Clinical trials: Oxygen Deficiency
Hypoxia, Desaturation of Blood
SpO2 Accuracy Low Saturation Validation of the OxySoftN Sensor
To compare prototype pulse oximeter saturation measurements, during normal to low saturation, to saturation measurements made by a multi-wavelength CO-oximeter, taken from arterial blood samples from healthy human subjects.
- Trial name
- NCT04811963
- Testing
- Non-Invasive Controlled Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Perinatal Hypoxia
Serum Erythropoietin Level in Perinatal Asphyxia
This study is to evaluate brain and kidney injuries in full-term neonates with perinatal asphyxia by detecting specific biomarker in blood (Erythropoietin).
- Trial name
- NCT05018364
- Testing
- Serum erythropoietin level
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Retinal Oxygenation, Retinal Blood Flow
Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation
Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process…
- Trial name
- NCT01692821
- Testing
- 100% oxygen breathing, 15% oxygen in N2 breathing, 12% oxygen in N2 breathing
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Collect Blood Values With Induced Hypoxia, Induced Methemoglobinemia, and Induced Hypoxia and Methemoglobinemia
Accuracy of Detection of Methemoglobin With Pulse Oximetry
The non-invasive measurement of dysfunctional hemoglobins allows physicians to monitor levels in affected individuals without requiring blood samples or laboratory testing.
- Trial name
- NCT03869840
- Testing
- Sensor to spot check blood levels
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Nonin Medical, Inc
Hypoxia
Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia
The goal of this study was to evaluate the accuracy of pulse oximeters over the range of 70-100% per the International Organization for Standardization (ISO) 80601-2-61:2019.
- Trial name
- NCT06459206
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Movano Health
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Healthy
Effect of Intermittent Hypoxia in Healthy Individuals
The use of acute intermittent hypoxia (AIH) has been examined in animal and human studies to gain an understanding of its effect on spinal excitability and synaptic strength.
- Trial name
- NCT04691518
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Healthy
Catecholamines Can Attenuate Intermittent Hypoxia-Induced Expression of TNF in Human Monocytes
Specific aim To examine the effect of catecholamines on the modulation of intermittent hypoxia induced TNF- in human monocytes from both healthy subjects and OSA patients (2).
- Trial name
- NCT00498862
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypoxia
SpO2 Accuracy Comparison of Smart Sock V. 2 SpO2 to Arterial Blood CO-Oximetry
Pulse oximetry monitoring is considered a standard physiological measurement and is used by clinicians in everyday situations to estimate arterial oxygen saturation.
- Trial name
- NCT03630016
- Testing
- Pulse oximetry with Owlet BabySat v1.0 sensor
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Owlet Baby Care, Inc.
Healthy
Validation of Brain Oxygenation Monitor
A cerebral oximeter is a device that uses light to measure the amount of oxygen within the brain. It is similar to the device that measures the level of oxygen in the tip of the finger, known as a pulse oximeter.
- Trial name
- NCT00815490
- Testing
- Desaturation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypoxia
Pulse Oximeter Test
Assessment of Spry Health's Loop oximetry accuracy in profound hypoxia
- Trial name
- NCT03569163
- Testing
- Spry Loop oximeter
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Spry Health
High-intensity Strenght Training in Normoxia (H-N), Low-intensity Strenght Training in Normoxia (L-N)
Normobaric Hypoxia as a Strength Training Intensity Amplifier in Ice Hockey Players: Effects on Anaerobic Performance and Muscle Contraction Properties
The goal of this research study is to investigate the effects of resistance training performed under normobaric hypoxia (simulated altitude conditions) on anaerobic performance, lactate clearance, and muscle contractility in…
- Conditions
- High-intensity Strenght Training in Normoxia (H-N), Low-intensity Strenght Training in Normoxia (L-N), High-intensity Strenght Training in Normobaric Hypoxia (H-H), Low-intensity Strenght Training in Normobaric Hypoxia (L-H)
- Trial name
- NCT06930027
- Testing
- Resistance Training (High-Intensity), Resistance Training (Low-Intensity), Normobaric Hypoxia
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Hypoxia
Ketone Esters for Optimization of Operator Performance in Hypoxia
The primary purpose of the study was to investigate effects of an orally administered ketone ester drink on endurance exercise performance during acute extreme hypoxia.
- Trial name
- HVMN7 (NCT07065864)
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Hypoxia, Confinement
Intravascular Volumes in Hypoxia During Antarctic Confinement
This study evaluates the effect of hypoxia on blood volumes during Antarctic winter-over confinement. Half of the participants will be evaluated during sea-level winter-over confinement, while the other half will be examined…
- Trial name
- ANTARCV (NCT04106401)
- Testing
- carbon-monoxide rebreathing, venous blood sampling, physical activity monitoring
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ecole Nationale des Sports de Montagne
Altitude, Hypoxia
Tübingen High Altitude Ophthalmology Study
Tuebingen High Altitude Ophthalmology Study to investigate the effects of high altitude on retinal structure and function as well as anterior chamber in regard to acute mountain sickness.
- Trial name
- THAO (NCT01245114)
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Hypoxia
Preoxygenation With Nasal Cannula and Noninvasive Positive Pressure Ventilation
This is a prospective randomized cross over study of healthy volunteers comparing end-tidal oxygen concentration among subjects undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (NIV) mask…
- Trial name
- NCT03093662
- Testing
- Ventilation with nasal cannula, Ventilation without nasal cannula
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Respiratory Failure With Hypoxia
Clinical Comparison of Flow Regulated Nasal Oxygen Delivery System (FRNDS) Cannula and Plethysmography Belts
SUMMARY: This is a quantitative, non-inferiority study using healthy participants to compare tidal volumes at rest measured by both a standard RIP belt and a flow-regulated nasal oxygen delivery system FRNDS cannula.
- Trial name
- FRNDS (NCT06713213)
- Testing
- Flow-regulated nasal oxygen delivery system (FRNDS)
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Hypoxia, Brain, Hyperoxia
The Effect of Respiratory Challenge on the BOLD Signal
The purpose of this research study is to better understand how blood flow and metabolism are different between normal controls and patients with disease.
- Conditions
- Hypoxia, Brain, Hyperoxia, Hypercapnia, Hypocapnia
- Trial name
- NCT04258774
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Vasodilation, Hypoxia
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.
- Trial name
- NCT05256069
- Testing
- Propranolol Pill
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia