Clinical trials: PALS
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study
The goal of this clinical trial is to learn how doing mechanical insufflation (MI) using a mechanical insufflator-exsufflator (MI-E) device affects breathing in early amyotrophic lateral sclerosis (ALS).
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular Diseases
- Trial name
- MI-PALS (NCT06119087)
- Testing
- Mechanical insufflation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Sepsis
LifeFlow Sepsis Study
This is a prospective, comparative, blinded, randomized study to prove the safety, efficacy and ease of use of the LifeFlow® device in pediatric patients presenting to an emergency department with concern for sepsis.
- Trial name
- NCT07191054
- Testing
- LifeFlow Rapid infuser, Push Pull
- Where
- United States
- Sponsor
- Phoenix Children's Hospital
Iron Deficiency
Evaluation of Iron Bioavailability From Iron Chlorophyllin
The overall objective of this study is to evaluate the iron absorption from iron chlorophyllin. Iron deficiency is a public health problem in both developing and industrialized countries.
- Trial name
- NCT04602247
- Testing
- SIC, SIC + AA combined, FeSO4
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Diffuse Glioma, Radionecrosis of Brain
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
Diffuse gliomas are common tumors involving the brain. They are usually treated by surgery followed by radiation and chemotherapy. Radiotherapy is used for the treatment of brain tumors which causes damage to the tumor cells.
- Conditions
- Diffuse Glioma, Radionecrosis of Brain, High Grade Glioma, Glioblastoma Multiforme
- Trial name
- CHROME (NCT06016452)
- Testing
- Chlorophyllin
- Where
- India
- Volunteers
- 118 people
- Sponsor
- Tata Memorial Centre
Amyotrophic Lateral Sclerosis (ALS)
Examining Interactions Between PALS and Caregivers
The goal of this clinical trial is to learn about the effect of communicative interaction on verbal communication in people with amyotrophic lateral sclerosis (ALS) and their caregivers.
- Trial name
- NCT06819124
- Testing
- Structured Communicative Interaction, Unstructured communicative interaction
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Penn State University