Clinical trials: PERIODONTAL DISEASE
Gingival Recession
Evaluation of Root Coverage After the Use of Coronally Advanced Flap Either With Advanced Paltelet Rich Fibrin or Subepithilial Connective Tissue Graft in Treatment of Miller Class I and II Gingival Recession.
patients with Miller class I , II gingival recession will be divided into 2 groups (control, intervention).the control one will receive coronally advanced flap with subepithililal connective tissue graft harvested from the palate…
- Trial name
- NCT03695549
- Testing
- CAF + (A-PRF), CAF+SCTG
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Periodontitis
Perio. Maint. With Diode LBR
The primary aim of this pilot study is to determine whether the test methods described feasibly achieve the goal defined for a future clinical study.
- Trial name
- NCT05276817
- Testing
- Epic Diode, HP
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Biolase Inc
Periodontal Diseases, Aggressive Periodontitis
Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.
Treatment of smoker patients with AgP is considered a challenge to periodontists. To date, only one controlled clinical study (De Genaro Modanese et al., 2016) evaluated the effect of full mouth ultrasonic debridment (FMUD) on…
- Trial name
- NCT04051255
- Testing
- full mouth ultrassonic debridement associated to Amoxicilin 500 + Metronidazole 400 mg
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontal Disease, Chronic Periodontitis (Disorder)
Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response
Periodontitis (gum inflammation) is a common disease worldwide. This study aims to investigate a novel biomarker, a protein called Mitofusin-1 (Mfn1), in saliva that may be associated with the severity of periodontitis and…
- Trial name
- NCT07262606
- Testing
- Non-surgical Periodontal Therapy (Scaling and Root Planing), Saliva Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Periodontitis, Dry Eye Disease (DED)
Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study
This study is aiming at exploring the association between periodontitis and dry eye disease, which are both chronic inflammatory diseases that might have common pathogenic mechanisms.
- Trial name
- NCT07873697
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Periodontitis, Gingivitis
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need.
- Trial name
- NCT06135116
- Testing
- Flow Cytometric Detection of Regulatory T Cells and Cytokines analysis by ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Missing Teeth, Edentulous Alveolar Ridge
Hybrid Funnel Technique a Innovative Technique for Implant Site Preparation
Hybrid Funnel Technique arises from the union of subtractive and non-subtractive techniques for implant site preparation. Hybrid funnel technique is performed with specially designed drills and osteotome.
- Conditions
- Missing Teeth, Edentulous Alveolar Ridge, Tooth Loss
- Trial name
- NCT05499533
- Testing
- implant site preparation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Luigi Canullo
Gingival Recession
Evaluation of Cyanoacrylate as an Alternative to Sutures in Free Gingival Graft Stabilization
Free gingival graft (FGG) is a widely used periodontal plastic surgery technique for treating gingival recession, increasing keratinized gingiva width, and enhancing peri-implant soft tissues.
- Trial name
- NCT06821984
- Testing
- FGG secured using cyanoacrylate tissue adhesive without sutures.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Gingival Recession
MCAF and EMD With and Without CTG Wall Technique for the Treatment of Class III and IV Gingival recessions-a Randomized Control Trial
Research is to compare and evaluate the clinical outcomes of the Connective tissue graft wall technique with modified coronally advanced flap to improve root coverage and clinical attachment levels in Miller's class III and IV…
- Trial name
- NCT06525285
- Testing
- Connective tissue graft wall technique
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Pocket, Impacted Third Molar Tooth
Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery
This study evaluates the effectiveness of using Mineralized Plasmatic Matrix and β-tricalcium phosphate that placed to extraction socket as a graft material in terms of periodontal damage occurred in the distal aspect of the…
- Conditions
- Periodontal Pocket, Impacted Third Molar Tooth, Impacted Teeth With Abnormal Position
- Trial name
- NCT04366635
- Testing
- Impacted third molar surgery, Application of mineralised plasmatic matrix, Application of β-tricalcium phosphate
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Peri-Implantitis, Periodontitis
Macrophage Markers in Periodontal and Peri-implant Health and Disease
Macrophage surface markers (CD80, CD163 and CD206) will be evaluated in periodontally healthy gingiva, healthy peri-implant mucosa, and periodontitis and peri-implantitis lesions.
- Trial name
- NCT05242354
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontitis
The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health
Investigate the influence of the crown tye Porcelain fused to metal or Zirconia on periodontal health.
- Trial name
- NCT02461823
- Testing
- Zirconia crown, Porcelain metal crown
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Smoking and dual using associated with poor periodontal health.
- Trial name
- NCT03918902
- Testing
- Qestinnaires
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Apical Periodontitis
Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing
The aim of this study is to compare the effect of passive ultrasonic irrigation versus needle irrigation on post-operative pain and healing in patients with permanent posterior teeth with apical periodontitis treated in a single…
- Trial name
- NCT02913937
- Testing
- Passive ultrasonic irrigation, Endodontic needle
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis (Stage 3), Smoking
Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients
This study looked at whether a type of gum disease called Stage III periodontitis and cigarette smoking are linked to higher levels of "oxidative stress." Oxidative stress can damage DNA and RNA, which are important parts of our…
- Trial name
- NCT07279896
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Peri-implantitis, Soft Tissue Augmentation at Dental Implants
Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis
This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive…
- Trial name
- NCT07471386
- Testing
- Submucosal debridman + saline irrigation, Free gingival graft surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Type 2 Diabetes Mellitus
Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic
The purpose of the study was to monitor the activity of periodontal disease and suggest potential biomarkers related to active periodontal disease in patients with chronic periodontitis (PD) associated or not with type 2 diabetes…
- Trial name
- NCT02220751
- Testing
- non-surgical periodontal therapy + systemic doxycycline, Non-surgical periodontal therapy
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Deep Caries, Dental Caries
Evaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation
This study will be conducted to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer compared to nanohybrid resin composite restoration in deep subgingival proximal cavities extending below the CEJ…
- Trial name
- NCT06497231
- Testing
- Beautifil II LS, Nanohybrid resin composite material
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
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