extraction of non-restorable…
- Trial name
- NCT05374083
- Testing
- Alveolar ridge preservation using autogenous demineralized dentin block graft, Alveolar ridge preservation using particulate deproteinized bovine bone graft
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University