Clinical trials: Ovulation
Infertility, Female, Infertility
Use of Clomiphene Citrate as an Inhibitor of Ovulation in an Oocyte Cryopreservation Cycle
In vitro fertilization (IVF) has helped countless couples conceive where they otherwise were unable, but does come at a significant cost.
- Trial name
- CCOI (NCT05866068)
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Neil Chappell
Infertility, Pertubation
Effect of Pertubation on Pregnancy Rates Before Intrauterine Insemination Treatment
To demonstrate a possible beneficial impact of pertubation we designed a randomized prospective study, in which uterine washing was administered prior to insemination in patients diagnosed with unexplained infertility.
- Conditions
- Infertility, Pertubation, Insemination
- Trial name
- NCT01999959
- Testing
- Pertubation
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Gazi University
Hypogonadotropic Hypogonadism
Clinical Outcomes in WHO Type I Anovulatory Women Using r-hFSH+r-hLH in a 2:1 Ratio or hMG-HP
The aim of the study is to compare the efficacy and safety of r-hFSH+r-hLH in a 2:1 ratio with human Menopausal Gonadotropin Highly Purified (hMG-HP), in WHO type I anovulation, HH women.
- Trial name
- NCT01623570
- Testing
- Pergoveris: 150IU r-hFSH + 75IU r-hLH, Menopur: HMG-HP (150 IU)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Centro Riproduzione e Andrologia
Obesity, Maternal
The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Women
This study aims to explore whether the application of low-dose HCG in luteal support can improve the pregnancy outcomes of natural cycle frozen embryo transfer in obese patients
- Trial name
- NCT07633002
- Testing
- Human Chorionic Gonadotropin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Infertility, Monofollicular Development
Low-dose Gonal-f® in Ovulation Induction
This is a prospective, multicenter, open-label, comparative and parallel-group study of ovulation induction evaluating tailoring of Recombinant follicle stimulating hormone (FSH) treatment using the Gonal-f® prefilled pen in…
- Trial name
- LoGo (NCT01871532)
- Testing
- Gonal-f®
- Where
- 10 sites in Ireland, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome
Combination Letrozole and Clomiphene Citrate Versus Letrozole Alone
Clomiphene citrate is a non-steroidal triphenylethylene derivative distantly related to diethylstilbestrol. It acts as a selective estrogen receptor modulator (SERM), similar to tamoxifen and raloxifene.
- Trial name
- NCT06507332
- Testing
- Letrozole 2.5mg
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Egymedicalpedia
Infertility, Female, Clomiphene Citrate
Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer
Clomiphene citrate has been widely used for treatment of infertility for decades. Although its anti-estrogenic effects leads to low pregnancy rate, clomiphene citrate is still a first-line treatment for ovulation induction…
- Trial name
- NCT03309436
- Testing
- Clomiphene Citrate protocol, Procedure
- Where
- China
- Volunteers
- 360 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
PCOS, Sleep Apnea
The SNORES Randomized Clinical Trial
Randomized clinical trial among women with polycystic ovary syndrome (PCOS) who present for fertility treatment to evaluate the impact of screening for obstructive sleep apnea.
- Trial name
- SNORES (NCT02442999)
- Testing
- Screening for obstructive sleep apnea, CPAP - continuous positive airway pressure
- Where
- 6 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of South Florida
IVF, Infertility, Female
Inhibin B/AFC Ratio for Ovarian Response
Ovarian response to gonadotropin stimulation plays a major role in the success of in vitro fertilization (IVF). Anti-müllerian hormone (AMH), inhibin B, and antral follicle count (AFC) are ovarian reserve markers and also…
- Conditions
- IVF, Infertility, Female, Ovulation Disorder
- Trial name
- NCT06292806
- Testing
- FSH-R
- Volunteers
- 144 people
- Sponsor
- Insemine Humen Reproduction Centre
Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days)
The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle
The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.
- Conditions
- Ovulation (Follicular Rupture Yes/no), Menstrual Cycles (Total Length, Bleeding Days), Gonadotropin and Ovarian Hormone Levels (FSH, LH, E2, P)
- Trial name
- NCT00614406
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Infertility
Individualization of Ovarian Stimulation Using AMH Maximizes the Benefits and Minimizes Complications and Risks
The purpose oh the study is to determine the usefulness of anti-Mullerian hormone (AMH) to identify women at risk of excessive and poor response in controlled ovarian stimulation (COS) for in vitro fertilization (IVF), and the…
- Trial name
- NCT01887652
- Testing
- conventional ovarian stimulation, individualized ovarian stimulation
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Infertility
Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest
This study aims at investigating the fertility outcome of endometriosis suppression with dienogest 2mg / day for 3 month followed by induction of ovulation for 3 month in endometriosis patients stage I and II.
- Trial name
- NCT02575248
- Testing
- Dienogest 2mg, Clomiphene citrate 5 mg
- Where
- Egypt
- Volunteers
- 310 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome
Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors
Hypothesis: Metformin treatment normalises hormone values and metabolic parameters in women with PCOS. Ovulation is restored and bleeding periods become regular.
- Trial name
- NCT00317928
- Testing
- Metformin
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital Skejby
Focus: Estrogen-free Oral Contraception
Efficacy Study of Two Continuous Regimens of Oral Daily 5 mg or 10 mg of Ulipristal Acetate (UPA), Versus a Dose of 5.0mg UPA for 24/4 Days
To compare the pharmacodynamic effects of 2 continuous dose regimens of ulipristal acetate 5.0 and 10.0 mg-only oral contraception, versus a 24/4 day regimen of UPA 5.0 mg.
- Trial name
- CCN013 (NCT01953679)
- Testing
- Ulipristal Acetate
- Where
- 10 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Premier Research
Abnormal Uterine Bleeding (AUB), Ovulation Dysfunction
Clinical Efficacy And Safety of Dydrogesterone In The Treatment Of Abnormal Uterine Bleeding During Puberty
This multicenter prospective cohort study evaluates the clinical efficacy and safety of dydrogesterone versus drospirenone and ethinylestradiol in adolescents aged 10-19 years with abnormal uterine bleeding-ovulatory dysfunction…
- Trial name
- NCT07703488
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Guangdong Women and Children Hospital
Unexplained Infertility
The Predictive Value of the Sperm Chromatin Dispersion Test, Halosperm®, Before and After Sperm Preparation for Clinical Pregnancy in Cases of Unexplained Infertility Treated With Intra-uterine Insemination (First Cycle) and Ovulation Induction With Clomiphene Citrate.
Recent research has revealed that subtle abnormalities can be found in sperm samples that seem to be normal with conventional analysis techniques.
- Trial name
- DNAFRAG (NCT02235103)
- Testing
- Sperm Chromatin Dispersion Test
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Ghent
Infertility
Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study
The purpose of the study is (A) to determine if the following novel approach improves the live birth rate with In-Vitro Fertilization (IVF) for women with a poor prognosis due to diminished ovarian reserve: ovarian stimulation…
- Trial name
- NCT01921166
- Testing
- clomiphene plus gonadotropins, Leuprolide flare
- Volunteers
- 23 people
- Sponsor
- Wake Forest University Health Sciences
Contraception
US Ovulation Inhibition Study in Obese Women
Birth Control Patch Study
- Trial name
- NCT00873483
- Testing
- Ethinylestradiol/Gestodene (BAY86-5016)
- Where
- 6 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Bayer
Poly Cystic Ovary Syndrome
E.N.D.E.A.V.O.R.: An Exemestane Needed Dose Efficacy and Verification as an Ovulation Induction Regimen Study
The goal of this clinical trial is to learn if study drug exemestane will increase chances of ovulation for patients with polyendocrine metabolic ovarian syndrome (PMOS, formerly called polycystic ovary syndrome (PCOS)).
- Trial name
- ENDEAVOR (NCT07706374)
- Testing
- Exemestane 25 MG, Exemestane 50 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill