Clinical trials: PCOS
Polycystic Ovary Syndrome (PCOS)
Low-Carb Versus Mediterranean Diet in PCOS
This is a randomized controlled trial of two diets (low-carbohydrate and Mediterranean diet) in the treatment of women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT05272657
- Testing
- low-carbohydrate diet, Mediterranean diet
- Volunteers
- 130 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Polycystic Ovarian Syndrome (PCOS)
Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study
In polycystic ovary syndrome (PCOS), changes in physical appearance i.e. weight gain, hirsutism, menstrual disturbances and infertility result in reduced quality-of-life.
- Trial name
- NCT07459595
- Testing
- Myoinositol, Metformin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Fatima Tariq
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, T2D
Study on the Efficacy and Safety of Chiglitazar Sodium in PCOS With T2DM
Purpose and significance: To explore the clinical efficacy and safety of Chiglitazar sodium in polycystic ovary syndrome with type 2 diabetes Methods: From October 2022 to September 2024, a total of 142 PCOS with T2DM patients…
- Trial name
- NCT05760677
- Testing
- pioglitazone group: lifestyle intervention+ metformin+ orlistat (obese patients)+ pioglitazone, the Chiglitazar group: lifestyle intervention+ metformin+ orlistat (obese patients)+ Chiglitazar
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Affiliated Hospital of Nantong University
Polycystic Ovary Syndrome
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)
PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies.
- Trial name
- PERCING (NCT00378729)
- Testing
- Metformin and FSHr, Ovarian drilling by FERTILOSCOPY
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis, Polycystic Ovary Syndrome
Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen
PCOS is a widely reported condition among young female population and anti-androgen agents are increasingly being used as part of the medical management of such cases.
- Conditions
- Periodontitis, Polycystic Ovary Syndrome, Gingivitis
- Trial name
- NCT05021861
- Testing
- Cyproterone Acetate, Ethinyl Estradiol Drug Combination, FEMALE PATIENTS WITH PCOS, Control group
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Polycystic Ovary Syndrome
A Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth in Women With PCOS
This study is a randomized assessor-blind controlled trial. A total of 1,103 women with PCOS will be recruited from 20 hospitals and randomly allocated into four groups: personalized acupuncture, fixed acupuncture, letrozole or…
- Trial name
- NCT03625531
- Testing
- Acupuncture, Letrozole
- Where
- China
- Volunteers
- 1,103 people
- Sponsor
- Hongxia Ma
Polycystic Ovary Syndrome, Normal Volunteers
Proteomics & Glyco-Proteomic Analysis of Follicular Fluid
To the best of the investigators knowledge, exhaustive characterization of the low and high abundant proteins and glyco-proteins of the Follicular Fluid (FF) has not yet been achieved.
- Trial name
- NCT01487486
- Testing
- IVF Antagonist Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Polycystic Ovary Syndrome
Novel Subtypes of Polycystic Ovary Syndrome
To classify subtypes of Polycystic Ovary Syndrome (PCOS) using machine-learning algorithms, and compare the reproductive and metabolic characteristics and IVF outcomes across these identified subtypes.
- Trial name
- NCT06124391
- Testing
- Long-term follow-up
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
PCOS
Insulin and Polycystic Ovary Syndrome
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women.
- Trial name
- NCT00683774
- Testing
- diazoxide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Polycystic Ovary Syndrome, Infertility, Female
Effect of Nitric Oxide Donors on Uterine and Subendometrial Blood Flow in Patients With Unexplained Infertility
The purpose of the study to evaluate effect of nitroglycerin trans-dermal patches on uterine and sub-endometrial blood flow in women with unexplained infertility.
- Trial name
- NCT03481582
- Testing
- Nitroglycerin, Three dimensional power doppler
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome
The Effect of Lifestyle Program Women With PCOS
Polycystic Ovary Syndrome (PCOS) is a common hormonal condition affecting women of reproductive age. In addition to physical symptoms such as irregular menstruation, hormonal changes, and changes in body weight, women with PCOS…
- Trial name
- PCOS (NCT07880366)
- Testing
- Lifestyle Modification Program (LMP)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Polycystic Ovary Syndrome, Insulin Resistance
Comparison of Alogliptin Versus Alogliptin and Pioglitazone on Insulin Resistance of Metformin Treated Women With PCOS
The purpose of this study was to determine whether dual treatment with metformin and alogliptin is more effective than treatment with metformin, alogliptin and pioglitazone in the treatment of obese women with polycystic ovary…
- Trial name
- NCT02683226
- Testing
- Vipdomet, Incresync
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Polycystic Ovary Syndrome
The Phenotype and Clinical Intervention of High BCAA Type of PCOS
Polycystic ovary syndrome is one of the main diseases leading to infertility in women of childbearing age. In addition to endocrine and reproductive dysfunction, it is often accompanied by significant metabolic abnormalities…
- Trial name
- BCAAPCOS (NCT06192147)
- Testing
- protein restricted diet combined with vitamin D intervention
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Polycystic Ovary Syndrome
Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Oral contraceptives are known to improve menstrual cycles and symptoms in PCOS, however may increase cholesterol. Metformin, a drug to improve insulin resistance, may benefit metabolic state.
- Trial name
- NCT00283816
- Testing
- Metformin, Oral Contraceptive Pill, Lifestyle Management Program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
PCOS
The Mechanism of Modified Utral-long Protocol in Improving Endometrial Receptivity in Patients With PCOS and IR
NF-κB pathway activation-induced endometrial insulin resistance was one of the causes of infertility patients with PCOS and insulin resistance whose endometrial receptivity is declined .The investigators' previous findings…
- Trial name
- NCT03100240
- Testing
- Modified Supper Long Protocol
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
PCOS (Polycystic Ovary Syndrome)
LH/FSH, Testosterone, Prolactin, and Ferritin in PCOS Patients in Jordan
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder impacting women of reproductive age. Characterized by chronic anovulation, hyperandrogenism, and the presence of multiple small ovarian cysts.
- Trial name
- PCOS patients (NCT07112768)
- Testing
- Serum levels of LH, FSH, testosterone, prolactin, and ferritin
- Where
- Jordan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
PCOS, Polycystic Ovary Syndrome
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS.
- Trial name
- CRM010 (NCT04597099)
- Testing
- Micronized progesterone, Flutamide, Estradiol patch
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hyperandrogenism, Insulin Resistance
Meal Timing on Glucose Metabolism and Hyperandrogenism in Lean Women With Polycystic Ovary Syndrome
In obese women with polycystic ovary syndrome (PCOS), weight loss improves insulin resistance and hyperandrogenism, resulting in improvement of clinical symptoms.
- Trial name
- M-PCOS (NCT01569425)
- Testing
- Dietary intervention
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Polycystic Ovary Syndrome, Hypovitaminosis D
The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS)
This is a prospective double-blind, randomized, parallel-group, placebo-controlled trial designed to examine the effect of supplementation with 50,000 IU vitamin D3 for 3 months on Polycystic Ovary Syndrome (PCOS) prognosis…
- Trial name
- NCT02328404
- Testing
- 50,000 IU vitamin D3
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hayat Pharmaceutical Co. PLC