Clinical trials: PCOS (Polycystic Ovary Syndrome)
Polycystic Ovary Syndrome (PCOS) Women
Health-related Quality of Life of Women with Polycystic Ovary Syndrome At Sohag University Hospital
It is well-established that PCOS women suffer from anxiety, depression, and markedly reduced QoL ,but There has not yet been a nationally representative study to evaluate the PCOS health related Qol and factors affecting it among…
- Trial name
- NCT06832735
- Where
- Egypt
- Volunteers
- 352 people
- Sponsor
- Sohag University
Infertility Treatment, Pregnancy Rates
Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate
Women who meet the study requirements will be enrolled and randomly assigned by a computer system to receive either pioglitazone 30 mg daily or a placebo starting from the second day of their menstrual period for the same…
- Trial name
- NCT07462065
- Testing
- Clomiphene Citrate., Pioglitazone (PIO) + Clomiphene citrate
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- PAEC General Hospital, Islamabad
Polycystic Ovary Syndrome
A Multi-omic Approach to Evaluate and Characterize the Polycystic Ovary Syndrome (PCOS) Phenotype
The purpose of this research study is to explore the relationship between the gut microbiome and hormone levels in women diagnosed with PCOS and determine whether there are differences in the gut microbiome between women with…
- Trial name
- NCT04981275
- Testing
- No intervention study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Onegevity Health
Polycystic Ovary Syndrome
Clinical and Biochemical Presentation of Polycystic Ovary Syndrome in Different Age Group
To study the clinical and biochemical characteristics women with polycystic ovary syndrome (PCOS) in different aged groups.
- Trial name
- NCT01350895
- Where
- Taiwan
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Polycystic Ovarian Syndrome in Adolescent Females, Obesity (Disorder)
Effects of Glucagon-like Peptide-1 (GLP-1) Agonist in Neuro-reproductive Function in Obese Adolescent Females With Polycystic Ovary Syndrome (PCOS)
The prevalence of childhood obesity in the United States has more than tripled in the past four decades affecting one in every five adolescent girls and is disproportionally higher among racial and/or ethnic minorities.
- Trial name
- NCT07169136
- Testing
- GLP-1 Receptor Agonists
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Polycystic Ovary Syndrome
Improved Effects of MI Plus Alpha-LA in PCOS
PCOS patients are initially treated with 2 g myo-inositol and 0.2 mg folic acid, two times per day by oral route, for three months.
- Trial name
- NCT03422289
- Testing
- myo-inositol plus folic acid, myo-inositol plus folic acid plus alpha-lactalbumin
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Lo.Li.Pharma s.r.l
Polycystic Ovarian Disease
The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing
Polycystic ovary syndrome is one of the most common causes of female infertility. The cause of infertility in PCOS is unknown. Factors other than anovulation, including inherited or induced changes in the embryo quality have been…
- Trial name
- PCOS (NCT01953146)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome
Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole
Aromatase inhibitors such as letrozole are hypothesized to maintain normal hypothalamic/ pituitary feedback mechanisms and in the case of OI (ovulation induction) in women with PCOS, may act to increase follicular sensitivity to…
- Trial name
- NCT03440359
- Testing
- Progesterone Vaginal Gel 8%, Letrozole Oral Tablet, pelvic ultrasound
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eastern Virginia Medical School
Polycystic Ovary Syndrome
Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH.
The purpose of this study is to evaluate the effect of increased circulating androgens on estradiol production by the granulosa cells in response to FSH stimulus.
- Trial name
- NCT02389088
- Testing
- Letrozole
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Polycystic Ovary Syndrome
The Role of Autoimmunity and Obesity in Polycystic Ovary Syndrome
The goal of the study is to detect autoantibodies in the serum of the women with PCOS and evaluate the obesity markers to investigate the the role of autoimmunity and obesity in PCOS
- Trial name
- NCT05929950
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal
PCOS
A Metabolomic Study of Polycystic Ovary Syndrome With Insulin Resistance and Its Relationship With TCM Syndrome Types
The type-2 diabetes mellitus（T2DM）, metabolic syndrome, cardiovascular disease complications induced by polycystic ovary syndrome(PCOS) with insulin resistance(IR）, which become serious threat to public health.
- Trial name
- NCT02992093
- Testing
- all the indicators
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Adverse Effects of Medical Drugs
Effects of Isotretinoin on The Gonads and Hirsutism
The investigators consider that there are some rising concerns about the use of isotretinoin by women of reproductive age with depleted ovarian reserve, hence it is important to detect the effect of isotretinoin on ovarian…
- Trial name
- NCT02855138
- Testing
- oral isotretinoin
- Volunteers
- 80 people
- Sponsor
- Kayseri Education and Research Hospital
Polycystic Ovary Syndrome, Obesity
Correlating Improvement in PCOS Symptoms to the Percentage of Body Weight Lost in Females Also Living With Obesity
The goal of this clinical trial is to study the effects of a intensive weight loss program (STREAM) in patients living with PCOS.
- Trial name
- FLOWERS-PCOS (NCT06325449)
- Testing
- STREAM program
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Polycystic Ovary Syndrome
IVF Outcome in Polycystic Ovary Syndrome Patients
1. To investigate the circulating concentrations of phoenixin and their associations with BMI, the concentrations of sex hormones including (LH), (FSH), (E2), (P4), (TT) and steroid hormones enzyme in PCOS patients. 2.
- Trial name
- NCT04104958
- Testing
- qRTPCR (mRNA level).
- Volunteers
- 100 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome, Obesity
Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study
The polycystic ovary syndrome is the leading cause of female infertility in the United States. The disorder affects approximately 6-10% of women of reproductive age.
- Trial name
- NCT00436865
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Polycystic Ovarian Syndrome, Obesity, Abdominal
Acupuncture in the Regulation of Dai Meridian for Polycystic Ovarian Syndrome Patients With Abdominal Obesity
The purpose of this study is to determine whether the use of electroacupuncture to dredge and regulate Dai Meridian combined with lifestyle modification are more effective than lifestyle modification only in the treatment of…
- Trial name
- NCT02785965
- Testing
- electroacupuncture, lifestyle modification
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Polycystic Ovarian Syndrome (PCOS), Insulin Resistance
Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation
A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Insulin Resistance, Overweight, Obese
- Trial name
- NCT02105428
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
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