Clinical trials: Ovulation
Polycystic Ovary Syndrome, Infertility
Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia contributes to chronic anovulation commonly encountered in women with PCOS. The first choice therapy is clomiphene citrate (CC).
- Trial name
- NCT01909141
- Testing
- induction of ovulation using letrozole-pioglitazone-metformin, induction of ovulation using clomiphene citrate-pioglitazone-metformin, transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Low Ovarian Reserve, Poor Ovarian Response
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)
This study aims to compare different ovulation triggering strategies in women with low ovarian reserve undergoing fresh in vitro fertilization (IVF) cycles.
- Trial name
- TRIGGERBEST (NCT07816562)
- Testing
- Human chorionic gonadotropin (hCG), Follitropin delta, Triptorelin
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
PCOS (Polycystic Ovary Syndrome), Infertility
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
This randomized clinical trial aims to compare the efficacy and safety of extended letrozole therapy (5 mg/day for 10 days) versus standard letrozole therapy (5 mg/day for 5 days) for ovulation induction in women with polycystic…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Infertility, Anovulation
- Trial name
- PROLEx-PCOS (NCT07159880)
- Testing
- Traditional Letrozole Therapy, Extended Letrozole Therapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GABRIEL MONTEIRO PINHEIRO
Polycystic Ovary Syndrome, Puberty Disorders
Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Puberty Disorders, Ovulation Disorder
- Trial name
- CBS009 (NCT04075149)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Embryo Transfer
Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle
The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols.
- Trial name
- 17FET (NCT07088952)
- Testing
- Trigger at smaller folicular size
- Where
- Spain
- Volunteers
- 572 people
- Sponsor
- Vida Recoletas Sevilla
Infertile Female Subjects Undergoing Controlled Ovarian Hyperstimulation to Suppress Premature LH Surge and Prevent Early Ovulation
To Compare the Efficacy and Safety of Oral SHR 7280 Tablets With Ganirelix Acetate Injection in Infertile Female Subjects
This study is a multi-center, randomized, double-blind, positive drug-controlled, non-inferiority Phase III clinical trial. The study will enroll approximately 316 infertile female subjects undergoing controlled ovarian…
- Trial name
- NCT05994378
- Testing
- SHR7280；Ganirelix Acetate Injection simulant, SHR7280 simulant； Ganirelix Acetate Injection
- Where
- China
- Volunteers
- 317 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Unexplained Infertility
New Protocol in Unexplained Infertility
The new protocol ANTIUI provides good results regarding ovulation and pregnancy rates in patients with unexplained infertility
- Trial name
- NCT04754243
- Testing
- Gonadotropin, Standard protocol in IUI
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Tanta University
Infertility
Cost Effectiveness Analysis for Induction of Ovulation in the Polycystic Ovary Syndrome by Letrozole Versus Clomiphene Citrate
To evaluate cost effectiveness of Letrozole versus clomiphene citrate (CC) in induction of ovulation in patients with polycystic ovary syndrome.
- Trial name
- NCT04361175
- Testing
- Letrozole, Clomiphine Citrate
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Assiut University
Premature Ovarian Failure
Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure
This study will determine whether giving estrogen replacement therapy through an estradiol patch can improve ovulation rates in women with spontaneous premature ovarian failure.
- Trial name
- NCT00370019
- Testing
- Estradiol/Medroxyprogesterone acetate
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility
Use of High Cost Monitoring During Letrozole Ovulation Induction
The purpose of this study is to investigate monitoring methods during ovulation induction cycles with letrozole and their effect on pregnancy rates.
- Trial name
- NCT01279200
- Testing
- Midcycle ultrasound + hCG injection, Urinary LH kits
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Polycystic Ovary Syndrome, Hyperandrogenism
Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility which affects 12-21% of the population.Several studies performed evaluate the possible benefit of metformin alone or in combination with…
- Trial name
- NCT02523898
- Testing
- metformine, clomiphene citrate
- Volunteers
- 388 people
- Sponsor
- Semnan University of Medical Sciences
Polycystic Ovary Syndrome, Infertility, Female
Comparison of Ovulation Induction Cycle Outcomes Between Early and Late Dose Increments for Low Dose Gonadotropin Step-up Protocol Among Infertile Women Diagnosed With Polycystic Ovary Syndrome: Prospective Randomised Trial
Low dose gonadotropin step-up ovulation induction treatment is the universally accepted and utilized teratment protocol for infertile women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT04528849
- Testing
- Gonadotropin dose increment timing
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Infertility
A Phase 3b Study to Evaluate Subject Satisfaction With Follitropin Alfa Injection in Oligoanovulatory Infertile Women Undergoing Ovulation Induction
This is a prospective, open-label, multicenter, trial evaluating subject satisfaction and efficacy with follitropin alfa injection applied by Pen device compared with the subject's previous experience with injectable…
- Trial name
- NCT00230815
- Testing
- Follitropin alfa injected by Pen device, Recombinant Human Choriogonadotropin (r-hCG)
- Volunteers
- 62 people
- Sponsor
- EMD Serono
Unexplained Infertility, Ovulation Disorder
Incremental Clomiphene Citrate Doses in Successive Cycles and FSH, LH and Steroid Hormone Levels
This study was planned to assess the initial and endogenous FSH, LH and steroid responses to incremental CC doses in successive ovulation induction cycles to treat anovulation in patients with unexplained infertility.
- Trial name
- NCT04210765
- Testing
- Clomiphene Citrate
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bagcilar Training and Research Hospital
Polycystic Ovary Syndrome
Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome
The Polycystic Ovarian Syndrome (PCOS) is a common disorder related to ovulation problems. Clomiphene citrate (CC) is the drug of first choice for this condition.
- Trial name
- NCT00427700
- Testing
- clomiphene citrate, raloxifene
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Infertility
Gametes Transfer vs. Embryo Transfer for Women Undergoing Assisted Reproductive Techniques: a Randomized Controlled Trial
Background: The cost for the treatment of infertility are limiting for the health care access, particularly if we consider that the success rate per cycle is approximately 35%.
- Trial name
- NCT01839136
- Testing
- Intrauterine transfer of gametes, Intrauterine transfer of embryos
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Infertility
Endometrial Injury for Assisted Reproduction
The objective of this study is to evaluate the effect of endometrial injury performed prior ovulation induction for assisted reproductive techniques main outcomes.
- Trial name
- NCT01132144
- Testing
- Endometrial injury, Control group
- Where
- Brazil
- Volunteers
- 158 people
- Sponsor
- University of Sao Paulo
Ovulation Induction
AS900672-Enriched in Ovulation Induction
This is a Phase 2, interventional, multi-center, randomized, assessor-blind, active-comparator, dose-finding study to evaluate a new investigational long-acting follicle stimulating hormone (FSH) in oligo-anovulatory women…
- Trial name
- NCT00553514
- Testing
- AS900672-Enriched 10 microgram (mcg), AS900672-Enriched 20 mcg, AS900672-Enriched 30 mcg
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pregnancy, Fertility
Home Ovulation Test One Cycle at Home Study
This study will assess the usability of a Home Ovulation Test when used at home by lay-users seeking to conceive.
- Trial name
- NCT04667858
- Testing
- Home Ovulation Test
- Where
- United Kingdom
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- SPD Development Company Limited
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern