Clinical trials: Overweight
Obesity, Oxidative Stress
Investigations of Botanicals on Food Intake, Satiety, Weight Loss, and Oxidative Stress
Despite widespread efforts to improve the treatment of obesity, only limited progress has been made. Calorie restriction (CR) has consistently been shown to produce weight loss, as well as delay the onset of age-related diseases…
- Trial name
- NCT01238887
- Testing
- Garcinia cambogia-derived hydroxycitric acid (2800 mg/day), Garcinia Cambogia derived Hydroxycitric Acid
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometrial Cancer, Obesity
Tirzepatide in Obesity-Driven Endometrial Cancer
LCCC2415 examines the antiproliferative effect of tirzepatide on the endometrium of endometrial cancer (EC). This is a pre-operative window clinical study.
- Trial name
- NCT07065552
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Intubation;Difficult, Obesity, Morbid
Face-to-face Intubation in Morbidly Obese
Introduction : In a typical endotracheal intubation, the patient is in the supine position, with the anesthetist standing behind his head and with adequate access to the head and neck of the patient.
- Trial name
- NCT04959149
- Testing
- AirTraq videolaryngoscope
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Medical University of Lodz
Acute Pancreatitis, Obesity
The Course of Acute Pancreatitis in Patients With Different BMI Groups
In obese (OB) patients, the presence of an increased inflammatory state in the body due to the increase in abdominal adipose tissue and increase in the frequency of gallstones and lipid levels are expected to increase the…
- Conditions
- Acute Pancreatitis, Obesity, Body Weight
- Trial name
- NCT04901949
- Where
- Turkey (Türkiye)
- Volunteers
- 1,334 people
- Sponsor
- Bezmialem Vakif University
Obesity
A Pilot Study of the Efficacy and Program Cost-effectiveness of Prevention Plus for Childhood Obesity
In 2007 the Expert Committee published recommendations on the prevention and treatment of childhood obesity. These recommendations outlined four interventions intended for advancement based on the child's age, body mass index…
- Trial name
- NCT01358448
- Testing
- growth monitoring, Growth Monitoring plus Family-based Behavioral Counseling
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- The University of Tennessee, Knoxville
Overweight and Obesity
Inhibitory Control and Pediatric Weight Management
The purpose of this pilot study is to explore the benefits of supplementing the Kurbo online program with a cognitive training game (PolyRules!) among youth ages 7-13 with overweight or obesity.
- Trial name
- NCT04747548
- Testing
- Kurbo Only, Kurbo + PolyRules!
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea
Simplus and Eson Non-Invasive Ventilation (NIV) Evaluation - Germany
This investigation is designed to evaluate the performance, comfort and ease of use of the Simplus and Eson masks amongst NIV patients who are currently on Bi-level therapy
- Conditions
- Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
- Trial name
- NCT02726048
- Testing
- Simplus/Eson
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Fisher and Paykel Healthcare
Healthy Volunteers
A Study of Multiple-ascending Doses of GSBR-1290 in Healthy Overweight/Obese Participants
The purpose of this study is to compare the safety, tolerability, pharmacokinetic (PK), and comparative bioavailability of repeated administration of GSBR-1290 in healthy overweight/obese participants.
- Trial name
- NCT06139055
- Testing
- GSBR-1290 (Capsule/Tablet), GSBR-1290
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Dietary Assessment, Dietary and Lifestyle Behaviour Change
BRE-13: Mediterranean Diet
Explore the effect of MedDiet vs. Usual Diet on circulating and breast tumor fatty acid profiles. The investigators aim to examine impact on tumor biology in newly diagnosed participants.
- Conditions
- Dietary Assessment, Dietary and Lifestyle Behaviour Change, Dietary Behavior, Metabolic Health
- Trial name
- BRE-13 (NCT07869355)
- Testing
- Explore the effect of MedDiet vs. Usual Diet on Fatty Acid Profile, Explore the effect of MedDiet vs. Usual Diet on Breast Tumor Tissue, Explore the effect of MedDiet vs. Usual Diet on Lipids
- Volunteers
- 30 people
- Sponsor
- University of Illinois at Chicago
Autosomal Dominant Polycystic Kidney, Overweight and Obesity
Daily Caloric Restriction in ADPKD
This clinical trial will determine whether a daily-caloric restriction-based weight loss intervention can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese.
- Trial name
- NCT04907799
- Testing
- Daily caloric restriction, Standard advice control
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Colorado, Denver
Vitamin D Deficiency, Obesity
Vitamin D Deficiency and Low Bone Mineral Content in Children
The Vitamin D study is designed to investigate the effect of body fat mass on vitamin D levels in children. Earlier studies have shown that individuals with increased fat mass may have low vitamin D levels.
- Trial name
- VDS (NCT00756899)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Morbid Obesity Requiring Bariatric Surgery
SAPI vs SASI in the Management of Morbid Obesity
Study Design A single-center cohort study combining prospective and retrospective data collection was conducted. The prospective arm enrolled consecutively admitted patients, while the retrospective arm analyzed previously…
- Trial name
- NCT07618598
- Testing
- Single Anastomosis Sleeve Ileal (SASI) Bypass Procedure, Single Anastomosis Plication Ileal (SAPI) Bypass Procedure
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University
High Cholesterol
Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults
High cholesterol concentration is a major risk factor for cardiovascular disease (CVD), and consumption of fish has been associated with a lower CVD risk in several studies.
- Trial name
- NCT06364163
- Testing
- Herring oil concentrate, Control
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Childhood Obesity, Cardiovascular Disease
The Effects of California Strawberries on Parameters of Cardiovascular Health
The prevalence of childhood obesity has been increasing over the past couple of decades. Similar to adults, overweight and obesity in young children and adolescents is associated with an increased number of cardiovascular risk…
- Trial name
- NCT01705093
- Testing
- flavonoid-rich freeze-dried strawberry powder, macronutrient-matched control powder
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Knee Osteoarthritis
Efficacy of Non-animal Chondroitin Sulphate for Overweight Subjects With Knee Ostoarthritis.
Knee osteoarthritis (OA) is predicted to become the fourth leading cause of disability worldwide by 2020. and is estimated to affect more than 40 million people in Europe and 4 million people in Italy.
- Trial name
- NACSKO (NCT03731793)
- Testing
- Non-Animal Chondroitin Sulphate
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Obesity, Abdominal, Cancer Prevention
Central Obesity and Cancer Prevention for Chinese American Women
This project examines the feasibility of a smartphone-based intervention to reduce obesity and breast cancer risk among Chinese American women in San Francisco.
- Trial name
- NCT03805516
- Testing
- SCOPP-CW, Control
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- San Francisco State University
Obesity
Changes in Sexual Function Following Bariatric Surgery
The main purposes of the study are to compare changes in sexual function, changes in sex hormones, and changes in body image and marital satisfaction at 12, 24, 36 and 48 months postoperatively in two groups: individuals who…
- Trial name
- NCT00670098
- Testing
- Bariatric surgery, lifestyle intervention (behavioral weight loss)
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes (DM), Hypertension
Multimodal Cardiovascular Magnetic Resonance Imaging for Cardiometabolic Pre-HF and HFpEF
This is an observational study aiming to characterize the pathophysiological features and clinical significance of cardiometabolic early-stage heart failure using advanced multimodal cardiovascular magnetic resonance (CMR)…
- Conditions
- Diabetes (DM), Hypertension, Heart Failure, Obesity & Overweight
- Trial name
- NCT07336316
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Obesity &Amp; Overweight
Effects of Grape Consumption on the Immune-Gut Axis in Obesity
This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.
- Trial name
- NCT07231484
- Testing
- Freeze-dried grape powder
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia