Clinical trials: PCOS
Gestational Diabetes Mellitus, Preeclampsia
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is a heterogeneous condition, characterised by metabolic disturbances, insulin resistance and hyperandrogenism.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Preterm Birth, Polycystic Ovary Syndrome
- Trial name
- MYPP (NCT05524259)
- Testing
- Myo-inositol and routinely recommended folic acid, Routinely recommended folic acid
- Where
- Netherlands
- Volunteers
- 464 people
- Sponsor
- Erasmus Medical Center
Polycystic Ovary Syndrome (PCOS), Thrombophilia
Construction of a Multi-dimensional Risk Assessment System: a Clinical Study of Polycystic Ovary Syndrome Complicated With Thrombophilia
This observational case-control study aims to develop a multidimensional risk assessment model for thrombophilia-related abnormalities in females with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07571096
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangdong Women and Children Hospital
Polycystic Ovary Syndrome, Insulin Resistance
PCOS & Insulin Resistance Exercise Study
This study evaluates the feasibility and metabolic effects of implementing a structured exercise program in women with polycystic ovary syndrome and insulin resistance.
- Trial name
- NCT02303470
- Testing
- Vigorous Exercise, Moderate Exercise
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome
Light Fasting Diet and Magnesium in Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, which is associated with hormonal imbalances, dyslipidemia, chronic inflammation, and increased oxidative stress, and…
- Trial name
- NCT07322120
- Testing
- Light fasting, Magnesium supplementation
- Volunteers
- 46 people
- Sponsor
- Behnood Abbasi
Polycystic Ovary Syndrome
Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women of reproductive age and despite decades of research the etiology the disorder is not known.
- Trial name
- PULSE (NCT01482286)
- Testing
- Metformin, Dietary Restriction, Exercise Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Pennington Biomedical Research Center
Polycystic Ovary Syndrome
The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women of reproductive age and is a leading cause of infertility due to anovulation.
- Trial name
- NCT02866786
- Testing
- Metformin, ethinyl estradiol and cyproterone acetate
- Where
- India
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- S.C.B. Medical College and Hospital
Polycystic Ovary Syndrome, Chronic Periodontitis
Chronic Periodontitis and Polycystic Ovary Syndrome
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic…
- Trial name
- NCT02954120
- Testing
- no intervention provided
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Uric Acid Concentration, Serum, Quantitative Trait Locus 7, Polycystic Ovary Syndrome
Metabolic Differences Between Subtypes of Polycystic Ovary Syndrome
We aimed to investigate serum uric acid levels in patients with different phenotype of policystic ovary syndrome and to compare healthy controls.
- Trial name
- NCT06342180
- Testing
- Serum uric acid level
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Uşak University
Polycystic Ovary Syndrome
PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene
1. Metformin increases the pregnancy rate when added to the standard treatment of anovulatory polycystic ovary syndrome (PCOS). 2.
- Trial name
- PCOSMIC (NCT00795808)
- Testing
- Metformin, Metformin + Clomiphene, Clomiphene
- Where
- New Zealand
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
PCOS
Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatment Cycles for the First Frozen Embryo Transfer in Women With PCOS
This is a multicenter randomized controlled trial comparing the efficacy and safety of two endometrial preparation protocols for the first frozen embryo transfer cycle in PCOS with whole embryo freezing.
- Trial name
- NCT05227391
- Testing
- Oral Letrozole, Oral estradiol valerate
- Where
- China
- Volunteers
- 1,078 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Polycystic Ovary Syndrome
Expression of CVD and HA Between Obesity and Non-obesity Polycystic Ovary Syndrome (PCOS) Women in Taiwan
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in reproductive women. It is estimated that 5 to 10% of women of reproductive age have PCOS.
- Trial name
- NCT01113918
- Where
- Taiwan
- Volunteers
- 627 people
- Sponsor
- Taipei Medical University WanFang Hospital
Polycystic Ovary, Depression
The Effect of Polycystic Ovary Syndrome Phenotypes on Quality of Life and Sexual Function
This study was planned to examine whether different phenotypes of PCOS have an effect on quality of life, depression inventory and sexual function.
- Conditions
- Polycystic Ovary, Depression, Sexual Dysfunction
- Trial name
- PCOS (NCT06428786)
- Testing
- Female Sexual Function Index
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Polycystic Ovary Syndrome, Endothelial Dysfunction
Metformin+ Drospirenone/ethinylestradiol30µg and Flow-mediated Dilation in Polycystic Ovary Syndrome
The purpose of this study is to assess the effects of ethinylestradiol 30µg-drospirenone combined with metformin and weight loss by means of dietary intervention on the indices of endothelial dysfunction (i.e.
- Trial name
- NCT01459445
- Testing
- Metformin, Ethinylestradiol 30µg-Drospirenone
- Where
- Romania
- Volunteers
- 26 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Polycystic Ovary Syndrome
Serum Anti-mullerian Hormone and Polycystic Ovarian Syndrome
In 1935 the polycystic ovary syndrome was a clinical diagnosis made on the morphological appearance of the ovaries in association with amenorrhoea, hirsutism and frequently obesity.
- Trial name
- NCT03237312
- Testing
- Laparoscopic ovarian drilling, Antimullerian hormone
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome
Effects of Melatonin in PCOS Women
The aim of our study is to investigate the effects of a treatment with melatonin on clinical, endocrine and metabolic features in women affected by PCOS.
- Trial name
- NCT02663570
- Testing
- Melatonin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Polycystic Ovary Syndrome
Effect of NMN (Nicotinamide Mononucleotide) on Polycystic Ovary Syndrome
The purpose of the study is to understand the effect of Nicotinamide mononucleotide (NMN) on patients with polycystic ovary syndrome.
- Trial name
- NMN (NCT05305677)
- Testing
- NMN intervention
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Peking University Third Hospital
Sterility, Infertility
Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology
This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.
- Trial name
- NCT03177122
- Testing
- Myo-inositol
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Weight Loss
Infertile Polycystic Ovary Syndrome (PCOS) Women With Obesity and Lifestyle Changes
Infertile PCOS women with obesity were included into lifestyle change weight loss program prior to inclusion to IVF procedures. They attended group as well as individual workouts and they were advised on healthy eating.
- Trial name
- NCT04989244
- Testing
- Weight loss program
- Where
- Slovenia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana