Clinical trials: Oxidative Stress
Sleep Apnea
The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Obstructive Sleep Apnea (OSA) is the most common sleep disorder affecting up to 9-24 percent of middle aged adults, and is becoming increasingly implicated in the pathogenesis of hypertension, and other cardiovascular disorders.
- Trial name
- NCT00701441
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rami Khayat
Fatigue
Efficacy of Vitamin C Injection on Fatigue in Workers After Work
Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause.
- Trial name
- NCT00633581
- Testing
- Ascorbic acid (Vitamin C), Normal saline
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- DongGuk University
Oxidative Stress
SIMOX - Induction of Oxidative Stress
The purpose of the study is to investigate if use of simvastatin is associated with the level of oxidative stress in humans. The association is examined by comparing changes in oxidative stress in a group treated with simvastatin…
- Trial name
- SIMOX (NCT02256254)
- Testing
- Simvastatin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bioavailability
Bioavailability and Bioactivity of Red Wine Melatonin in Humans
Melatonin (MLT) is a bioactive compound in red wine. The investigators will investigate the serum and salivary concentrations and antioxidant power of MLT after the intake of a glass of red wine.
- Trial name
- Wine-MLT (NCT02767102)
- Testing
- Red wine with melatonin, Red wine without melatonin
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Milan
Oxidative Stress, Inflammation
Milk and Soured Milk (filmjölk) Intervention on Oxidative Stress and Inflammation
This study evaluates a high intake of milk compared with a high intake of soured milk (Swedish filmjölk) on markers of oxidative stress and inflammation in a randomized crossover intervention study.
- Trial name
- NCT03821116
- Testing
- Milk, Soured milk (filmjölk)
- Where
- Sweden
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Cardiovascular Disease
Dose-dependent Effects of Second-hand Smoke on Vascular Function
The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.
- Trial name
- NCT01007760
- Testing
- Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Infertility, Female
Melatonin Study Between Diminished and Normal Responder in IVF
Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function.
- Trial name
- NCT03117725
- Testing
- Melatonin adminstration
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bundang CHA Hospital
PCOS, Endometriosis
Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
tTe investigators estimate pomegranate supplementation effect on oxidative stress in infertile women with PCOS, endometriosis and advanced maternal age during IVF treatment.
- Conditions
- PCOS, Endometriosis, Advised Maternal Age, Male Factor Infertility
- Trial name
- NCT03978013
- Testing
- Pomegranate juice, Apple juice
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Healthy, Athletes
Evaluation of the Ergogenic Properties of Hesperetin on Exercise-induced Fatigue
Twenty young, healthy, physically active men and women (12~30 years) did a pre-post trial randomized into placebo or HST trials (500 mg/d for two weeks).
- Trial name
- NCT07104734
- Testing
- Hesperetin (Hesperetin trial)
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Oxidative Stress
Effect of Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers
The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult…
- Trial name
- NCT00876811
- Testing
- individually quick frozen red raspberries
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Inflammation
The Effects Grapes on Health Indices
The investigators hope to learn about the effects of whole grapes, in the form of freeze-dried grape powder, on markers of health.
- Conditions
- Obesity, Inflammation, Cardiovascular Disease, Oxidative Stress
- Trial name
- NCT01674231
- Testing
- Grape in the form of freeze-dried whole grape powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Sedentary
Comparison of Gut Microbiota in Sedentary and Active Women
Gut microbiota comparison of active and sedentary women
- Trial name
- NCT02901912
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Amyotrophic Lateral Sclerosis
Mitochondrial Functions and Oxidative Stress in ALS Patients
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor.
- Trial name
- NCT00331812
- Testing
- Mitochondrial functions and oxidative stress
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Muscle Soreness, Muscle Damage
The Chronic Effects of Carnitine on Recovery
This study investigated the effects of CarnipureTM, a high-quality L-carnitine ingredient, on long term (5 weeks) recovery, muscle damage, and SOD status in a population of males and females while training two days per week.
- Conditions
- Muscle Soreness, Muscle Damage, Resistance Training, Oxidative Stress
- Trial name
- NCT04420377
- Testing
- Carnipure, Resistance Training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Healthy
Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans
Objectives: This proposal addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress.
- Trial name
- NCT00434005
- Testing
- N-acetylcysteine, ascorbate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pregnancy Complications, Maternal Obesity
Gasdermin-D and Pannexin-1 in Pregnancy
One -third of fertile women around the world are overweight or obese. This means increasing risk for both the mother and the child.
- Trial name
- NCT05475951
- Testing
- Biomarker measurement of pannexin-1 and gasdermin-D
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Oxidative Stress
Examining Endogenous Antioxidant Levels in Well Trained Cyclists
This study will investigate whether increased habitual intake of antioxidant supplements effects the concentration of endogenous antioxidants, the response of antioxidants to exercise, and differences in oxidative damage compared…
- Trial name
- NCT02281851
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Birmingham