Clinical trials: Ovulation Disorder
Polycystic Ovary Syndrome, Anovulation
LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound .
- Trial name
- NCT04325295
- Testing
- Laparoscopic ovarian drilling, Recombinant FSH (rFSH)
- Volunteers
- 200 people
- Sponsor
- Assiut University
Type 1 Diabetes, Polycystic Ovary Syndrome
Prevalence of Hyperandrogenism in Type 1 Diabetes
The investigators aim to estimate the prevalence of functional ovarian hyperandrogenism [idiopathic hyperandrogenism, idiopatic hirsutism, and polycystic ovary syndrome (PCOS)] in adult patients with type 1 diabetes (T1DM) in an…
- Conditions
- Type 1 Diabetes, Polycystic Ovary Syndrome, Hyperandrogenism, Hirsutism
- Trial name
- NCT04979377
- Testing
- Clinical hyperandrogenism assessment, Total testosterone (ng/dL), A1c (%)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Infertility
Study of Axillary Skin Temperature as a Marker of Ovulation
Infertility is the most common reason women (aged 20-45yrs)see their GP, affecting 1 in 7 couples. Measuring basal body temperature is a technique that has been used since the 1930's to attempt to predict ovulation.
- Trial name
- NCT01360684
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Joanne Outtrim
Ovulation Disorder
Human Chorionic Gonadotrophin & Trigger
In women being treated with medicines to help eggs to grow (called ovulation induction), The investigators wish to know whether adding medicines (called ovulation triggers) that help to release the egg (ovulation) would lead to…
- Trial name
- NCT02264847
- Testing
- Human chorionic gonadotrophin, clomiphene citrate alone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Female Infertility
Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome
Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome.
- Trial name
- ProgBBN (NCT01426152)
- Where
- Germany
- Volunteers
- 2,555 people
- Sponsor
- Bollmann Bruckner Noss
Polycystic Ovary Syndrome
Prevalence of Pregnancy in Polycystic Ovary Syndrome
Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, with a prevalence of approximately 5-10%.
- Trial name
- NCT03157921
- Testing
- transvaginal ultrasound, Hormonal levels
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Infertility
Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders
The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered…
- Trial name
- NCT07569315
- Testing
- Successive doses GnRH agonist, Single dose GnRH agonist
- Where
- Egypt
- Volunteers
- 190 people
- Sponsor
- Bedaya Hospital
Polycystic Ovarian Syndrome
Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian Syndrome
This study examines Raloxifene versus Clomiphene to induce ovulation in women with polycystic ovarian syndrome (PCOS).
- Trial name
- PCOS (NCT01607320)
- Testing
- Raloxifene, Clomiphene
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bruce Lessey
Infertility
Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures
Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural…
- Trial name
- NCT02048891
- Testing
- GnRH agonist trigger, hCG trigger
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Rambam Health Care Campus
Polycystic Ovary Syndrome
Metformin Administration in Infertile Anovulatory PCOS Patients
In a recent prospective study evaluating the efficacy of 1700 mg/day metformin as first-line approach for infertile anovulatory patients with PCOS, we identified predictors for metformin efficacy.
- Trial name
- NCT00501787
- Testing
- Metformin
- Where
- Italy
- Sponsor
- University Magna Graecia
Sub Fertility, Female, Fertility Disorders
Feasibility and Safety of Fasting in Fertility Treatment
This exploratory study investigates fasting as a potential supportive therapy in infertility treatment for women suffering from infertility
- Conditions
- Sub Fertility, Female, Fertility Disorders, Cycle Disorders Menstrual, Ovulation Disorder
- Trial name
- KiWuA (NCT04942457)
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Charite University, Berlin, Germany
Ovulation Induction
Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction
This is an open-label, prospective, randomized, controlled, multicentric, multinational, phase IV study to evaluate the use of Gonal-f in inducing ovulation in female subjects with chronic anovulation.
- Trial name
- NCT01081626
- Testing
- Recombinant FSH (follitropin alpha)
- Where
- 3 sites in Kuwait, Lebanon and 1 more
- Volunteers
- 310 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility (IVF Patients)
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36…
- Trial name
- NCT07569302
- Testing
- Modified dual trigger, HCG
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Bedaya Hospital
Infertility
Predictive Factors of Ovarian Response in Ovulation Induction With Intrauterine Insemination of a Gonal-f Low-dose Regimen
This is a single center, prospective, observational study on the use of Gonal-f in controlled ovarian hyperstimulation (COH) in subjects undergoing ovulation induction/ intrauterine insemination (OI/IUI) therapy across Taiwan.
- Trial name
- NCT01100346
- Testing
- Gonal-f (Follitropin alpha)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Anovulatory Infertility Related to Polycystic Ovary Syndrome
Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS
Anovulatory infertility is a common feature of the polycystic ovary syndrome (PCOS). Even if several first-step treatments have been proposed for anovulatory infertile PCOS patients, very few data are available in literature…
- Trial name
- NCT00461643
- Testing
- Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
- Where
- 3 sites in Italy
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Anovulation
Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction
The purpose of this study is to investigate and compare the safety and efficacy of various doses of the aromatase inhibitor (anastrozole) versus clomiphene citrate in stimulating follicular growth and ovulation in infertile women…
- Trial name
- NCT00213148
- Testing
- Anastrozole 1 mg, Anastrozole 5 mg, Anastrozole 10 mg
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- EMD Serono
Infertility, Miscarriage
International NaProTechnology Evaluation and Surveillance of Treatment for Infertility and Miscarriage (iNEST)
NaProTechnology (NPT) is a treatment option for infertility or miscarriage that identifies issues in a couple's fertility and fixes them to the extent possible by medical intervention.
- Trial name
- iNEST (NCT01363596)
- Testing
- Creighton Model System in conjunction with Natural Procreative Technology (NPT)
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 834 people
- Sponsor
- University of Utah
Infertility
Comparison of 3 Different Protocols for Preventing Premature Ovulation in Ovarian Stimulation Cycles
The aim of study is to evaluate the results of three different protocols for prevention of premature ovulation in ovarian stimulation cycles. All patients that undergo IVF cycles are randomly divided into three groups.
- Trial name
- NCT05767086
- Testing
- Gonadotropin releasing hormone antagonist (Cetrotide), Medroxyprogesterone Acetate (Tarlusal), Dydrogesterone
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Functional Hypothalamic Amenorrhea, FHA
A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
This study is researching an experimental drug called mibavademab (also called "study drug"). The study is focused on participants with a condition called Functional Hypothalamic Amenorrhea (FHA).
- Trial name
- KYRIAD (NCT07235917)
- Testing
- Mibavademab
- Where
- 11 sites in United States
- Volunteers
- 34 people
- Sponsor
- Regeneron Pharmaceuticals