Clinical trials: Overweight or Obese Adults
Overweight and Obesity
Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese
A phase 2 study to evaluate the effects of apitegromab as an adjunctive therapy to GLP-1 receptor agonist therapy in subjects with overweight or obesity
- Trial name
- EMBRAZE (NCT06445075)
- Testing
- Apitegromab, Tirzepatide
- Where
- 7 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Scholar Rock, Inc.
Obesity and Overweight
A Study of MET233 in Individuals With Obesity or Overweight
The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of once-weekly subcutaneous injections of MET233 in otherwise healthy adults with overweight or obesity.
- Trial name
- NCT07022977
- Testing
- MET233
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity & Overweight
WeDosify Real World Evidence (RWE) Study: Personalized Semaglutide Dosing in U.S. Adults
This research study is studying WeDosify, an interactive web-based Clinical Decision Support tool that assists healthcare professionals in managing adults with excess weight or obesity using a Glucagon-like peptide-1 (GLP-1) drug…
- Trial name
- NCT07216651
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Closed Loop Medicine
Overweight, Obesity
Study to Learn About How the Study Medicines Called PF-07976016 and PF-06882961 Are Taken Up by the Body, and if Either of Them Change How the Body Processes the Other Medicine in Otherwise Healthy Adults With Overweight or Obesity
The purpose of this study is to see how two study medicines, PF-07976016 and danuglipron, taken together affect the level of each other in the blood of participants who have overweight or obesity.
- Trial name
- NCT06910839
- Testing
- PF-07976016, PF-06882961
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Pfizer
Overweight and/or Obesity
Optimization of Dietary Adherence in a Mobile Weight Loss Intervention
The goal of this study is to test multiple individual treatment components added to a 6-month standard mobile behavioral weight loss program that are intended to help participants follow dietary recommendations and meet their…
- Trial name
- NCT07582536
- Testing
- Core, Switch to Simplified Diet Monitoring, Goal Autonomy/Planning
- Where
- United States
- Volunteers
- 580 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Overweight or Obese Adults
The 6-minute Pegboard and Ring Test in Overweight and Obese Individuals
The aim of our study is to investigate the validity and reliability of the 6-minute pegboard and ring test in overweight and obese individuals.
- Trial name
- NCT06742112
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Obesity, Morbid Obesity
Comparing Dumping Symptoms and Quality of Life 6 Months After Sleeve Gastrectomy With or Without Transit Bipartition in Adults With Obesity
This clinical study aims to compare two types of bariatric (weight loss) surgery used to treat obesity: sleeve gastrectomy alone and sleeve gastrectomy with transit bipartition.
- Conditions
- Obesity, Morbid Obesity, Dumping Syndrome, Postgastrectomy Syndrome
- Trial name
- STuD-QoL (NCT07263269)
- Testing
- Sleeve Gastrectomy, Sleeve Gastrectomy with Transit Bipartition
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mina Kamal Gergis Erian
Obesity, Obesity; Endocrine
Probiotic Blend in Reducing Anthropometric Measurements in Obese Adults
It is already known that dysbiosis, that is, qualitative and quantitative changes in the composition of the intestinal microbiota, can be associated with the development of a series of intestinal and extra-intestinal disorders.
- Conditions
- Obesity, Obesity; Endocrine, Overweight and Obesity, Overweight, Obesity and Other Hyperalimentation
- Trial name
- NCT05676229
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Overweight, Obesity
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Lifestyle Intervention for Visceral Fat Reduction in Adults With Overweight or Obesity
This is a single-center, randomized, open-label controlled trial with blinded outcome assessment and data analysis. Fifty adults with overweight or obesity (body mass index [BMI] >= 24 kg/m2) and a sedentary lifestyle will be…
- Trial name
- taVNS (NCT07907029)
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), Standardized lifestyle program (calorie-restricted diet plus aerobic exercise)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Hidradenitis Suppurativa
Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or Obesity
This study will test an experimental Regeneron drug called olatorepatide ("study drug") to see if it can help treat Hidradenitis Suppurativa (HS).
- Trial name
- NCT07830329
- Testing
- Olatorepatide
- Volunteers
- 300 people
- Sponsor
- Regeneron Pharmaceuticals
Type 2 Diabetes, Obesity
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk.
- Conditions
- Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight
- Trial name
- ACHIEVE-4 (NCT05803421)
- Testing
- Orforglipron, Insulin Glargine
- Where
- 358 sites in United States, Argentina and 14 more
- Volunteers
- 2,749 people
- Sponsor
- Eli Lilly and Company
Overweight, Obesity
Evaluation of the Planetary Health Diet Included in a Lifestyle Program in Overweight or Obese Mexican Adults.
The EAT-Lancet Commission proposed the planetary health diet as a strategy to achieve health and sustainability goals. Currently, its effect in the treatment of obesity has not been evaluated.
- Trial name
- NCT05309044
- Testing
- Planetary Health Diet Group, Low-fat diet group, Waiting list group
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Sonora
Obesity, Adiposity
The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction
This is a double-blinded randomized controlled trial, to evaluate the effectiveness of daily supplementation of 3.2 g CLA on body fat reduction and lipid profile in overweight or obese Chinese adults, during a lifestyle…
- Trial name
- NCT03915808
- Testing
- Conjugated linoleic acid group, Sunflower oil group
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Jiaomei Yang
Brain Insulin Sensitivity, Brain Vascular Function
High-Dairy Food Patterns and Gut-Brain Axis
Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT07355309
- Testing
- High-dairy food pattern, Low-dairy food pattern
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight, Obesity
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with…
- Trial name
- NCT07589608
- Testing
- Macupatide, Eloralintide
- Where
- 40 sites in United States
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company