Clinical trials: Ovulation, open to volunteers
Contraception
Investigating Ovulation Inhibition for Use as a Contraceptive
A single-centre, open-label, randomised, phase II study on the maintenance of ovulation inhibition after intentional application errors during 84 days of treatment with MR 130A 01 contraceptive transdermal patch
- Trial name
- NCT07365904
- Testing
- MR-130A-01 contraceptive transdermal patch, containing norelgestromin (NGMN)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Poly Cystic Ovary Syndrome
Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol in Non-Diabetic PCOS Patients
This study evaluates the efficacy of alpha-lipoic acid combined with myo-inositol, with or without metformin, in improving menstrual regularity and ovulation in non-diabetic women with polycystic ovary syndrome (PCOS).
- Trial name
- ALA-MYO-PCOS (NCT07630779)
- Testing
- Myo-inositol, Folic Acid, Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Beni-Suef University
Stimulation in the Ovary, IVF Outcome
Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
There are several approaches to the timing of antagonist administration in IVF/ICSI cycles. The primary goal is indeed to prevent premature ovulation, which could jeopardize the success of the cycle There is an emerging concept…
- Trial name
- NCT06879002
- Testing
- Ovarian stimulation with menstruation or after ovulation
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility (IVF Patients)
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36…
- Trial name
- NCT07569302
- Testing
- Modified dual trigger, HCG
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Bedaya Hospital
Menstrual Cycle, Menstrual Distress (Dysmenorrhea)
Menstrual Cycle Symptoms and Female Health
The complexity inherent to the hormonal fluctuations associated with the female menstrual cycle (MC) has contributed, from a methodological perspective in research, to the neglect of women's physiological characteristics and to…
- Conditions
- Menstrual Cycle, Menstrual Distress (Dysmenorrhea), Premenstrual Syndrome, Abnormal Uterine Bleeding (AUB)
- Trial name
- CICLOS (NCT07699224)
- Testing
- Prevalence
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Universidad Rey Juan Carlos
Infertility, Female, Anovulatory Infertility
Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.
- Conditions
- Infertility, Female, Anovulatory Infertility, Menopause, Amenorrhea
- Trial name
- PRP (NCT03916978)
- Testing
- Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
PCOS (Polycystic Ovary Syndrome), Infertility
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
This randomized clinical trial aims to compare the efficacy and safety of extended letrozole therapy (5 mg/day for 10 days) versus standard letrozole therapy (5 mg/day for 5 days) for ovulation induction in women with polycystic…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Infertility, Anovulation
- Trial name
- PROLEx-PCOS (NCT07159880)
- Testing
- Traditional Letrozole Therapy, Extended Letrozole Therapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GABRIEL MONTEIRO PINHEIRO
Polycystic Ovarian Syndrome (PCOS)
Comparative Study Between HOMA1-IR and HOMA2-IR in Prediction of Ovulation Outcome in Women With PCOS
122 women diagnosed with PCOS seeking fertility in the fertility clinic at kasr Alainy hospital will be subjected to Homeostatic model assessment for insulin resistance 1 was calculated for all participants through the equation…
- Trial name
- NCT06793904
- Testing
- Aromatase inhibitor Letrozole
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Abnormal Uterine Bleeding (AUB), Ovulation Dysfunction
Clinical Efficacy And Safety of Dydrogesterone In The Treatment Of Abnormal Uterine Bleeding During Puberty
This multicenter prospective cohort study evaluates the clinical efficacy and safety of dydrogesterone versus drospirenone and ethinylestradiol in adolescents aged 10-19 years with abnormal uterine bleeding-ovulatory dysfunction…
- Trial name
- NCT07703488
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Guangdong Women and Children Hospital
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Letrozole, Clomiphene Citrate
LE + CC vs. LE for Ovulation Induction
This randomized controlled trial (RCT) aims to evaluate whether, in infertile women with WHO II/IV ovulatory disorders, a combination of letrozole (LE) and clomiphene citrate (CC) compared to LE alone, result in higher live birth…
- Conditions
- Letrozole, Clomiphene Citrate, Ovulation Disorder, Ovulation Induction
- Trial name
- COLA (NCT06934785)
- Testing
- IUI or intercourse
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Oncological Disease, Fertility Preservation
Ovulation Induction With GnRH Analogue or Dual Trigger?
Most medically assisted procreation (ART) techniques, including oocyte cryopreservation for fertility preservation, involve controlled ovarian stimulation.
- Trial name
- NCT07546136
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Polycystic Ovary Syndrome, Anovulation
Effect of Vitamin D on Ovulation Rate in Women With Polycystic Ovary Syndrome
This is a randomized double-blind controlled trial on the effect of vitamin D supplementation to assess the ovulation rate of women with polycystic ovary syndrome (PCOS) and other reproductive, endocrine and metabolic outcomes…
- Trial name
- NCT04650880
- Testing
- Vitamin D
- Where
- 3 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The University of Hong Kong
Low Dose, Progesterone
Role of Low Dose Injectable Progesterone in Triggering Ovulation
The aim of this study is to evaluate the role of low dose injectable progesterone in triggering ovulation.
- Conditions
- Low Dose, Progesterone, Triggering Ovulation
- Trial name
- NCT06928844
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- The General Authority for Teaching Hospitals and Institutes
Assisted Reproductive Techniques
Trial Comparing Subcutaneous Natural Progesterone (Prolutex) vs. Cetrorelix Acetate for Luteinizing Hormone Surge Suppression in Freeze-All IVF Cycles.
The prevention of premature luteinizing hormone (LH) surge during controlled ovarian stimulation (COS) is critical for optimizing outcomes in assisted reproductive technology (ART).
- Trial name
- IVF ART (NCT07350317)
- Testing
- Control Group (A):, Test Group (B):
- Volunteers
- 230 people
- Sponsor
- Trust Fertility Clinic
Embryo Transfer
Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle
The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols.
- Trial name
- 17FET (NCT07088952)
- Testing
- Trigger at smaller folicular size
- Where
- Spain
- Volunteers
- 572 people
- Sponsor
- Vida Recoletas Sevilla
Pregnancy Related, Fertility Issues
Luteal Phase Support in IUI MOH Treatment Luteal Phase Support in IUI MOH Treatment
The LUMO study is a multicenter, randomized controlled trial that evaluates the effectivity of luteal phase support in MOH/IUI treatment.
- Conditions
- Pregnancy Related, Fertility Issues, Luteal Phase Defect, Infertility Unexplained
- Trial name
- LUMO (NCT05080569)
- Testing
- Progesterone Vaginal Product
- Where
- Netherlands
- Volunteers
- 1,008 people
- Sponsor
- UMC Utrecht
Ovulation, Ovarian Function
Exogenous Progesterone as Ovulation Trigger
The goal of this clinical trial is to learn whether the sudden administration of vaginal micronized progesterone during the late follicular phase can trigger an LH surge and reactivation of oocyte meiosis in healthy oocyte donors…
- Conditions
- Ovulation, Ovarian Function, Assisted Reproductive Treatments, Oocyte Maturation
- Trial name
- PRO-TRIGGER (NCT07466199)
- Testing
- Vaginal micronized progesterone
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa