Clinical trials: Overload
Iron Overload, Hereditary Hemochromatosis
Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis
Brief Summary: This study was designed to explore a safe dose and characterize the preliminary safety and efficacy of ICL670 in adult patients with previously documented history of homozygous C282Y.
- Trial name
- NCT00395629
- Testing
- Deferasirox (ICL670)
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 49 people
- Sponsor
- Novartis Pharmaceuticals
Sickle Cell Disease, Iron Overload
Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients
This study will examine the long-term safety and efficacy of Deferasirox in patients with sickle cell disease and iron overload from repeated blood transfusions.
- Conditions
- Sickle Cell Disease, Iron Overload, Hemolytic Anemia
- Trial name
- NCT00110617
- Testing
- Deferasirox (ICL670), Deferoxamine (DFO)
- Where
- 59 sites in United States, Canada
- Volunteers
- 212 people
- Sponsor
- Novartis Pharmaceuticals
Anemia, Hemosiderosis
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia Patients
A 1-year randomized Phase II core trial was conducted to investigate the efficacy of deferasirox in regularly transfused patients with β-thalassemia and other rare chronic anemia 2 years of age and older.
- Trial name
- NCT00303329
- Testing
- Deferasirox
- Where
- 28 sites in United States, Belgium and 5 more
- Volunteers
- 184 people
- Sponsor
- Novartis Pharmaceuticals
Salmeterol Effect Against an Acute Alveolar Fluid Clearance Challenge Secondary to Lung Fluid Overload in COPD Patients, Chronic Obstructive Pulmonary Disease
Effect of Salmeterol on Fluid Clearance From Alveolar-Capillary Membrane in COPD Patients
The cardiovascular component associated with COPD plays a major role in prognosis of the disease, being responsible of 25% of the deaths.
- Conditions
- Salmeterol Effect Against an Acute Alveolar Fluid Clearance Challenge Secondary to Lung Fluid Overload in COPD Patients, Chronic Obstructive Pulmonary Disease, Bronchodilator Agents, Salmeterol
- Trial name
- SALM1 (NCT01271556)
- Testing
- Salmeterol, saline infusion (0.9 per cent sodium chloride)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Milan
Iron Overload
Assessment of Iron Deposition in Major Organs of Hemodialysis Patients
The purpose of the present study is to evaluate in hemodialysis patients, who have elevated serum ferritin ( >2000ng/ml) and transferrin saturation (TSAT) >30%, iron deposition in the heart, pancreas, liver and spleen using the…
- Trial name
- NCT01169961
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Wolfson Medical Center
Iron Overload
Fetal Parenchymatic Evaluation (Liver, Spleen) Using T2* Sequences
The purpose of this study is to prospectively evaluated the T2* values of normal feti.A standardized scale of T2* values for fetal and neonatal iron organ overload have yet to be reported or devised.
- Trial name
- NCT01121094
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Iron Overload
MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions.
Sickle cell anemia and Sickle cell β thalassemia patients require multiple transfusions in order to avoid chronic anemia sequel.
- Trial name
- NCT00629291
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Iron Overload, Thalassemia
Combination Iron Chelation Therapy
Patients with beta-thalassemia (Cooley's Anemia) continue to suffer from the transfusion-induced iron overload due to the inadequacies of current iron-chelation therapy.
- Trial name
- NCT00004982
- Testing
- Combination Iron Chelation Therapy
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Beta-thalassemia Major, Iron Overload
Therapeutic Effects of Silymarin in Patients With B-thalassemia Major
Silymarin, a flavonolignan complex isolated from Silybum marianum, has a strong antioxidant, hepatoprotective and iron chelating activities.
- Trial name
- NCT00999349
- Testing
- Silymarin (LEGALON)
- Where
- Iran
- Volunteers
- 140 people
- Sponsor
- Isfahan University of Medical Sciences
Iron Overload, Oxidative Stress
Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children
The purpose of study is to evaluate and compare the effect of iron supplementation when given as iron tablet or fortified biscuit or combined with zinc in the form of tablet on morbidity and iron toxicity markers among children…
- Trial name
- NCT00980421
- Testing
- Iron Supplementation
- Where
- India
- Volunteers
- 240 people
- Sponsor
- Annamalai University
Iron Overload
Safety and Efficacy of Ferriprox™ (Deferiprone) Oral Solution in Iron Overloaded Pediatric Patients
The primary objective is to assess the safety of Ferriprox oral solution for the treatment of iron overload in pediatric patients with transfusion-dependent anemia.
- Trial name
- NCT00529152
- Testing
- Deferiprone
- Where
- 4 sites in Egypt, Indonesia and 1 more
- Volunteers
- 100 people
- Sponsor
- ApoPharma
Hypertension, Fluid Overload
The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis
Peritoneal dialysis (PD) is a widely used modality of renal replacement therapy. Due to its continuous nature of therapy, better control of fluid status and preservation of residual renal function were presumed by most…
- Conditions
- Hypertension, Fluid Overload, Heart Diseases
- Trial name
- NCT00852514
- Testing
- Bioelectrical impedance-guide dry weight reduction
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Iron Overload, Cardiomyopathy
Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major
Myocardial iron overload is the leading cause of death in patients with beta-thalassemia major (TM). Therapy with deferoxamine (DFO) combined with deferiprone (DFP) reduces myocardial iron and improves cardiac function.
- Trial name
- DFODFPTM (NCT00800761)
- Testing
- Deferoxamine and Deferiprone, Deferoxamine
- Where
- Italy
- Sponsor
- Ospedale Microcitemico
Hemochromatosis, Iron Overload
Iron Overload in African Americans
Iron overload (hemochromatosis) is a condition which causes the intestines to take too much iron into the body from food or pills. The extra iron can build up in the liver, heart, joints, pancreas, sex organs, and other organs.
- Trial name
- NCT00001455
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Iron Overload, Iron Deficiency
Study of the Effects of Muscular Activity on Iron Metabolism
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be…
- Trial name
- NCT00378469
- Testing
- 45 minute exercise on ergocycle
- Where
- 2 sites in France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital